绞股蓝总皂甙对Lewis肺癌荷瘤小鼠肿瘤生长及免疫功能的影响
Effects of gypenosides on neoplasm growth and immunity function of Lewis lung neoplasm grafted mice
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摘要: 目的 观察绞股蓝总皂甙(gypenosides,GPs)对Lewis肺癌荷瘤小鼠肿瘤生长、脾淋巴细胞数及NK活性的影响。方法 整体动物的抑瘤试验、脾淋巴细胞计数及NK活性测定。结果 GPs对荷瘤小鼠Lewis肺癌细胞具有明显的抑制作用,在剂量10、20、40mg/kg腹腔注射(ip)给药条件下,其抑瘤率分别为(30.7±1.2)%,(51.5±2.5)%和(50.3±1.5)%(P<001).同时,GPs ip给药后荷瘤小鼠脾淋巴细胞总数明显增加,外周血淋巴细胞NK活性明显升高,脾淋巴细胞NK活性也明显升高。结论 GPs的抗肿瘤作用与其对荷瘤小鼠免疫功能的增强作用密切相关。Abstract: OBJECTIVE To study the effects of Gypenosides (GPs) on neoplasm growth, total number of splenic cells and NK cell activity. METHODS Antitumor experiment in mice was made and the total number of splen cells and NK cell activity were determined. RESULTS GPs could significantly inhibit the growth of Lewis lung cancer in mice. The inhibiting rates of tumor were (30.7±1.2)%,(51.5±2.5)% and (50.3±1.5)% (P<0.01) after ip GPs 10,20 and 40mg/kg,respectively. The total number of splenic cells and the NK cell activity of both PBL and splenic cells were elevated. CONCLUSION The antitumor effect of GPs is related to the elevated immunological function of tumor grafted mice.
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Key words:
- gypenosides /
- antineoplastic agents /
- lewis lung neoplasms /
- immunity
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