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脂微球载药系统的研究进展

章秀丽 马月琴 李刚

章秀丽, 马月琴, 李刚. 脂微球载药系统的研究进展[J]. 药学实践与服务, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
引用本文: 章秀丽, 马月琴, 李刚. 脂微球载药系统的研究进展[J]. 药学实践与服务, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
ZHANG Xiuli, MA Yueqin, LI Gang. Research development of lipid microsphere delivery system[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
Citation: ZHANG Xiuli, MA Yueqin, LI Gang. Research development of lipid microsphere delivery system[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003

脂微球载药系统的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.003
基金项目: 江西省自然科学基金项目(20122BAB215038).

Research development of lipid microsphere delivery system

  • 摘要: 脂微球递药系统是药剂学研究的热点,从脂微球载药系统的形成机制、构建方法及关键影响因素等方面进行综述,介绍该领域研究的进展和一些新发现,以促进脂微球作为药物载体的开发和应用。
  • [1] Liu ZZ, Feng YY, Zhang LL, et al. Pharmacokinetics and tissue distribution of larotaxel in rats: comparison of larotaxel-loaded microsphere with larotaxel-solution[J]. Cancer Chemother Pharmacol, 2013, 71(5): 1131-1139.
    [2] McClements DJ. Advances in fabrication of emulsions with enhanced functionality using structural design principles[J]. Curr Opin Colloid Interf Sci, 2012, 17(5): 235-245.
    [3] Groves MJ. The redistribution of bulk aqueous phase phospholipids during thermal stressing of phospholipid-stabilized emulsions[J]. Pharm Pharmacol, 1993, 45(7): 592.
    [4] Morais JM, Burgess DJ. Long acting injections and implants: micro-and nano-emulsions (controlled release parenteral drug delivery systems)[M].London: Springer, 2012: 221-238.
    [5] Yue PF, Lu XY, Liao MX, et al. The effect of oil components and homogenization conditions on the physicochemical properties of zedoary turmeric oil submicron emulsions[J]. J Dispers Sci Technol, 2010, 31(11):1535-1540.
    [6] Patel R, Joshi J. An overview on nanoemulsion: a novel approach[J]. Int J Pharml Sci Res, 2012, 3(12): 4640-4650.
    [7] Bague S, Philips B, Rabinovich-Guilatt L, et al. Ophthalmic oil-in-water type emulsion with stable zeta potential[P].USA WO2006050838 A2, 2005-10-10.
    [8] Akkar A, Muller RH. Intravenous itraconazole emulsions produced by SolEmuls technology[J]. Eur J Pharm Biopharm, 2003, 56(1): 29-36.
    [9] Müller RH, Schmidt S, Buttle I, et al. SolEmuls®-novel technology for the formulation of i.v. emulsions with poorly soluble drugs[J]. Int J Pharm, 2004, 269(2): 293-302.
    [10] Yue PF, Li FQ, Liao MX, et al. Process optimization, characterization, and release study in vitro of an intravenous puerarin lipid micropheres loaded with the phospholipid complex[J]. J Dispers Sci Technol, 2011, 32(1): 1-10.
    [11] Yue PF, Zheng Q, Wu B, et al. Application of plackett-burman design and box-behnken design to achieve process optimization for geniposide submicron emulsion[J]. J Dispers Sci Technol, 2012, 33(2): 213-222.
    [12] Ma YQ, Li G, Xu JH, et al. Combination of submicroemulsion and phospholipid complex for novel delivery of ursodeoxycholic acid[J]. Pharm Dev Technol,2014,19(3):363-372.
    [13] Gulati Neha, Gupta Himanshu. Parenteral drug delivery: a review[J]. Recent Patent Drug Deliv Form, 2011, 5(2): 133-145.
    [14] Yamamura K, Nakao M, Yano K, et al. Stability of forskolin in lipid emulsions and oil/water partition coefficients[J]. Chem Pharm Bull,1991, 39(4):1032-1034.
    [15] Bhalerao AV, Singh SS. In situ gelling ophthalmic drug delivery system for glaucoma[J]. Int J Pharm Biosci, 2011, 2(2): 7-14.
    [16] Patel Y, Poddar A, Sawant K. Formulation and characterization of Cefuroxime Axetil nanoemulsion for improved bioavailability[J]. J Pharm Bioallied Sci, 2012, 4(1): S4-S5.
    [17] Ammar H, Salama H, Ghorab M, et al. Nanoemulsion as a potential ophthalmic drug delivery system for Dorzolamide hydrochloride[J]. AAPS Pharm Sci Tech, 2009, 10(3): 808-819.
    [18] Gan L, Wang J, Jiang M, et al.Recent advances in topical ophthalmic drug delivery with lipid-based nanocarriers[J]. Drug Discov Today, 2013, 18(5-6): 290-297.
    [19] Lu Y, Qi J, Wu W. Absorption, disposition and pharmacokinetics of nanoemulsions[J]. Curr Drug Metab,2012, 13(4): 418-428.
    [20] Sultana Y, Maurya DP, Iqbal Z,et al. Nanotechnology in ocular delivery: current and future directions[J]. Drugs Today, 2011, 47(6): 441-455.
    [21] Zhang N, Zhang Q, Chu T, et al. Formulation optimization of prostaglandin E1-loaded lipid emulsion: enhanced stability and reduced biodegradation[J]. Pharm Dev Tech, 2013, 18(4): 804-812.
    [22] GaoY, Xu PF, Chen LL, Li YP. Prostaglandin E1 encapsulated into lipid nanoparticles improves its anti-inflammatory effect with low side-effect[J]. Int J Pharm, 2010, 387(1-2): 263-271.
    [23] Ueki R, Tanimoto M, Tatara T, et al. Emulsion of flurbiprofen axetil reduces propofol injection pain due to a decrease in free propofol concentration[J]. J Anesth, 2007, 21 (3): 325-329.
    [24] Shen J, Gan L, Zhu C, et al. Novel NSAIDs ophthalmic formulation: flurbiprofen axetil emulsion with low irritancy and improved anti-inflammation effect[J]. Int J Pharm, 2011, 412(1-2):115-122.
  • [1] 王雪莲, 郑斯莉, 李志勇, 罗亨宇, 缪朝玉.  全身过表达人METRNL基因小鼠模型的构建与验证 . 药学实践与服务, 2024, 42(5): 198-202, 222. doi: 10.12206/j.issn.2097-2024.202311014
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  • 收稿日期:  2013-05-21
  • 修回日期:  2014-03-17

脂微球载药系统的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.003
    基金项目:  江西省自然科学基金项目(20122BAB215038).

摘要: 脂微球递药系统是药剂学研究的热点,从脂微球载药系统的形成机制、构建方法及关键影响因素等方面进行综述,介绍该领域研究的进展和一些新发现,以促进脂微球作为药物载体的开发和应用。

English Abstract

章秀丽, 马月琴, 李刚. 脂微球载药系统的研究进展[J]. 药学实践与服务, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
引用本文: 章秀丽, 马月琴, 李刚. 脂微球载药系统的研究进展[J]. 药学实践与服务, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
ZHANG Xiuli, MA Yueqin, LI Gang. Research development of lipid microsphere delivery system[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
Citation: ZHANG Xiuli, MA Yueqin, LI Gang. Research development of lipid microsphere delivery system[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
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