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双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用

高洪元,  吴建勇,  倪曙民

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文章导航 > 药学实践与服务  > 2015 >  33(1): 9-12,16
高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
引用本文: 高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
shu
GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
Citation: GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
shu

双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用

doi: 10.3969/j.issn.1006-0111.2015.01.003
  • 1.

    复旦大学附属华山医院静安分院 肿瘤科, 上海 200040

  • 2.

    复旦大学附属华山医院静安分院 临床药理科, 上海 200040

  • 3.

    宁波大学附属医院肿瘤科, 浙江 宁波 315020

Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors

  • 1.

    Huashan Hospital Affiliated to Fudan University Jing'an Branch, Department of Oncology, Shanghai 200041, China

  • 2.

    Huashan Hospital Affiliated to Fudan University Jing'an Branch, Department of Clinical Pharmacology, Shanghai 200041, China

  • 3.

    Department of Oncology, Affiliated Hospital of Ningbo University, Ningbo 315020, China

  • 摘要: 血脑屏障的存在严重阻碍了脑肿瘤化疗药物向脑内递送。纳米粒、脂质体、胶束等纳米载体可显著增加药物的穿过血脑屏障转运的能力,采用单一或双功能基制备的双级靶向纳米载体还可进一步增加药物的脑内递送及在脑肿瘤病变部位的浓集,从而显著提高脑肿瘤的诊断和治疗效果。笔者主要介绍双级靶向纳米载体的设计思路、靶向功能基的最新研究进展,为相关研究提供参考。
    Abstract: The delivery of therapeutical agents for brain tumors' treatment is enormously prevented by the presence of blood-brain barrier.Nano-carriers such as nano-particles,liposomes and micelles can significantly increase the transport of drugs across the blood-brain barrier.The dual-targeting nano-carriers modified by one or two functional groups can further increase the brain delivery of drugs as well as their accumulation in brain tumors,resulting in significant improvement in the diagnosis and therapy of brain tumors.This article mainly focused on the recent development of strategies and functional groups of dual-targeting nano-carriers,providing a reference for relevant investigations.
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  • 收稿日期:  2013-11-12
  • 修回日期:  2014-04-21

双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用

doi: 10.3969/j.issn.1006-0111.2015.01.003
  • 1. 复旦大学附属华山医院静安分院 肿瘤科, 上海 200040
  • 2. 复旦大学附属华山医院静安分院 临床药理科, 上海 200040
  • 3. 宁波大学附属医院肿瘤科, 浙江 宁波 315020
  • 收稿日期: 2013-11-12
  • 修回日期: 2014-04-21

摘要: 血脑屏障的存在严重阻碍了脑肿瘤化疗药物向脑内递送。纳米粒、脂质体、胶束等纳米载体可显著增加药物的穿过血脑屏障转运的能力,采用单一或双功能基制备的双级靶向纳米载体还可进一步增加药物的脑内递送及在脑肿瘤病变部位的浓集,从而显著提高脑肿瘤的诊断和治疗效果。笔者主要介绍双级靶向纳米载体的设计思路、靶向功能基的最新研究进展,为相关研究提供参考。

English Abstract

高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
引用本文: 高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
shu
GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
Citation: GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
shu

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