复方鲨鱼软骨素对小鼠移植性肉瘤S180抑瘤作用的拆方研究
Comparison of antitumor effect of complex shark cartilage and its components in mice transplanted with sarcoma 180
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摘要: 目的: 比较复方鲨鱼软骨素及其组分的抗肿瘤作用,探讨复方鲨鱼软骨素组方的合理性。 方法: 采用动物移植性肿瘤S180实体瘤为实验模型,按复方鲨鱼软骨素配方比例进行拆方,观察复方鲨鱼软骨素及其组分中的中药复方和鲨鱼软骨素的抗肿瘤效果。 结果: 复方鲨鱼软骨素剂量为5．0、2．5、1．25 g/(kg·d)时对动物移植性S180实体瘤均有明显的抑制作用,抑瘤率达80．2%～65．6%。拆方后与上述复方所含剂量相等的中药复方和鲨鱼软骨素对S180实体瘤的抑瘤率均在30%以下。 结论: 复方鲨鱼软骨素组方,能产生显著协同抗肿瘤作用。Abstract: Objective: To compare the antitumor effect of complex shark cartilage with its components alone. Methods: Complex shark cartilage and its components,Chinese tranditional medicines and shark cartilage,were given ig in sarcoma S180-bearing mice,re-spectively. Results: Complex shark cartilage at dose 5.0,2.5,and 1.25g/(kg·d)had significant antitumor effects.The inhibition rates against the tumors were 80.2%～65.6%.The Chinese tranditional medicines(2.4,1.2,and 0.6g/kg)and the shark cartilage (2.6,1.3,and 0.65g/kg)at the doses which were equal to those in the complex shark cartilage had mild antitumor effects.The inhibi-tion rates against the tumor were below 30%. Conclusion: The components of complex shark cartilage have significant antitumor effect in S180-bearing mice.
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Key words:
- complex shark cartilage /
- shark cartilage /
- cyclophosphamide /
- sarcoma 180
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