肾移植患者MDR1C3435T基因多态性对他克莫司血药浓度/剂量比及疗效的影响
Effect of MDR1C3435T genetic polymorphism on concentration/dose and efficacy of tacrolimus in patients with kidney transplantation
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摘要: 目的研究肾移植术后患者MDR1C3435T基因多态性对他克莫司(FK506)血药浓度/剂量比(C/D)及急性排斥反应和不良反应的影响。方法采用聚合酶链反应(PCR)和限制性内切片段长度多态性(RFLP)的方法检测肾移植患者MDR1C3435T基因型,比较不同基因型患者之间FK506的C/D值以及急性排斥反应、不良反应的差异。结果MDR1C3435T各基因型组间FK506的C/D值及急性排斥反应、不良反应均无显著性差异。结论MDR1C3435T基因多态性与肾移植患者FK506的C/D值及急性排斥反应、不良反应间无显著相关性。Abstract: Objective To investigate the impact of MDR1C3435T genetic polymorphism on the concentration/dose(C/D) ratio,acute rejection and adverse effect of tacrolimus(FK506)in the renal patients after transplantation. Methods The MDR1C3435T genotype was determined by PCR-RFLP method.The differences of C/D ratio,acute rejection and adverse reaction were compared among all of the genotype groups treated with FK506. Results There was no significant difference in the C/D ratio,rejection and adverse reaction of FK506 among MDR1C3435T genotype groups. Conclusion There was no significant relation between the C/D ratio,acute rejection and adverse reaction of FK506 and MDR1C3435T genetic polymorphism in the transplant patients.
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Key words:
- renal transplantation,tacrolimus /
- MDR1 /
- genetic polymorphism /
- concentration/dose /
- efficacy /
- adverse reaction /
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