摘要:
目的 通过对45例银屑病患者应用复方丹参液治疗前后红细胞4项指数及血中MDA、SOD、GSH-PX含量的研究,探讨复方丹参液对它们的影响及银屑病的发病机理。方法 测定银屑病患者用药前后血中红细胞的4项指数及MDA、SOD、GSH-PX的含量,并与健康组比较。结果 银屑病患者红细胞4项指数均有异常,以平均红细胞体积(MCV)和平均红细胞血红蛋白浓度(MCHC)改变最为显着(P<0.05);血浆MDA水平较高,红细胞SOD、GSH-PX活性下降,而应用复方丹参液治疗后,MCV和MCHC值均有所改善,接近健康组;MDA水平下降,SOD、GSH-PX活性升高。
Abstract:
OBJECTIVE To study the effects of Fufang Danshen injection on indexes of red cell and malonyldialdehyde (MDA) content,superoxide enzyme (SOD) and glutathione-peroxidase (GHS-PX) activities in patients with psoriasis.METHODS Fourty-five psoriasis patients were treated with Fufang danshen,injection,compared with fifty normal subjects.We measured their four indexes of red cell,MDA,SOD and GSH-PX of blood.RESULTS The four indexes of psoriasis are all abnormal,especially the levels of mean cell volume (MCV) and mean concentration of hemoglobin (MCHC) (P<0 05).After treated with Fufang Dansen MCV and MCHC of red cell changed obviously,restored to normal levels.The level of MDA in patients increased and the activities of SOD,GSH-PX were decreased.After using Fufang Danshen the level of MDA decreased and SOD,GSH-PX were increased and P<0 05.CONCLUSION The abnormal degree of red cell in four indexes,MDA,SOD and GSH-PX were correlated with the stage of this disease,which suggest that abnormality of indexes of red cell and lipid-peroxidation may play a certain role in the pathogenesis of psoriasis,and this may be used as important reference indexes to judge the severity of the disease and evaluate the therapeutic effect of Fufang Danshen.