Studies on preparation and content determination of caffeine chewing gum (1. ;2. ) [Abstract] [Key words]
- Received Date: 2011-01-27
- Rev Recd Date: 2011-02-21
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Key words:
- caffeine chewing gum /
- determination /
- HPLC
Abstract: Objective To develop a new type of chewing gum contained caffeine, and a method for determination of caffeine in the chewing gum. Methods the caffeine powder and sugar powder were mixed evenly. the mixtures were reconciled with the chewing gum which were then cutted, extruded ,cooled and packaged. The caffeine in the gum was extracted by boiling water bath for 1h and caffeine content was determind by HPLC. Results This type of gum tastd good and the caffeine contained in the gum was uniform; The calibration curve showed good linearity in the range, and the mean of the extraction recovery rate was 98.41 ± 2.02%. Methodology of this study met the requirements of determination. Conclusion The technology of caffeine gum was simple and available; the developed HPLC method was easy, rapid , accurate and the quality was under control.
Citation: | FAN Yong-zheng, ZHANG Chen, CHEN Zhen-xing, LIU Jun-jie, LU Ying, ZHONG Yan-qiang, ZOU Hao. Studies on preparation and content determination of caffeine chewing gum (1. ;2. ) [Abstract] [Key words][J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 260-262,268. |