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脯氨酸衍生物类有机催化剂的研究进展

赵明珠 姜志辉 蔡瞻 张大志

赵明珠, 姜志辉, 蔡瞻, 张大志. 脯氨酸衍生物类有机催化剂的研究进展[J]. 药学实践与服务, 2012, 30(1): 19-24,41. doi: 10.3969/j.issn.1006-0111.2012.01.005
引用本文: 赵明珠, 姜志辉, 蔡瞻, 张大志. 脯氨酸衍生物类有机催化剂的研究进展[J]. 药学实践与服务, 2012, 30(1): 19-24,41. doi: 10.3969/j.issn.1006-0111.2012.01.005
ZHAO Ming-zhu, JIANG Zhi-hui, CAI Zhan, ZHANG Da-zhi. Progress on proline derivatives as organocatalysts[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 19-24,41. doi: 10.3969/j.issn.1006-0111.2012.01.005
Citation: ZHAO Ming-zhu, JIANG Zhi-hui, CAI Zhan, ZHANG Da-zhi. Progress on proline derivatives as organocatalysts[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 19-24,41. doi: 10.3969/j.issn.1006-0111.2012.01.005

脯氨酸衍生物类有机催化剂的研究进展

doi: 10.3969/j.issn.1006-0111.2012.01.005

Progress on proline derivatives as organocatalysts

  • 摘要: 近年来,有机小分子催化剂已成为不对称合成研究领域的热点.脯氨酸在诸多不对称反应中显示出的良好的催化选择性,由此对脯氨酸的结构进行修饰和改造也引起人们的兴趣,以期得到催化性能更优越的催化剂。本文将脯氨酸衍生物分为十类,以其类型为线索综述了其在不对称催化反应中的研究进展。
  • [1] Yan ZY, Niu YN, Wei HL, et al. Combining proline and 'click chemistry': a class of versatile organocatalysts for the highly diastereo-and enantioselective Michael addition in water[J]. Tetrahedron: Asymmetry, 2006, 17: 3288.
    [2] Zhang L, Xu H, Mi XL, et al. Chiral pyrrolidine-azole conjugates: Simple and efficient asymmetric organocatalysts for Michael addition to nitrostyrenes[J]. Chinese Sci Bull, 2010, 55: 1735.
    [3] Saito S, Nakadai M, Yamamoto H. Diamine-protonic acid catalysts for catalytic asymmetric aldol reaction[J]. Synlett, 2001, 8: 1245.
    [4] Nobuyuki M, Yusuke N, Naoko O, et al. Organocatalytic direct asymmetric aldol reactions in water[J]. J Am Chem Soc, 2006, 128: 734.
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    [14] Yang H, Mahapatra S, Cheong PHY, et al. Highly stereoselective and scalable anti-aldol reactions using N-(p-Dodecylphenylsulfonyl)-2-pyrrolidinecarboxamide: scope and rigins of stereoselectivities[J]. J Org Chem, 2010, 75:7279.
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    [18] Tsogoeva SB, Jagtap SB, Ardemasova ZA, et al. Ardemasovab 4-trans-Amino-proline based di-and tetrapeptides as organic catalysts for asymmetric C-C bond formation reactions[J]. Tetrahedron: Asymmetry, 2006, 17: 989.
    [19] Chen FB, Huang S, Zhang H, et al. Proline-based dipeptides with two amide units as organocatalyst for the asymmetric aldol reaction of cyclohexanone with aldehydes[J]. Tetrahedron, 2008, 64: 9585.
    [20] Wu FC, Da CS, Du ZX, et al. N-Primary-Amine-Terminal γ-Turn tetrapeptides as organocatalysts for highly enantioselective aldol reaction[J]. J Org Chem, 2009, 74: 4812.
    [21] Agarwal J, Peddinti RK. Asymmetric michael addition catalysed by sugar-based prolinamides in solvent-free conditions[J]. Tetrahedron Lett, 2011, 52: 117.
    [22] Dinér P, Amedjkouh M. Aminophosphonates as organocatalysts in the direct asymmetric aldol reaction: towards syn selectivity in the presence of Lewis bases[J]. Org Biomol Chem, 2006, 4: 2091.
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  • 收稿日期:  2011-01-20
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脯氨酸衍生物类有机催化剂的研究进展

doi: 10.3969/j.issn.1006-0111.2012.01.005

摘要: 近年来,有机小分子催化剂已成为不对称合成研究领域的热点.脯氨酸在诸多不对称反应中显示出的良好的催化选择性,由此对脯氨酸的结构进行修饰和改造也引起人们的兴趣,以期得到催化性能更优越的催化剂。本文将脯氨酸衍生物分为十类,以其类型为线索综述了其在不对称催化反应中的研究进展。

English Abstract

赵明珠, 姜志辉, 蔡瞻, 张大志. 脯氨酸衍生物类有机催化剂的研究进展[J]. 药学实践与服务, 2012, 30(1): 19-24,41. doi: 10.3969/j.issn.1006-0111.2012.01.005
引用本文: 赵明珠, 姜志辉, 蔡瞻, 张大志. 脯氨酸衍生物类有机催化剂的研究进展[J]. 药学实践与服务, 2012, 30(1): 19-24,41. doi: 10.3969/j.issn.1006-0111.2012.01.005
ZHAO Ming-zhu, JIANG Zhi-hui, CAI Zhan, ZHANG Da-zhi. Progress on proline derivatives as organocatalysts[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 19-24,41. doi: 10.3969/j.issn.1006-0111.2012.01.005
Citation: ZHAO Ming-zhu, JIANG Zhi-hui, CAI Zhan, ZHANG Da-zhi. Progress on proline derivatives as organocatalysts[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 19-24,41. doi: 10.3969/j.issn.1006-0111.2012.01.005
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