HE Xi-rui, LI Mao-xing, SHANG Xiao-fei, JIA Zheng-ping, ZHANG Ru-xue. Composition and anti-inflammatory activities of essential oils from Gentiana crassicaulis and Gentiana scabra[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 274-277,283.
Citation:
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HE Xi-rui, LI Mao-xing, SHANG Xiao-fei, JIA Zheng-ping, ZHANG Ru-xue. Composition and anti-inflammatory activities of essential oils from Gentiana crassicaulis and Gentiana scabra[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 274-277,283.
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Composition and anti-inflammatory activities of essential oils from Gentiana crassicaulis and Gentiana scabra
- 1.
Lanzhou General Hospital of PLA, Lanzhou 730050,China;Lanzhou University, Lanzhou 730000,China
- 2.
Lanzhou General Hospital of PLA, Lanzhou 730050,China
- Received Date: 2010-08-31
- Rev Recd Date:
2010-11-14
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Abstract
Objective To study the anti-inflammatory activities of essential oils from the roots of G. crassicaulis Duthie ex Burkand G. scabra Bunge in vivo and in vitro. Methods The essential oils were extracted by supercritical fluid extraction (SFE), and the chemical components of the essential oils were analyzed by GC-MS. In vitro and in vivo anti-inflammatory activities of the essential oils were investigated with a cellular model of LPS-stimulated RAW264.7 cell and xylene-induced ear edema in mice. Results The essential oils were transparent and full aroma, and 29, 40 compounds were identified from G. crassicaulis and G. scabra respectively. The essential oils of G. crassicaulis and G. scabra (GCEO and GSEO) showed a good performance of inhibiting NO production and xylene-induced ear edema in mice with a dose-dependent manner. Conclusion GCEO and GSEO had excellent anti-inflammatory activities in vivo and in vitro, and thus had great potential to be further studied on the active anti-inflammatory ingredients.
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References
[1]
|
中国科学院中国植物志编辑委员会. 中国植物志[M]. 北京:科学出版社, 1988: 62. |
[2]
|
杨永昌. 藏药志[M]. 西宁: 青海人民出版社. 1991: 9. |
[3]
|
刘占文, 陈长勋, 金若敏, 等. 龙胆苦苷的保肝作用研究[J]. 中草药, 2002, 33 (1): 47. |
[4]
|
陈长勋, 刘占文, 孙峥嵘, 等. 龙胆苦苷抗炎药理作用研究[J]. 中草药, 2003, 34(9): 814. |
[5]
|
陈 雷, 王海波, 孙晓丽, 等. 龙胆苦苷镇痛抗炎药理作用研究 [J]. 天然产物研究与开发, 2008, 20: 903. |
[6]
|
Tubaro A, Florio C, Luxich E, et al. Suitability of the MTT-based cytotoxicity assay to detect okadaic acid contamination of mussels[J]. Toxicon, 1996, 34: 965. |
[7]
|
Jeong GS, Lee DS, Kim YC. Cudratricusxanthone A from Cudrania tricuspidata suppresses pro-inflammatory mediators through expression of anti-inflammatory heme oxygenase-1 in RAW264.7 macrophages[J]. Int J Immunopharmacol, 2009, 9: 241. |
[8]
|
Kim JB, Han AR, Park EY, et al. Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-κB inactivation in RAW 264.7 macrophage cells[J]. Biol Pharm Bull, 2007, 30: 2345. |
[9]
|
Kou JP, Sun Y, Lin YY, et al. Anti-inflammatory activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents[J]. Biol Pharm Bull, 2005, 28: 1234. |
[10]
|
Girona J, Vallvé JC, Ribalta J, et al. 2,4-Decadienal downregulates TNF-α gene expression in THP-1 human macrophages[J]. Atherosclerosis, 2001, 158 : 95. |
[11]
|
肖寄平, 张炜煜. 脂肪酸在地龙抗炎作用研究中的指示作用[J/OL], 长春中医药大学, 中医中药网. |
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Proportional views
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