四氯化碳致大鼠肝纤维化模型血液流变学性质的研究
Study on hemorheological changes of carbon tetrachloride(CCl4)induced hepatic fibrosis in rat
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摘要: 目的 研究大鼠肝纤维化时血液流变学性质的变化特征。方法 以四氯化碳诱导大鼠肝纤维化模型,检测血液粘度、血浆粘度、红细胞压积、红细胞特性指数等血液流变学参数,分析其变化特征。结果 与正常组比较,模型组大鼠全血粘度、全血还原粘度、血浆粘度、红细胞压积、红细胞聚集指数及红细胞刚性指数明显增高。结论 大鼠肝纤维化时血液粘度增大,红细胞流变性能减弱,易引发微循环障碍,加重肝纤维化的发展。Abstract: OBJECTIVE To study the hemorheological paramenters in rat with hepatic fibrosis. METHODS Hepatic fibrosis in rat was induced by CCl4 treatment. Whole blood viscosity, plasma viscosity, Hematocrit(Hct) and dynamic parameters of red blood cell(RBC) were investigated. RESULTS As compared with the normal group, the hemorheological parameters such as whole blood viscosity, plasma viscosity, Hematocrit(Hct), RBC's aggregation and rigidity were increased obviously. CONCLUSION High blood vicosity and low RBC's deformation ability can lead to blood circulation obstacle, thus will aggravate hepatic fibrosis.
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Key words:
- hepatic fibosis /
- hemorheology /
- red blood cell /
- carbon tetrachloride
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