Investigation on stability of procaine hydrochloride injection
- Received Date: 2010-07-22
- Rev Recd Date: 2010-12-15
-
Key words:
- procaine hydrochloride injection /
- stability /
- P-Amino benzoic acid /
- HPLC
Abstract: Objective To investigate the effect of temperature and humidity on the stability of procaine hydrochloride injection. Methods Three batches of the test samples were stored in condition of 40±2 centigrade, relative humidity 75%±5% for 0 month,2 months, 4 months and 6 months respectively. Contents of procaine hydrochloride and its degradation product p-amino benzoic acid were determined in procaine hydrochloride injection by RP-HPLC. Results The content of procaine hydrochloride injection gradually decreased by 10% in 6 months, degradation products p-amino benzoic acid gradually increased by 412.89% in 6 months. Conclusion Procaine hydrochloride injection was instability in 40±2 centigrade and 75%±5% relative humidity condition.
Citation: | YOU Ben-ming, SONG Hong-jie. Investigation on stability of procaine hydrochloride injection[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(2): 125-127. |