留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

细胞外激活纳米载药系统研究进展

王晓宇 高静 张玮 朱全刚 武鑫 高申

王晓宇, 高静, 张玮, 朱全刚, 武鑫, 高申. 细胞外激活纳米载药系统研究进展[J]. 药学实践与服务, 2012, 30(1): 4-7,57. doi: 10.3969/j.issn.1006-0111.2012.01.002
引用本文: 王晓宇, 高静, 张玮, 朱全刚, 武鑫, 高申. 细胞外激活纳米载药系统研究进展[J]. 药学实践与服务, 2012, 30(1): 4-7,57. doi: 10.3969/j.issn.1006-0111.2012.01.002
WANG Xiao-yu, GAO Jing, ZHANG Wei, ZHU Quan-gang, WU Xin, GAO Shen. Progress on extracellularly activated nanocarriers[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 4-7,57. doi: 10.3969/j.issn.1006-0111.2012.01.002
Citation: WANG Xiao-yu, GAO Jing, ZHANG Wei, ZHU Quan-gang, WU Xin, GAO Shen. Progress on extracellularly activated nanocarriers[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 4-7,57. doi: 10.3969/j.issn.1006-0111.2012.01.002

细胞外激活纳米载药系统研究进展

doi: 10.3969/j.issn.1006-0111.2012.01.002
基金项目: 国家自然科学基金(81172514,30873178).

Progress on extracellularly activated nanocarriers

  • 摘要: 隐蔽性和靶向性对于纳米载体能否高效、选择性的递送药物非常重要,然而,传统方法难以让纳米载体同时具备这两种性质。新型靶向技术的迅速发展有望克服这一难点。本文在回顾传统靶向技术,阐述其取得的成果和面临的瓶颈的同时,着重讨论了利用环境刺激来激活的新型纳米载体的研究进展。
  • [1] Maeda H,Wu J,Sawa T,et al.Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review[J]. J Control Release, 2000,65(1-2): 271.
    [2] Yang T, Choi MK,Cui FD,et al.Preparation and evaluation of paclitaxel-loaded PEGylated immunoliposome[J]. J Control Release, 2007,120(3): 169.
    [3] Wang Y, Drummond DC,SHao Y,et al.Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines[J]. Int J Pharm, 2007. 337(1-2): 63.
    [4] Dagar S, Drummond DC,Noble CO,et al.VIP grafted sterically stabilized liposomes for targeted imaging of breast cancer: in vivo studies[J]. J Control Release, 2003,91(1-2): 123.
    [5] Allen T M. and P.R. Cullis, Drug delivery systems: entering the mainstream. Science, 2004,303(5665): 1818.
    [6] Hobbs, S.K, et al.Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment[J]. Proc Natl Acad Sci U S A, 1998,95(8): 4607.
    [7] Heldin, C.H, et al.High interstitial fluid pressure-an obstacle in cancer therapy[J]. Nat Rev Cancer, 2004,4(10): 806.
    [8] Gabizon, A, et al.In vivo fate of folate-targeted polyethylene-glycol liposomes in tumor-bearing mice[J]. Clin Cancer Res, 2003,9(17): 6551.
    [9] Gryparis, E.C, et al.Anticancer activity of cisplatin-loaded PLGA-mPEG nanoparticles on LNCaP prostate cancer cells[J]. Eur J Pharm Biopharm, 2007. 67(1): 1.
    [10] Gabizon, A.A, H. Shmeeda, and S. Zalipsky, Pros and cons of the liposome platform in cancer drug targeting[J]. J Liposome Res, 2006,16(3): 175.
    [11] Gerweck, L.E. and K. Seetharaman, Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res, 1996,56(6): 1194.
    [12] Egeblad, M. and Z. Werb, New functions for the matrix metalloproteinases in cancer progression[J]. Nat Rev Cancer, 2002,2(3): 161.
    [13] van Sluis, R, et al.In vivo imaging of extracellular pH using 1H MRSI. Magn Reson Med, 1999,41(4): 743.
    [14] Stubbs, M, et al.Causes and consequences of tumour acidity and implications for treatment[J]. Mol Med Today, 2000,6(1):15.
    [15] Yamagata, M, et al.The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase[J]. Br J Cancer, 1998,77(11): 1726.
    [16] Mohajer, G., E.S. Lee, and Y.H. Bae, Enhanced intercellular retention activity of novel pH-sensitive polymeric micelles in wild and multidrug resistant MCF-7 cells[J]. Pharm Res, 2007,24(9): 1618.
    [17] Ko, J., et al.Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy[J]. J Control Release, 2007,123(2): 109.
    [18] Lee, E.S, et al.Tumor pH-responsive flower-like micelles of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine)[J]. J Control Release, 2007. 123(1): 19.
    [19] Lee, E.S, et al.Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance[J]. J Control Release, 2008,129(3): 228.
    [20] Sawant, R.M,et al."SMART"drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers[J]. Bioconjug Chem, 2006,17(4): 943.
    [21] Sethuraman, V.A. and Y.H. Bae, TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors[J]. J Control Release, 2007,118(2): 216.
    [22] Kessenbrock, K, V. Plaks, and Z. Werb, Matrix metalloproteinases: regulators of the tumor microenvironment[J]. Cell, 2010,141(1): 52.
    [23] Chau, Y., F.E. Tan, and R. Langer. Synthesis and characterization of dextran-peptide-methotrexate conjugates for tumor targeting via mediation by matrix metalloproteinase II and matrix metalloproteinase IX[J]. Bioconjug Chem, 2004,15(4): 931.
    [24] Chau, Y, et al.Antitumor efficacy of a novel polymer-peptide-drug conjugate in human tumor xenograft models[J]. Int J Cancer, 2006,118(6): 1519.
    [25] Hatakeyama, H, et al.Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipi[J]d. Gene Ther, 2007,14(1): 68.
    [26] Mok, H, et al.PEGylated and MMP-2 specifically dePEGylated quantum dots: comparative evaluation of cellular uptake[J]. Langmuir, 2009,25(3): 1645.
  • [1] 宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅.  帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(7): 1-7. doi: 10.12206/j.issn.2097-2024.202303023
    [2] 冯志惠, 邓仪卿, 叶冰, 安培, 张宏, 张海军.  雀梅藤石油醚提取物诱导三阴性乳腺癌细胞凋亡的实验研究 . 药学实践与服务, 2024, 42(6): 253-259. doi: 10.12206/j.issn.2097-2024.202311055
    [3] 修建平, 杨朝爱, 刘禧澳, 潘乾禹, 韦广旭, 王卫星.  全反式维甲酸对肝星状细胞活化及氧化应激的作用和机制探索 . 药学实践与服务, 2024, 42(7): 1-6. doi: 10.12206/j.issn.2097-2024.202312054
    [4] 姜涛, 徐卫凡, 蒋益萍, 夏天爽, 辛海量.  巴戟天丸组方对Aβ损伤成骨细胞的作用及基于网络药理学的机制研究 . 药学实践与服务, 2024, 42(7): 1-7. doi: 10.12206/j.issn.2097-2024.202305011
    [5] 杨媛媛, 安晓强, 许佳捷, 江键, 梁媛媛.  正极性驻极体联合5-氟尿嘧啶对瘢痕成纤维细胞生长抑制的协同作用 . 药学实践与服务, 2024, 42(6): 244-247. doi: 10.12206/j.issn.2097-2024.202310027
    [6] 马兹芬, 许维恒, 金煜翔, 薛磊.  食管癌的靶向治疗与免疫治疗研究进展 . 药学实践与服务, 2024, 42(6): 231-237. doi: 10.12206/j.issn.2097-2024.202306008
  • 加载中
计量
  • 文章访问数:  3072
  • HTML全文浏览量:  143
  • PDF下载量:  305
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-05-07
  • 修回日期:  2011-06-02

细胞外激活纳米载药系统研究进展

doi: 10.3969/j.issn.1006-0111.2012.01.002
    基金项目:  国家自然科学基金(81172514,30873178).

摘要: 隐蔽性和靶向性对于纳米载体能否高效、选择性的递送药物非常重要,然而,传统方法难以让纳米载体同时具备这两种性质。新型靶向技术的迅速发展有望克服这一难点。本文在回顾传统靶向技术,阐述其取得的成果和面临的瓶颈的同时,着重讨论了利用环境刺激来激活的新型纳米载体的研究进展。

English Abstract

王晓宇, 高静, 张玮, 朱全刚, 武鑫, 高申. 细胞外激活纳米载药系统研究进展[J]. 药学实践与服务, 2012, 30(1): 4-7,57. doi: 10.3969/j.issn.1006-0111.2012.01.002
引用本文: 王晓宇, 高静, 张玮, 朱全刚, 武鑫, 高申. 细胞外激活纳米载药系统研究进展[J]. 药学实践与服务, 2012, 30(1): 4-7,57. doi: 10.3969/j.issn.1006-0111.2012.01.002
WANG Xiao-yu, GAO Jing, ZHANG Wei, ZHU Quan-gang, WU Xin, GAO Shen. Progress on extracellularly activated nanocarriers[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 4-7,57. doi: 10.3969/j.issn.1006-0111.2012.01.002
Citation: WANG Xiao-yu, GAO Jing, ZHANG Wei, ZHU Quan-gang, WU Xin, GAO Shen. Progress on extracellularly activated nanocarriers[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 4-7,57. doi: 10.3969/j.issn.1006-0111.2012.01.002
参考文献 (26)

目录

    /

    返回文章
    返回