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替吉奥治疗晚期乳腺癌的研究进展

郑婷,  钱其军

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文章导航 > 药学实践与服务  > 2015 >  33(6): 557-560
郑婷, 钱其军. 替吉奥治疗晚期乳腺癌的研究进展[J]. 药学实践与服务, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
引用本文: 郑婷, 钱其军. 替吉奥治疗晚期乳腺癌的研究进展[J]. 药学实践与服务, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
shu
ZHENG Ting, QIAN Qijun. Progress on S-1 in the treatment of advanced breast cancer[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
Citation: ZHENG Ting, QIAN Qijun. Progress on S-1 in the treatment of advanced breast cancer[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
shu

替吉奥治疗晚期乳腺癌的研究进展

doi: 10.3969/j.issn.1006-0111.2015.06.021
  • 1.

    福建医科大学第一临床医学院, 福建 福州 350108;第二军医大学附属东方肝胆外科医院生物治疗科、病毒基因治疗实验室, 上海 200438

  • 2.

    第二军医大学附属东方肝胆外科医院生物治疗科、病毒基因治疗实验室, 上海 200438

基金项目: 国家科技重大专项(No.2013ZX10002-010-007)

Progress on S-1 in the treatment of advanced breast cancer

  • 1.

    First Clinical Medical College, Fujian Medical University, Fuzhou 350108, China;Laboratory of Gene and Viral Therapy, Department of Biotherapy, Eastern Hepatobiliary Surgery Hospital Affiliated to Second Military Medical University, Shanghai 200438, China

  • 2.

    Laboratory of Gene and Viral Therapy, Department of Biotherapy, Eastern Hepatobiliary Surgery Hospital Affiliated to Second Military Medical University, Shanghai 200438, China

  • 摘要: 替吉奥(S-1)是第三代氟尿嘧啶衍生物的口服抗癌剂,毒副作用小、疗效确切、给药方便。在大量的临床试验及不断的临床应用中,其展示出对晚期乳腺癌(advanced breast cancer,ABC)治疗的良好效果,将来有望成为乳腺癌治疗的一线化疗药物。
    Abstract: S-1 is the third generation of fluorouracil derivative anti-cancer agent with small side effects, efficacy, and drug delivery is convenient.In a large number of clinical trials and continuous clinical application, it showed the good effect for the treatment of advanced breast cancer, which was expected to become the first-line chemotherapy drug for breast cancer treatment in the future.
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    [8] 马培奇.抗肿瘤新药替吉奥钾研究进展[J].中国医药导刊,2007,9(6):499-502.
    [9] Malet-Martino M,Martino R. Clinical studies of three oralprodrugs of 5-fluorouracil(capecitabine,UFT,S-1):a review[J].Oncologist,2002,7(4):288-323.
    [10] Ito Y,Osaki Y,Tokudome N,et al.Efficacy of S-1 in heavilypretreated patients with metastatic breast cancer:cross-resistance to capecitabine[J].Breast Cancer,2009,16(2):126.
    [11] Saeki T,Takashima S,Sano M,et al.Aphase Ⅱ study of S-1 in patients with metastatic breast cancer-a Japanese trial by the S-1 Cooperative Study Group, Breast Cancer Working Group[J].Breast Cancer,2004,11(2):194-202.
    [12] Shien T,Shimizu C,Akashi-Tanakal S,et al.Clinical efficacy of S-1 in pretreated metastatic breast cancer patients[J].Jpn J Clin Oncol,2008,38(3):172-175.
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    [14] Lee JL,Kang YK,Kang HJ,et al.A randomised multicentre phaseⅡ trial of capecitabine vs S-1 as first-line treatment in elderly patients with metastatic or recurrent unresectable gastric cancer[J].Br J Cancer,2008,99(4):584-590.
    [15] Yamamoto D,Iwase S,Yoshida H,et al.Efficacy of S-1 in patients with capecitabine-resistantbreast cancer-Japan Breast Cancer Research Network (JBCRN) 04-1 trial[J].Anticancer Res,2010,30(9): 3827-3831.
    [16] Mukai H, Takashima T, HozumiY,et al.Randomized study of taxane versus TS-1 in women with metastatic or recurrent breast cancer (SELECT BC) [J].Jpn J Clin Oncol, 2010,40(8):811-814.
    [17] Nohara T,Iwamoto M,Sumiyoshi K, et al.Examination of the clinical usefulness of TS-1 in locally recurrent breast cancer[J]. Oncol Let,2010,1(4): 669-672.
    [18] Yamamoto Y, Nishimura R, Tanigawa T,et al.Efficacy and safety of TS-1 monotherapy for advanced/metastatic breast cancer-an observational study by the Kumamoto Breast Cancer Cooperative Group(KBCCG)].GanTo Kagaku Ryoho. 2014,41(10):1221-1225.
    [19] Kobayashi Y, Kadoya T, Kanno E,et al.A resected case of complete response after treatment with S-1 for recurrent squamous cell carcinoma component of the breast[J].GanTo Kagaku Ryoho,2012,39(9):1403-1406.
    [20] Tazawa K, Tsuchiya Y, Shinbo M,et al.Effective chemotherapy with S-1 alone in a patient with lung metastases of breast cancer[J].GanTo Kagaku Ryoho, 2011,38(3):423-425.
    [21] Yoshida H, Yamamoto D, Kanematsu S,et al.A case of multi-drug resistant breast cancer with liver metastasis treated effectively by S-1 monotherapy[J].GanTo Kagaku Ryoho,2010,37(13):2901-2903.
    [22] Takeyama H, Kyoda S, Yamashita A,et al.A case of repeated bone metastases of breast carcinoma successfully treated by S-1 chemotherapy[J].GanTo Kagaku Ryoho,2011,38(11):1873-1875.
    [23] Mori T, Yoshimura G, Ito D,et al.Three cases effectively treated with S-1 therapy for liver metastasis of breast cancer in long term[J].GanTo Kagaku Ryoho,2011,38(9):1495-1498.
    [24] Kubo H, Kijima D, Tada K,et al.A case of anthracycline- and taxane-resistant recurrent advanced breast cancer successfully treated with S-1 monotherapy[J].GanTo Kagaku Ryoho,2010,37(7):1325-1327.
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  • 收稿日期:  2015-02-09
  • 修回日期:  2015-06-04

替吉奥治疗晚期乳腺癌的研究进展

doi: 10.3969/j.issn.1006-0111.2015.06.021
  • 1. 福建医科大学第一临床医学院, 福建 福州 350108;第二军医大学附属东方肝胆外科医院生物治疗科、病毒基因治疗实验室, 上海 200438
  • 2. 第二军医大学附属东方肝胆外科医院生物治疗科、病毒基因治疗实验室, 上海 200438
    • 基金项目:  国家科技重大专项(No.2013ZX10002-010-007)
  • 收稿日期: 2015-02-09
  • 修回日期: 2015-06-04

摘要: 替吉奥(S-1)是第三代氟尿嘧啶衍生物的口服抗癌剂,毒副作用小、疗效确切、给药方便。在大量的临床试验及不断的临床应用中,其展示出对晚期乳腺癌(advanced breast cancer,ABC)治疗的良好效果,将来有望成为乳腺癌治疗的一线化疗药物。

English Abstract

郑婷, 钱其军. 替吉奥治疗晚期乳腺癌的研究进展[J]. 药学实践与服务, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
引用本文: 郑婷, 钱其军. 替吉奥治疗晚期乳腺癌的研究进展[J]. 药学实践与服务, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
shu
ZHENG Ting, QIAN Qijun. Progress on S-1 in the treatment of advanced breast cancer[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
Citation: ZHENG Ting, QIAN Qijun. Progress on S-1 in the treatment of advanced breast cancer[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 557-560. doi: 10.3969/j.issn.1006-0111.2015.06.021
shu

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