治疗药物监测进展
Development of therapeutic drug monitoring
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摘要: 目的 阐述治疗药物监测的必要性和测定技术。方法 对所监测的药物、取样和分析方法进行综述。结果 说明了药物监测的范围和指标,样品需求的条件,重点比较了色谱技术和免疫分析法在TDM中的应用和各自的优越性。结论 确保TDM的顺利进行,必须具备临床知识和掌握分析技术。Abstract: OBJECTIVE To review the principles of therapeutic drug monitoring (TDM)and the role of analytical techniques in TDM.METHODS The content included ranges of monitored drugs,sampling requirements and analytical aspects.RESULTS This article explained the criteria for undertaking drug level monitoring and the requirements of sampling,compared techniques of chromatographic and immunoassay.CONCLUSION For reliable results of TDM,it is necessary to implement good quality control of the assay to ensure that it continues to work satisfactorily.
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Key words:
- therapeutic drug monitoring /
- chromalography /
- immunoassay
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