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Volume 29 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(5): 328-330,335

WANG Yuan-yuan, WANG Xin, WANG Yi-shan. Progress on diterpenoids gnidimacrin in Stellera chamaejasma L.[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 328-330,335.
Citation: WANG Yuan-yuan, WANG Xin, WANG Yi-shan. Progress on diterpenoids gnidimacrin in Stellera chamaejasma L.[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 328-330,335.
shu

Progress on diterpenoids gnidimacrin in Stellera chamaejasma L.

  • The Center for Tumor Treatment, 107th Hospital of PLA, Yantai 264002, China

  • Received Date: 2010-11-05
  • Rev Recd Date: 2011-04-29
  • A relatively complete summary on the anti-tumor component gnidimacrin was introduced, which was extracted from Stellera chamaejasma L. The research status of gnidimacrin's antitumor mechanism and its clinical application were reviewed. A further analysis on the feasibility and attenuated efficiency programs of the Gnidimacrin as an antitumor drug was made. The review could provide reference to exert the enormous potential of Chinese traditional medicine as much as possible and to deeply excavate the effective monomers.
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    [2] 冯威健,池川哲郎,吉田光二. 瑞香狼毒提取物尼地吗啉的抗癌活性[J].中华肿瘤杂志,1995,17(1):24.
    [3] Ikegawa T,Ikegawa A. Extraction of antitumor diterpenes from Stellera chamaejasma L.[P].日本专利, 08310993,1996-04-26.
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    [5] Kupchan SM,Shizuri Y,Murae T,et al. Letter:Gnidimacrin and Gnidima-crin 20-Palmitate,Novel Macrocycl-ic Antileukemic Diterpenoid Esters from Gnidia subcordata 1,2[J].Journal of the American Chemical Society,1976,98(18):5719.
    [6] 王润田,张坤娟,佟 慧,等. 瑞香狼毒甲醇提取物抗瘤机理研究[J].中华微生物和免疫学杂志,2003,23(9):734.
    [7] Feng WJ. Studies on antitumor active compounds of Stellera chamaejasma L. and their mechanism of action[J]. Toho Igokkai Zashi,1992,38(6):896.
    [8] Tatematsu H,Kurokawa M,Niwa M,et al. Piscidal constituents of Stellera chamaejasma L[J]. Chem Pharm Bull,1984,32(4):1612.
    [9] Yoshida M,Yokokura H,Hidaka H,et al. Mechanism of antitumor action of PKC activator,gnidimacrin[J]. Int J Cancer,1998,77(2):243.
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    [11] 贾正平,樊俊杰,谢景文,等.瑞香狼毒小鼠药物血清增敏化疗药物对K562/VCR耐药细胞的抗癌活性[J].西北国防医学杂志,2001,22(4):307.
    [12] 马 健,李永华,罗京滨,等. 瑞香狼毒协同化疗药物诱导耐药肝癌细胞凋亡作用研究[J].中医药学报,2007,35(6):15.
    [13] 樊俊杰, 贾正平, 谢景文,等. 瑞香狼毒和狼毒素对体外培养小鼠白血病P388细胞生长的影响[J]. 中药材,1996 ,19(11) :567.
    [14] 樊俊杰, 贾正平, 谢景文,等. 瑞香狼毒对小鼠移植肿瘤生长的影响[J] . 兰州医学院学报, 1994 ,20(4) :228.
    [15] 樊俊杰. 瑞香狼毒抗肿瘤作用及机制研究概况[J].医学临床研究,2007,24 (11) :2001.
    [16] 樊俊杰. 瑞香狼毒抗肿瘤作用及机制研究进展[J].实用预防医学,2007,14 (5) :1635.
    [17] 卓兆莲, 高 英, 李卫民. 蒙药瑞香狼毒的生物活性及毒副作用研究[J].中国现代中药,2007,9(12):32.
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    [20] 邬 俊,常 亮,琳 静.蒙药瑞香狼毒急性毒性试验研究[J].中国民族医药杂志,2010,1(1):41.
    [21] 潘国凤,杨 庆,刘 安,等. 瑞香狼毒药效组分抑制小鼠皮下移植瘤H22的实验研究[J].中华中医药杂志,2009,24 (4) :438.
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Progress on diterpenoids gnidimacrin in Stellera chamaejasma L.

  • The Center for Tumor Treatment, 107th Hospital of PLA, Yantai 264002, China
  • Received Date: 2010-11-05
  • Rev Recd Date: 2011-04-29

Abstract: A relatively complete summary on the anti-tumor component gnidimacrin was introduced, which was extracted from Stellera chamaejasma L. The research status of gnidimacrin's antitumor mechanism and its clinical application were reviewed. A further analysis on the feasibility and attenuated efficiency programs of the Gnidimacrin as an antitumor drug was made. The review could provide reference to exert the enormous potential of Chinese traditional medicine as much as possible and to deeply excavate the effective monomers.

WANG Yuan-yuan, WANG Xin, WANG Yi-shan. Progress on diterpenoids gnidimacrin in Stellera chamaejasma L.[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 328-330,335.
Citation: WANG Yuan-yuan, WANG Xin, WANG Yi-shan. Progress on diterpenoids gnidimacrin in Stellera chamaejasma L.[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(5): 328-330,335.
shu

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