Progress of oral sustained-release and controlled-release pellets

CHEN Ting; ZHANG Qian; SONG Hong-tao

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Objective To summarize the recent advances in oral sustained/controlled release pellets in international and domestic and prospect its developing future. Methods A great quantity of references were comprehensively reviewed. Results Various kinds of information of oral sustained/controlled release pellets including the characteristic,excipients,preparation methods and squash technique were summarized. Conclusions Pellets as multiple-unit drug delivery system have many advantages.With preparation techniques and excipient materials were gradually developed,pellets would play an important part in the development of sustained/controlled release drug delivery system.

Progress of oral sustained-release and controlled-release pellets

1. Department of Pharmacy,Fuzhou General Hospitol of PLA,Fuzhou 350025,China;Department of Pharmacy,School of clinical medicine of Fuzhou General Hospital,Fujian Medical University,Fuzhou 350025,China;School of Pharmacy,Fujian Medical University,Fuzhou 350004,China

2. School of Pharmacy,Fujian Medical University,Fuzhou 350004,China

3. Department of Pharmacy,Fuzhou General Hospitol of PLA,Fuzhou 350025,China;Department of Pharmacy,School of clinical medicine of Fuzhou General Hospital,Fujian Medical University,Fuzhou 350025,China

Received Date: 2010-09-15

Rev Recd Date: 2010-12-21

Key words:

pellets /
excipient /
coating /
squash technique

Abstract: Objective To summarize the recent advances in oral sustained/controlled release pellets in international and domestic and prospect its developing future. Methods A great quantity of references were comprehensively reviewed. Results Various kinds of information of oral sustained/controlled release pellets including the characteristic,excipients,preparation methods and squash technique were summarized. Conclusions Pellets as multiple-unit drug delivery system have many advantages.With preparation techniques and excipient materials were gradually developed,pellets would play an important part in the development of sustained/controlled release drug delivery system.

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Progress of oral sustained-release and controlled-release pellets

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