Clinical efficacy of Compound Chuanqiong capsules and irbesartan in patients with diabetic nephropathy
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摘要: 目的 观察复方川芎胶囊联合厄贝沙坦治疗糖尿病肾病的疗效。 方法 将323例糖尿病肾病患者随机分为两组,对照组162例给予厄贝沙坦,试验组在厄贝沙坦治疗基础上给予复方川芎胶囊。 结果 疗程结束后,试验组患者血清光抑素C、血肌酐水平、24 h尿蛋白量均下降,且组间比较差异有显著性。 结论 复方川芎胶囊联合厄贝沙坦应用可减少患者血清光抑素C、血肌酐水平,复方川芎胶囊联合厄贝沙坦疗效与单用厄贝沙坦相比,对糖尿病肾病患者有较好的肾脏保护作用。Abstract: Objective To investigate the effect of combination of Compound Chuanqiong capsules and irbesartan in patients with diabetic nephropathy. Methods 323 patients with diabetic nephropathy were randomly divided into 2 groups. Group I (Compound chuanqiong capsules plus Irbesartan group,n=161)and Group II (Irbesartan group,n=162). After 6 months follow-up,cystatin C,serum creatinine,24 h urine protein quantitate were respectively detected and compared before and after treatment. Results Compared to patients in the control group cystatin C,the patients'serum creatinine,24 h urine protein quantities decreased (P＜0.05). Conclusion The combination of Compound Chuanqiong capsules and irbesartan was more effective than irbesartan alone in the treatment of diabetic nephropathy.
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Key words:
- Compound Chuanqiong capsules /
- irbesartan /
- diabetic nephropathy
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[1] 陈灏珠.实用内科学:七册[M].12版.北京:人民卫生出版社,2005:10l5. [2] 唐 兰,朱西娥,梁已安,等.磷酸川穹嗪对糖尿病周围血管病变的疗效初探[J].中国糖尿病杂志,1997,5(6):323. [3] 张曼华.中药川芎嗪合并消栓灵治疗糖尿病性周围神经病变50例体会[J].山东医药,1995,35(9):32. [4] 朱开元.安博维提供全面有效的肾脏保护作用[J].国际心血管病杂志,2007, 4:305. [5] 李春君,张秋梅.厄贝沙坦对糖尿病高血压的降压疗效及肾脏保护作用[J].实用糖尿病学,2006,5:41. [6] 苏 毅.糖尿病肾病发病机制研究进展[J].中国实用医药,2009,5:231. [7] Tu X, Chen X, Xie Y, et al. Anti-inflammatory renoprotective effect of clopidogrel and irbesartan in chronic renal injury[J]. J Am Soc Nephrol. 2008,19(1):77. [8] 唐 霓.糖尿病血液流变性改变与微血管病变关系的研究进展[J].微循环学杂志,2007,3:60,. [9] Parving HH,Lehnert H,Brochner-Mortensen J,et al. The Effect of Irbesartan on the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes[J]. N Engl J Med,2001,345(12):870. [10] 张宏宇.中西医结合治疗早期糖尿病肾病31例I临床观察[J].实用诊断与治疗杂志,2004,18(4):296. [11] 杨广智.化瘀固肾散治疗糖尿病早期肾病94例临床观察[J].山西中医,2003,19(6):14. [12] 焦 鹏.益气活血化瘀法治疗早期糖尿病肾病40例[J].新中医,2004,33(1I): 34. [13] 周 江.川芎有效成分及其药理作用研究概况[J].浙江中医杂志,2007,10: 614. [14] 玄 阳.当归的药理作用研究进展分析[J].医学信息,2011,24(5):1938. -
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