硬脂酸镁在直接压片工艺中产生的软化效应

王涛

doi:10.3969/j.issn.1006-0111.2014.01.005

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硬脂酸镁在直接压片工艺中产生的软化效应

王涛

文章导航 > 药学实践与服务 > 2014 > 32(1): 19-22

王涛. 硬脂酸镁在直接压片工艺中产生的软化效应[J]. 药学实践与服务, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005

引用本文:

王涛. 硬脂酸镁在直接压片工艺中产生的软化效应[J]. 药学实践与服务, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005

WANG Tao. Decreasing tablet strength of magnesium stearate in direct compression technology[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005

Citation:

WANG Tao. Decreasing tablet strength of magnesium stearate in direct compression technology[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 19-22. doi: 10.3969/j.issn.1006-0111.2014.01.005

硬脂酸镁在直接压片工艺中产生的软化效应

doi: 10.3969/j.issn.1006-0111.2014.01.005

王涛

汤臣倍健股份有限公司, 广东珠海 519040

Decreasing tablet strength of magnesium stearate in direct compression technology

WANG Tao

BY-HEALTH CO., LTD, Zhuhai 519040, China

摘要: 脂酸镁又名十八酸镁,在粉末直接压片工艺中具有重要作用,但是硬脂酸镁的使用,往往会对片剂产生一定的软化效应。从直压辅料的分类、物料粒径大小、辅料与硬脂酸镁的混合时间以及硬脂酸镁使用浓度等方面,简要分析产生此种软化效应的原因以及影响其大小的因素,以期为实际生产中提高粉末直接压片工艺有所借鉴和帮助。
- 硬脂酸镁 /
- 润滑剂 /
- 直压辅料 /
- 黏冲现象
Abstract: Magnesium stearate as a lubricant plays an important role in the direct compression of tablet technology, but the use of magnesium stearate often causes negative effect on tablet strength. The reasons of decreasing tablet strength from the aspects of excipients classification, particle size, blending time and lubricant concentration were briefly analyzed, which was helpful for the promotion and improvement of the tablet manufacturing level.
- magnesium stearate /
- lubricant /
- directly compressible excipients /
- sticking

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硬脂酸镁在直接压片工艺中产生的软化效应

doi: 10.3969/j.issn.1006-0111.2014.01.005

王涛

汤臣倍健股份有限公司, 广东珠海 519040

收稿日期: 2013-06-28
修回日期: 2013-11-06

关键词:

硬脂酸镁 /

润滑剂 /

直压辅料 /

黏冲现象

摘要: 脂酸镁又名十八酸镁,在粉末直接压片工艺中具有重要作用,但是硬脂酸镁的使用,往往会对片剂产生一定的软化效应。从直压辅料的分类、物料粒径大小、辅料与硬脂酸镁的混合时间以及硬脂酸镁使用浓度等方面,简要分析产生此种软化效应的原因以及影响其大小的因素,以期为实际生产中提高粉末直接压片工艺有所借鉴和帮助。