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LI Hong-bin, YU Hong, YANG Shi-jie. Experimental study on anti-myocardial ischemia effect of Yixintong[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 188-192.
Citation: LI Hong-bin, YU Hong, YANG Shi-jie. Experimental study on anti-myocardial ischemia effect of Yixintong[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 188-192.

Experimental study on anti-myocardial ischemia effect of Yixintong

  • Received Date: 2010-01-20
  • Rev Recd Date: 2011-04-21
  • Objective To study the anti-myocardial ischemia effect of Yixintong. Methods The rat myocardial ischemia model was caused by isoprenaline and the experiment myocardial infraction dogs were used to observe the effect of Yixintong. Blood stasis model was used to observe the effect of Yixintong on blood viscosity and platelet aggregation. Results Yixintong (0.4 g/kg, 0.2 g/kg)could decrease ST length and rise serum enzyme(such as AST,CPK and LDH). Yixintong (0.4 g/kg,0.2 g/kg) could also lower the blood viscosity. Yixintong could improve hemorrheologic abnormality and lower the whole blood viscosity. Yixintong could inhibit platelet aggregation of rat. Yixintong could ameliorate the myocardial ischemia degree(Σ-ST) and decrease the myocardial ischemia coverage(N-ST). Yixintong could also decrease the rised serum enzyme(such as AST,CPK and LDH). Conclusions Yixintong had a protective and therapeutic action to the experimental myocardial ischemia.
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    [2] 张玉玺,姚晓颖,肖 艳,等.大根草提取物对模型大鼠心肌缺血的保护作用研究[J].中国药房,2009,20(33):2575.
    [3] 朴晋华,董培智,高天红,等.益心酮片对大鼠心肌缺血的保护作用[J]. 中国中药杂志,2003,28(5):442.
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    [5] 邱 全 ,王 辉 ,王海洋 ,等.水蛭颗粒对大鼠急性血瘀模型血液流变学、SOD、MDA的影响[J].实用中医药杂志,2008,24(11):687.
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Experimental study on anti-myocardial ischemia effect of Yixintong

Abstract: Objective To study the anti-myocardial ischemia effect of Yixintong. Methods The rat myocardial ischemia model was caused by isoprenaline and the experiment myocardial infraction dogs were used to observe the effect of Yixintong. Blood stasis model was used to observe the effect of Yixintong on blood viscosity and platelet aggregation. Results Yixintong (0.4 g/kg, 0.2 g/kg)could decrease ST length and rise serum enzyme(such as AST,CPK and LDH). Yixintong (0.4 g/kg,0.2 g/kg) could also lower the blood viscosity. Yixintong could improve hemorrheologic abnormality and lower the whole blood viscosity. Yixintong could inhibit platelet aggregation of rat. Yixintong could ameliorate the myocardial ischemia degree(Σ-ST) and decrease the myocardial ischemia coverage(N-ST). Yixintong could also decrease the rised serum enzyme(such as AST,CPK and LDH). Conclusions Yixintong had a protective and therapeutic action to the experimental myocardial ischemia.

LI Hong-bin, YU Hong, YANG Shi-jie. Experimental study on anti-myocardial ischemia effect of Yixintong[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 188-192.
Citation: LI Hong-bin, YU Hong, YANG Shi-jie. Experimental study on anti-myocardial ischemia effect of Yixintong[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(3): 188-192.
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