Analysis of crystal differences of azithromycin precipitated in ethanol-water mixed solvents

JIANG De-hua; LIN Jing-ming; CHEN Jian-ming; WANG Xiao-yan; LI Yuan-yuan; ZHOU Chang-jiang

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Objective To study the crystal differences of azithromycin precipitated in ethanol-water mixed solvents. Methods By differential thermal analysis (DTA), X-ray powder diffraction and C-NMR analysis, the polymorphism of azithromycin were discussed by change the conditions of precipitation to precipitate crystal in ethanol-water mixed solvents. Results 4 kinds of azithromycin isample which had different DTA and XRD characteristics were acquired. Conclusions The DTA and X-ray diffraction characters of azithromycin were obtained, and conditions such as temperature and pressure could expand the research thinking of crystallization.

Analysis of crystal differences of azithromycin precipitated in ethanol-water mixed solvents

1. Graduates Management Brigade, Second Military Medical University, Shanghai 200433, China

2. School of Pharmacy , Second Military Medical University, Shanghai 200433, China

Received Date: 2011-03-01

Rev Recd Date: 2011-05-24

Key words:

azithromycin /
polymorphism /
DTA /
XRD

Abstract: Objective To study the crystal differences of azithromycin precipitated in ethanol-water mixed solvents. Methods By differential thermal analysis (DTA), X-ray powder diffraction and C-NMR analysis, the polymorphism of azithromycin were discussed by change the conditions of precipitation to precipitate crystal in ethanol-water mixed solvents. Results 4 kinds of azithromycin isample which had different DTA and XRD characteristics were acquired. Conclusions The DTA and X-ray diffraction characters of azithromycin were obtained, and conditions such as temperature and pressure could expand the research thinking of crystallization.

HTML

Reference (7)

[1]	王英杰,李玉琴.阿奇霉素的一般药理研究[J].山东医药工业,2000,19(1):76.
[2]	Ghobad M, Hadi V, Mohammad BJ, et al. Development of azithromycin-PLGA nanoparticles: Physicochemical characterization and antibacterial effect against Salmonella typhi[J].Colloid Surface B,2010,80:34.
[3]	Gandhi R, Pillai O, Thilagavathi R, et al. Characterization of Azithromycin hydrates[J]. Eur J Pharm Sci, 2002,16:175.
[4]	Blanco M, Valdés D, Bayod MS, et al. Characterization and analysis of polymorphs by near-infrared spectrometry[J].Anal Chim Acta,2004,502:221.
[5]	Zhang Z, Zhu YH, Yang XL, et al. Preparation of azithromycin microcapsules by a layer-by-layer self-assembly approach and release behaviors of azithromycin[J]. Colloid Surface A,2010,362:135 .
[6]	辉瑞产品公司.阿奇霉素的晶型[P].中国专利. CN1780847A,2006-05-31.
[7]	韩国药品株式会社.阿奇霉素水合物与1,2-丙二醇的包合物,其制备方法及包含其的药物组合物[P].中国专利. CN1505629A,2004-06-16.

[1]	王英杰,李玉琴.阿奇霉素的一般药理研究[J].山东医药工业,2000,19(1):76.
[2]	Ghobad M, Hadi V, Mohammad BJ, et al. Development of azithromycin-PLGA nanoparticles: Physicochemical characterization and antibacterial effect against Salmonella typhi[J].Colloid Surface B,2010,80:34.
[3]	Gandhi R, Pillai O, Thilagavathi R, et al. Characterization of Azithromycin hydrates[J]. Eur J Pharm Sci, 2002,16:175.
[4]	Blanco M, Valdés D, Bayod MS, et al. Characterization and analysis of polymorphs by near-infrared spectrometry[J].Anal Chim Acta,2004,502:221.
[5]	Zhang Z, Zhu YH, Yang XL, et al. Preparation of azithromycin microcapsules by a layer-by-layer self-assembly approach and release behaviors of azithromycin[J]. Colloid Surface A,2010,362:135 .
[6]	辉瑞产品公司.阿奇霉素的晶型[P].中国专利. CN1780847A,2006-05-31.
[7]	韩国药品株式会社.阿奇霉素水合物与1,2-丙二醇的包合物,其制备方法及包含其的药物组合物[P].中国专利. CN1505629A,2004-06-16.

Message Board

Analysis of crystal differences of azithromycin precipitated in ethanol-water mixed solvents

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views