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喹诺酮类抗菌药不良反应的研究进展

刘倩,  张晶,  林立敏,  卢克鹏,  宋洪涛

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文章导航 > 药学实践与服务  > 2015 >  33(6): 505-507,543
刘倩, 张晶, 林立敏, 卢克鹏, 宋洪涛. 喹诺酮类抗菌药不良反应的研究进展[J]. 药学实践与服务, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
引用本文: 刘倩, 张晶, 林立敏, 卢克鹏, 宋洪涛. 喹诺酮类抗菌药不良反应的研究进展[J]. 药学实践与服务, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
shu
LIU Qian, ZHANG Jing, LIN Limin, LU Kepeng, SONG Hongtao. Research progress of adverse drug reaction of quinolone antimicrobial agents[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
Citation: LIU Qian, ZHANG Jing, LIN Limin, LU Kepeng, SONG Hongtao. Research progress of adverse drug reaction of quinolone antimicrobial agents[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
shu

喹诺酮类抗菌药不良反应的研究进展

doi: 10.3969/j.issn.1006-0111.2015.06.007
  • 1.

    南京军区福州总医院药学科, 福建 福州 350025;沈阳药科大学药学院, 辽宁 沈阳 110016

  • 2.

    南京军区福州总医院药学科, 福建 福州 350025

Research progress of adverse drug reaction of quinolone antimicrobial agents

  • 1.

    Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China;School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

  • 2.

    Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China

  • 摘要: 喹诺酮类药物自开发以来由于其抗菌谱广、活性强而受到临床欢迎。其常见的不良反应包括:胃肠道紊乱、神经系统反应、皮肤反应等,大多程度轻微且可自愈。但某些品种上市后因严重的毒副作用而撤出市场,应当引起临床高度重视。笔者通过查阅国内外有关文献,总结其不良反应、发生不良反应的高危因素及在特殊人群中的应用,以期为临床合理用药提供参考。
    Abstract: Quinolones are widely used due to the wide antimicrobial spectrum and strong activity. The common adverse reactions of quinolones include gastrointestinal disturbances, central nervous system reaction, skin reaction, etc. These adverse reactions are mild in severity and self-healing. Since some agents were withdrawn from the market due to severe adverse effects, we should pay more attention to quinolones. Both internal and abroad literatures were reviewed, the adverse effects, the high risk factors of the adverse effects and the application in special population were summarized to provide reference for rational clinical drug use.
  • [1] Tome AM,Filipe A. Quinolones:review of psychiatric and neurological adverse reactions[J]. Drug Saf,2011,34(6):465-484.
    [2] 张霞光,李天云. 喹诺酮类抗菌药在临床使用中的不良反应[J].国外医药(抗生素分册),2003,24:30-33.
    [3] Kim J,Ohtani H,Tsujimoto M. Quantitative comparison of the convulsive activity of ombinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents[J].Drug Metab Pharmacok,2009,24(2):167-174.
    [4] 陈翠环,潘宁开. 喹诺酮类药物诱发精神症状的回顾性分析[J].实用医技杂志,2008,15(10):1278-1279.
    [5] 操银针. 喹诺酮类药物引起神经系统不良反应358例分析[J].医药导报,2007,26(10):1246-1247.
    [6] Ray WA,Murray KT,Hall,et al. Azithromycin and the risk of cardiovascular death[J].N Engl J Med,2012,366:1881-1890.
    [7] Lapi F,Wilchesky M, Kezouh A,et al. Fluoroquinolones and the risk of serious arrhythmia: a population-based study[J].Clin Infect Dis,2012,55:1457-65.
    [8] Adefurin A,Sammons H,Jacqz-Aigrain E,et al. Ciprofloxacin safety in paediatrics: a systematic review[J].Arch Dis Child,2011,96:874-80.
    [9] Schaad UB. Will fluoroquinolones ever be recommended for common infections in children?[J].Pediatr Infect Dis J,2007,26:865-867.
    [10] Pichichero ME,Arguedas A, Dagan R,et al. Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failure[J].Clin Infect Dis, 2005,41:470-478.
    [11] Seeger JD,West WA,Fife D,et al. Achilles tendon rupture and its association with fluoroquinolone antibiotics and other potential risk factors in amanaged care population[J]. Pharmacoepidemiol Drug Safe,2006,15:784-792.
    [12] Wise BL,Peloquin C,Choi H,et al. Impact of age,obesity,and steroiduse on quinolone-associated tendon disorders[J].Am J Med,2012,125:23-28.
    [13] Mandell LA,Ball P,Tillotson G. Antimicrobial safety and toler ability:differences and dilemmas[J].Clin Infect Dis,2001,32(Suppl):72-79.
    [14] Paterson JM,Mamdani MM, Manno M,et al. Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study[J].CMAJ,2012,184:1565-1570.
    [15] Etminan M, Forooghian F,Brophy JM,et al. Oral fluoroquinolones and the risk of retinal detachment[J].JAMA, 201,307:1414-1419.
    [16] Albini TA,Karakousis PC,Abbey AM,et al. Association between oral fluoroquinolones and retinal detachment[J].Am J Ophthalmol, 2012,154:919-921.
    [17] Christ W, Lehnert T,Ulbrich B. Specific toxicologic aspects of the quinolones[J].Rev Infect Dis,1988,10:141-146.
    [18] Kato M,Onodera T. Morphological investigation of cavity formation in articular cartilage induced by ofloxacin in rats[J].Fundam Appl Toxicol,1988,11 (1):110-119.
    [19] Grady R. Safety profile of quinolone antibiotics in the pediatric population[J].Pediatr Infect Dis,2003,22 (12):1128-1132.
    [20] van der Linden PD, Sturkenboom MC, Herings RM,et al. Fluoroquinolones and risk of achilles tendon disorders:case-control study[J].BMJ,2002, 324(7349):1306-1307.
    [21] Shaughnessy MK,Amundson WH, Kuskowski MA,et al. Unnecessary antimicrobial use in patients with current or recent Clostridium difficile infection[J].Infect Control Hosp Epidemiol,2013,34:109-116.
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出版历程
  • 收稿日期:  2014-03-03
  • 修回日期:  2014-06-26

喹诺酮类抗菌药不良反应的研究进展

doi: 10.3969/j.issn.1006-0111.2015.06.007
  • 1. 南京军区福州总医院药学科, 福建 福州 350025;沈阳药科大学药学院, 辽宁 沈阳 110016
  • 2. 南京军区福州总医院药学科, 福建 福州 350025
  • 收稿日期: 2014-03-03
  • 修回日期: 2014-06-26

摘要: 喹诺酮类药物自开发以来由于其抗菌谱广、活性强而受到临床欢迎。其常见的不良反应包括:胃肠道紊乱、神经系统反应、皮肤反应等,大多程度轻微且可自愈。但某些品种上市后因严重的毒副作用而撤出市场,应当引起临床高度重视。笔者通过查阅国内外有关文献,总结其不良反应、发生不良反应的高危因素及在特殊人群中的应用,以期为临床合理用药提供参考。

English Abstract

刘倩, 张晶, 林立敏, 卢克鹏, 宋洪涛. 喹诺酮类抗菌药不良反应的研究进展[J]. 药学实践与服务, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
引用本文: 刘倩, 张晶, 林立敏, 卢克鹏, 宋洪涛. 喹诺酮类抗菌药不良反应的研究进展[J]. 药学实践与服务, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
shu
LIU Qian, ZHANG Jing, LIN Limin, LU Kepeng, SONG Hongtao. Research progress of adverse drug reaction of quinolone antimicrobial agents[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
Citation: LIU Qian, ZHANG Jing, LIN Limin, LU Kepeng, SONG Hongtao. Research progress of adverse drug reaction of quinolone antimicrobial agents[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
shu

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