摘要:
目的: 探讨昂丹司琼、格拉司琼、托烷司琼对预防肝癌患者介入治疗后引起的恶心、呕吐的疗效。 方法: 将120例行介入治疗的患者(为原发性肝癌),随机分为4组,每组30例。A组(对照组),甲氧氯普胺40mg;B组,昂丹司琼8mg;C组,格拉司琼3mg;D组,托烷司琼5mg。在介入治疗术中未灌注化疗药物前,通过导管向动脉内注射止吐药物。观察并记录4组患者术后的恶心、呕吐等不良反应,采用补救药物的病例数,恶心的严重程度,病人对止吐药物的满意度。 结果: B、C、D组恶心、呕吐的发生率小于A组(P<0.05),再次接受止吐药物的病人的百分率小于A组,D组的止吐疗效明显高于另外3组,比较有显著性差异(P<0.05);其不良反应发生次数也明显少于另外3组。 结论: 3种5-HT3受体拮抗剂对介入化疗栓塞术患者是有效的止吐药物,在肝癌介入治疗时,托烷司琼防止呕吐是一个更好的选择。
关键词:
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昂丹司琼 /
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格拉司琼 /
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托烷司琼 /
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肝肿瘤 /
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介入治疗 /
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呕吐 /
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预防
Abstract:
Objective: To compare the prophylactic efficacy of ondansetron,granisetron,and tropisetron on vomiting caused by TACE. Methods: 120 patients(with primary hepatocellular carcinoma) were randomly divided into four groups to receive ondanstron,granisetron,tropisetron via liver artery injection (n=30) and combined with metoclopramide as controls (n=30).The antiemetic efficacies were compared among the four groups for 5 consecutive days after TACE. Results: The effective rate of tropisetron group was significantly higher than that of the control group (P<0.05). Conclusion: Tropisetron is an effective antiemetic drug in controlling vomiting caused by TACE and should be advocated in clinical practice.