桂利嗪与尼莫地平对离体血管的舒张作用
Different relaxation effect of cinnarizine and nimodipine on isolated arteries
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摘要: 目的: 比较桂利嗪与尼莫地平对于离体血管的舒张作用。 方法: 分离SD大鼠胸主动脉,在内皮完整及去内皮的血管环上分别加入桂利嗪及尼莫地平,以累积剂量法给药至最大舒张剂量,观察药物对两种离体血管的舒张作用。 结果: 尼莫地平与桂利嗪均能剂量依赖性舒张内皮完整及去内皮血管。尼莫地平对内皮完整血管的舒张作用强于去内皮血管的舒张作用。桂利嗪对去内皮血管的舒张作用与内皮完整血管的作用相似。 结论: 尼莫地平的扩血管作用部分为内皮依赖性的,部分为对平滑肌的直接扩张作用;桂利嗪的扩血管作用主要是通过对平滑肌的直接扩张作用实现的。Abstract: Objective:This study was designed to investigate the different relaxation effect of cinnarizine and nimodipine on isolated arteries.Methods:Arteries were isolated from sixteen male Sprague-Dawley rats weighing 220~250 g,carefully dissected from sur- rounding fat and connective tissues,and cut into 2~3 mm-long circular segments.These segments were initially contracted with pheny- lephrine(1μM).When the contraction reached a steady state,cumulative concentration-respense(CR)curves to cinnarizine or ni- modipine were obtained by adding increasing concentrations to the segments that functional endothelium was present or absent.Re- sults:Both cinnarizine and nimodipine produced concentration-dependent relaxation on the segments that functional endothelium was present or absent.Nimodipine produced stronger relaxation on endothelium complete segments than on the endothelium removal ones. Cinnarizine produced a same relaxation on endothelium-complete segments and endothelium-removed ones.Conclusion:Cinnarizine and nimodipine produced different relaxation effects on endothelium-complete segments and endothelium-removed ones.The differ- ence between cinnarizine and nimodipine was depended on the integrity of the vascular endothelium.
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Key words:
- nimodipine /
- cinnarizine /
- vascular endothelium /
- relaxation
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