新型口服固体速释制剂—口腔崩解片的研究概况
A new solid dosage form:orally disintegrating tablets
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摘要: 新型口服固体速释制剂—口腔崩解片以其在口腔内迅速崩解、起效快、生物利用度高、服用方便等特点受到了越来越多的药学工作者的关注,而且在很大程度上解决了老人、儿童等其他吞咽困难的病人服药难的问题.本文主要介绍了口腔崩解片的速崩机理、几种制备工艺及辅料,质量控制方法关键在于崩解时限和溶出度的检查,最后介绍了国内外已经上市的口腔崩解片的若干品种.Abstract: A new oral solid dosage form of rapidly disintegrating tablets have attracted increasing attention by its novel characteristics, such as fast disintegration, rapid absorption, high bioavailability, convient taking and so on. The dosage form brings great benefits to children and elderly people, especially those who have difficulities in swallowing. This article mainly describes the fast disintegration mechanism of orally disintegrating tablets, some preparation methods and excipients. The key quality properties are disintegrating time and dissolution. Finally, the article introduces some products that have already come into market.
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