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辐射防护相关信号通路研究现状

王静,  章越凡,  李铁军

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文章导航 > 药学实践与服务  > 2017 >  35(1): 8-11
王静, 章越凡, 李铁军. 辐射防护相关信号通路研究现状[J]. 药学实践与服务, 2017, 35(1): 8-11. doi: 10.3969/j.issn.1006-0111.2017.01.003
引用本文: 王静, 章越凡, 李铁军. 辐射防护相关信号通路研究现状[J]. 药学实践与服务, 2017, 35(1): 8-11. doi: 10.3969/j.issn.1006-0111.2017.01.003
shu
WANG Jing, ZHANG Yuefan, LI Tiejun. Signaling pathways involved in radioprotection[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 8-11. doi: 10.3969/j.issn.1006-0111.2017.01.003
Citation: WANG Jing, ZHANG Yuefan, LI Tiejun. Signaling pathways involved in radioprotection[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 8-11. doi: 10.3969/j.issn.1006-0111.2017.01.003
shu

辐射防护相关信号通路研究现状

doi: 10.3969/j.issn.1006-0111.2017.01.003
  • 1.

    安徽中医药大学药学院, 安徽 合肥 230012

  • 2.

    第二军医大学药学院药理教研室, 上海 200433

  • 3.

    安徽中医药大学药学院, 安徽 合肥 230012;第二军医大学药学院药理教研室, 上海 200433

基金项目: “重大新药创制”科技重大专项：军队特需药品发现技术平台（2011ZXJ09201-012）

Signaling pathways involved in radioprotection

  • 1.

    College of Pharmacology, Anhui University of Chinese Medicine, Hefei 230012, China

  • 2.

    Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 3.

    College of Pharmacology, Anhui University of Chinese Medicine, Hefei 230012, China;Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 人们在生活中接触到各种辐射，长期或者大剂量的辐射能够导致组织损伤，其机制通常与细胞凋亡、坏死、炎症等相关。目前关于辐射防护的研究越来越多，其中涉及多条通路，代表性的通路有：NFκB通路、MAPK通路、PI3K/Akt通路、p53通路以及STAT3通路。笔者综述了上述通路在辐射防护领域的作用与研究现状。
    Abstract: People do have some risks of exposing to the radiation during their daily life.Longtime or megadose ionizing radiation can induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc..Currently, more and more radio protective agents were developed and several signaling pathways were involved. NFκB, MAPK, PI3k/Akt, p53 and STAT3 signaling pathways were reviewed in this article.
  • [1] Kamran MZ,Ranjan A, Kaur N,et al.Radioprotective agents:strategies andtranslational advances[J]. Med Res Rev, 2016, 36(3):461-493.
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    [3] 王坤平, 徐勇, 李长燕.抗辐射药物研发进展[J]. 军事医学, 2015,39(6):464-467.
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    [15] Yacoub A,McKinstry R, Hinman D, et al. Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling[J]. Radiat Res, 2003, 159(4):439-452.
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  • 收稿日期:  2016-10-13
  • 修回日期:  2016-12-19

辐射防护相关信号通路研究现状

doi: 10.3969/j.issn.1006-0111.2017.01.003
  • 1. 安徽中医药大学药学院, 安徽 合肥 230012
  • 2. 第二军医大学药学院药理教研室, 上海 200433
  • 3. 安徽中医药大学药学院, 安徽 合肥 230012;第二军医大学药学院药理教研室, 上海 200433
    • 基金项目:  “重大新药创制”科技重大专项：军队特需药品发现技术平台（2011ZXJ09201-012）
  • 收稿日期: 2016-10-13
  • 修回日期: 2016-12-19

摘要: 人们在生活中接触到各种辐射，长期或者大剂量的辐射能够导致组织损伤，其机制通常与细胞凋亡、坏死、炎症等相关。目前关于辐射防护的研究越来越多，其中涉及多条通路，代表性的通路有：NFκB通路、MAPK通路、PI3K/Akt通路、p53通路以及STAT3通路。笔者综述了上述通路在辐射防护领域的作用与研究现状。

English Abstract

王静, 章越凡, 李铁军. 辐射防护相关信号通路研究现状[J]. 药学实践与服务, 2017, 35(1): 8-11. doi: 10.3969/j.issn.1006-0111.2017.01.003
引用本文: 王静, 章越凡, 李铁军. 辐射防护相关信号通路研究现状[J]. 药学实践与服务, 2017, 35(1): 8-11. doi: 10.3969/j.issn.1006-0111.2017.01.003
shu
WANG Jing, ZHANG Yuefan, LI Tiejun. Signaling pathways involved in radioprotection[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 8-11. doi: 10.3969/j.issn.1006-0111.2017.01.003
Citation: WANG Jing, ZHANG Yuefan, LI Tiejun. Signaling pathways involved in radioprotection[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 8-11. doi: 10.3969/j.issn.1006-0111.2017.01.003
shu

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