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NI Min, SHEN Fu-ming. Advances in the mechanism and medication cure ways of ischemia-reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 179-180,211.
Citation: NI Min, SHEN Fu-ming. Advances in the mechanism and medication cure ways of ischemia-reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 179-180,211.

Advances in the mechanism and medication cure ways of ischemia-reperfusion injury

  • Received Date: 2010-03-19
  • Rev Recd Date: 2011-02-28
  • Ischemia-reperfusion injury was a complex course in pathophysiology with many factors which had been implicated in the pathogenesis of a variety of clinical conditions including liver transplantation, and liver resectional surgery. The mechanism of ischemia-reperfusion injury and medication cure ways for ischemia-reperfusion injury were investigated in this paper.
  • [1] Banga NR,Homer-Vanniasinkam S,Graham A,et al.Ischemic preconditioning in transplantation and major resection of the liver[J].Br J Surg,2005,92(5):528. [2] Zeng Z,Huang HF,et al. Heme oxygenase-1 protects donor livers from ischemia/reperfusion injury:the role of Kupffer cells[J].World J Gastroenterol, 2010 Mar 14,16(10):1285. [3] Zhou W,Zhang Y,Hosch MS.Subcellular site of superoxide dismutase expression differentially controls AP-1 activity and injury in mouse liver following ischemia/reperfusion[J].Hepatology,2001,33(4):902. [4] Tsuchiya Y,Suzuki S,Inaba K,et al.Impact of endothelin-1 on microcirculatory disturbance after partial hepatectomy under ischemia/reperfusion in thioacetamide-induced cirrhotic rats[J].J Surg Res,2003,111(1):100. [5] Liu PG,He SQ,Wu Jian,et al.Protective effects of apocynin and allopurinol on ischemia/reperfusion induced liver injury in mice[J].World J Gastroenterol,2008, 14(18):2832. [6] Liu JN,Zhang JX,Zhang XL,et al.The effect of oxidative stress in myocardial cell injury in mice exposed to chronic intermittent hypoxia[J].Chin Med J(Engl),2010,123(1):74. [7] Wang NT, Lin HI. Effects of the antioxidants lycium barbarum and ascorbic acid on reperfusion liver injury in rats[J].Transplant Proc,2009,41(10):4110 [8] Glanemann M,Vollmar B,Nussler AK,et al.Ischemic preconditioning protects from hepatic ischemia/reperfusion injury by preservation of microcirculation and mitochondria redox-state[J].J Hepatol,2003,38(1):59. [9] Malhi H,Gores GJ,Lemasters JJ,et al.Apoptosis and necrosis in the liver:a tale of two deaths[J].Hepatology,2006,43(2 Suppl 1):831.[10] 张厚忠,韩喜春,姜伟栋.谷胱甘肽和缺血预处理对大鼠肝脏缺血再灌注损伤的影响[J].中国老年学杂志,2006,26(10):91.[11] 马兴久,耿振宏,李德春,等.乌司他汀对肝脏缺血-再灌注损伤的防护作用[J].医师进修杂志,2005,28(7):22.[12] 黄 博,陈高飞,陈国勇,等.茶多酚对大鼠肝脏缺血-灌注损伤的保护作用[J].胃肠病学和肝病学杂志,2006,15(5):522.[13] 林胜璋,余耀军,游 涛,等.大黄素对大鼠肝脏缺血再灌注损伤的预防作用[J].中国中西医结合外科杂志,2006,12(12):136.[14] 赵 珂.银杏叶提取物对大鼠肝脏缺血再灌注损伤的保护作用[J].中原医刊,2007,34 (3):5.[15] Ke QH,Zheng SS,Liang TB,et al.Pre-treatment of hypertonic saline can increase endogenous interleukin 10 release to attenuate hepatic ischemia reperfusion injury[J].Dig Dis Sc,2006,51:2257.[16] Gonzalez EA,Kozar RA,Suliburk JW,et al. Conventional dose hypertonic saline provides optimal gut protection and limits remote organ injury after gut ischemia reperfusion[J].J Trauma,2006,61(1):66.[17] Elahe T Crockett,James J Galligan,et al.Protection of early phase hepatic ischemia-reperfusion injury by cholinergic agonists[J].BMC Clinical Pathology,2006,15:6. [18] Wang DW,Zhou RB,Yao YM.Role of cholinergic anti-inflammatory pathway in regulating host response and its interventional strategy for inflammatory diseases[J].Chin J Traumatol,2009 Dec,12(6):355.[19] Liu C,Shen FM,Su DF,et al. Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor[J].Crit Care Med,2009,37(2):634.[20] Parrish WR,Rosas-Ballina M,Pavlov VA,et al.Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling[J].Mol Med,2008,14(9-10):567.[21] 孟兴凯,史留斌,彭淑牖,等.山莨菪碱抗肝脏缺血再灌注损伤的实验研究[J].中国急救医学,2001,21(1):4.[22] 黄 韧.山茛菪碱对大鼠供肝热缺血再灌注损伤的保护作用[J].临床和实验医学杂志,2009,8(1):17.
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Advances in the mechanism and medication cure ways of ischemia-reperfusion injury

Abstract: Ischemia-reperfusion injury was a complex course in pathophysiology with many factors which had been implicated in the pathogenesis of a variety of clinical conditions including liver transplantation, and liver resectional surgery. The mechanism of ischemia-reperfusion injury and medication cure ways for ischemia-reperfusion injury were investigated in this paper.

NI Min, SHEN Fu-ming. Advances in the mechanism and medication cure ways of ischemia-reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 179-180,211.
Citation: NI Min, SHEN Fu-ming. Advances in the mechanism and medication cure ways of ischemia-reperfusion injury[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 179-180,211.
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