胆宁片对实验性急慢性肝损伤的保护作用
The protective effects of Danning tablet on experimental liver injury in mice and rats
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摘要: 目的:研究胆宁片对实验性小鼠急性肝损伤预防作用,及对大鼠慢性肝损伤的预防和治疗作用。方法:分别用D-氨基半乳糖和四氯化碳复制小鼠急性肝损伤和大鼠慢性肝损伤模型,检测小鼠和大鼠血清谷草转氨酶(AST)和谷丙转氨酶(ALT)的改变,观察胆宁片对大鼠血清总蛋白、白蛋白、A/G的影响、同时观察肝脏病理学改变。结果:胆宁片可明显抑制D-氨基半乳糖和四氯化碳引起的ALT、AST升高(P<0.05或P<0.01);可显著升高四氯化碳引起的血清总蛋白和白蛋白含量降低(P<0.05或P<0.01);肝脏病理组织学检查显示胆宁片可减轻肝细胞脂肪变性程度和纤维化程度。结论:胆宁片对小鼠D-氨基半乳糖急性肝损伤有较好的保护作用,对四氯化碳所致大鼠慢性肝损伤有一定的预防及治疗作用。Abstract: Objective:To study the protective effects of Danning tablet on CCl4 and D-galactosamine induced liver injury in mice and rats.Methods:Mice and rats were induced acute and chronic liver injury by administrated with D-galactosamine and CCl4 respectively,and the activities of glutamic-oxal(o)acetic transaminase(AST) and glutamate-pyruvate transaminase(ALT) in plasma were detected,influence on contents of the serum total protein,albumin and A/G were observed, histopathologic examination was employed to observe the liver injury. Results:Danning tablet can significantly inhibited the activities of ALT and AST which were rised by CCl4 and D-galactosamine(P<0.05 or P<0.01),can significantly increased the contents of the total protein, albumin which were decreased by CCl4(P<0.05 or P<0.01),Histopathologic examination show degree of fatty degeneration and fibrosis of liver cell were improved by Danning tablet.Conclusion: Danning tablet are effective in liver injuries induced by CCl4 and D-galactosamine.
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