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Volume 29 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2011  >  29(6): 442-444

LIU Wei, YANG Xue-ping, WANG Zhong-shi, WANG Meng, ZHANG Qiang, HAO Li-yong. Studies on thermal stability of total alkaloids in rhynchophylline[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 442-444.
Citation: LIU Wei, YANG Xue-ping, WANG Zhong-shi, WANG Meng, ZHANG Qiang, HAO Li-yong. Studies on thermal stability of total alkaloids in rhynchophylline[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 442-444.
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Studies on thermal stability of total alkaloids in rhynchophylline

  • 1.

    No.88 Hospital of PLA, Taian 271000, China

  • 2.

    No.88 Hospital of PLA, Taian 271000, China;Taishan Medical College, Taian 271000, China

  • 3.

    Taishan Medical College, Taian 271000, China

  • Received Date: 2010-11-20
  • Rev Recd Date: 2011-06-28
  • Objective To investigate the effect of heating on total alkaloids in rhynchphylla. Methods HPLC was employed to determine rhynchophylline and isorhynchophylline in total alkaloids among various conditions. Results Comparing with rhynchophylline, isorhynchophylline was unstable to heating. Heated in 60 ℃ and 90 ℃ for 2 hours, isorhynchophylline content decreased more than 38% and 50%, respectively. But rhynchophylline solution was stable in 60 ℃ for 2 hours and 4 ℃ for 6 days. In addition, rhynchophylline and isorhynchophylline were more stable in salt formation. Conclusion Isorhynchophylline was unstable to heating, which was the reason for rhynchophylla to given later.in decoct herbal medicine.
  • [1] 吴仪洛. 本草从新[M]. 上海: 上海科技出版社, 1958: 135.
    [2] 王 盟, 刘 卫, 邱庆浩, 等. 正交实验法优选钩藤总碱提取工艺[J]. 医药导报,2009, 28(9): 1200.
    [3] 何 昱, 洪筱坤, 王智华. 钩藤及其有效成分的药理研究进展[J]. 上海中医药杂志, 2003, 37(11): 57.
    [4] 郭协壎,顾雨时.钩藤的降低血压作用(煎法及其降压有效量的测定)[J].上海中医药杂志, 1959, 1: 46.
    [5] 王 盟, 刘 卫. 钩藤总生物碱的研究进展[J]. 实用医药杂志, 2008, 25 (3): 361.
    [6] 王瑞俭, 孙广仁, 孙宝民. 钩藤碱提取工艺研究[J]. 吉林林学院学报, 1998, 14(2): 1090.
    [7] 杜 旭. 钩藤的研究(3): 钩藤的降压活性成分及提取过程中含量的变化[J]. 国外医学中医中药分册, 2000, 26(6): 370.
    [8] 黄卓谦, 刘建利, 王玉英, 等. 钩藤煎煮过程中化学成分变化的研究[J]. 西北大学学报, 2008, 38(10): 787.
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Studies on thermal stability of total alkaloids in rhynchophylline

  • 1. No.88 Hospital of PLA, Taian 271000, China
  • 2. No.88 Hospital of PLA, Taian 271000, China;Taishan Medical College, Taian 271000, China
  • 3. Taishan Medical College, Taian 271000, China
  • Received Date: 2010-11-20
  • Rev Recd Date: 2011-06-28

Abstract: Objective To investigate the effect of heating on total alkaloids in rhynchphylla. Methods HPLC was employed to determine rhynchophylline and isorhynchophylline in total alkaloids among various conditions. Results Comparing with rhynchophylline, isorhynchophylline was unstable to heating. Heated in 60 ℃ and 90 ℃ for 2 hours, isorhynchophylline content decreased more than 38% and 50%, respectively. But rhynchophylline solution was stable in 60 ℃ for 2 hours and 4 ℃ for 6 days. In addition, rhynchophylline and isorhynchophylline were more stable in salt formation. Conclusion Isorhynchophylline was unstable to heating, which was the reason for rhynchophylla to given later.in decoct herbal medicine.

LIU Wei, YANG Xue-ping, WANG Zhong-shi, WANG Meng, ZHANG Qiang, HAO Li-yong. Studies on thermal stability of total alkaloids in rhynchophylline[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 442-444.
Citation: LIU Wei, YANG Xue-ping, WANG Zhong-shi, WANG Meng, ZHANG Qiang, HAO Li-yong. Studies on thermal stability of total alkaloids in rhynchophylline[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(6): 442-444.
shu

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