三种化疗方案治疗进展期胃癌的成本效果分析
Cost-effectiveness analysis of three chemotherapeutic schemes for advanced gastric cancer
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摘要: 目的: 总结探讨不同化疗方案治疗进展期胃癌的成本效果比。 方法: 收集上海长海医院普外科2003年6月至2004年6月间收治的96例进展期胃癌患者的治疗数据。根据用药方案的不同,分成3组:A组32例(多西他赛+顺铂+5-氟尿嘧啶+亚叶酸钙);B组30例(盐酸表柔比星+顺铂+5-氟尿嘧啶+亚叶酸钙);C组34例(奥沙利铂+5-氟尿嘧啶+亚叶酸钙),运用成本效果分析方法对三种化疗方案进行经济学评价。 结果: 在三种化疗药物治疗方案中,多西他赛组有效率为56.25%,1个疗程的治疗成本为9979元,成本效果比177.40(元/百分之一有效率);盐酸表柔比星组有效率为40.00%,1个疗程的治疗成本为4158元,成本效果比103.95(元/百分之一有效率);奥沙利铂组有效率为52.94%,1个疗程的治疗成本为4498元,成本效果比84.96(元/百分之一有效率)。增量成本效果分析表明,A组的(⊿C/⊿E)为358.22;C组的(⊿C/⊿E)为26.28。 结论: C方案是三种化疗方案治疗进展期胃癌的最合理方案。Abstract: Objective: To explore the cost-effectiveness of different chemothrapeutic schemes in the treatment of advanced gastric cancer. Methods: 96 cases of gastric cancer were divided into three groups receiving different medication.A group(32 cases)with Do-cetaxel+Fluorouracil(5-FU)+Calcium folinate(CF)+Cisplatin(DDP);B group(30 cases)with Epirubicin+DDP+5-FU+CF; C group(34 cases)with Oxaliplatin+5-FU+CF.Date was evaluated using clinic economics cost-effectiveness analysis. Results: A-mong three groups,the effective rate of A group was 56.25% and expenditure of one therapeutic course was 9979 yuans,1% increase of effective rate 177.40 yuans.The effective rate of A group was 40.00% and expenditure of one therapeutic course was 4158 yuans, increase of 1% effective rate was costed 103.95yuans.The effective rate of C group was 52.94% and expenditure of one therapeutic course was 4498 yuans,1% increase of effective rate costed 84.96 yuans. Conclusion: C schemes is the most rational one among three chemotherapeutic programs for advanced gastric cancer.
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Key words:
- pharmacoeconomics /
- cost-effectiveness analysis /
- gastric cancer /
- chemotherapy
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