尼莫地平微粉化物双层渗透泵控释片的制备

柴丽青; 阎爱荣

doi:10.3969/j.issn.1006-0111.2017.01.008

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尼莫地平微粉化物双层渗透泵控释片的制备

柴丽青, 阎爱荣

文章导航 > 药学实践与服务 > 2017 > 35(1): 31-35

柴丽青, 阎爱荣. 尼莫地平微粉化物双层渗透泵控释片的制备[J]. 药学实践与服务, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008

引用本文:

柴丽青, 阎爱荣. 尼莫地平微粉化物双层渗透泵控释片的制备[J]. 药学实践与服务, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008

CHAI Liqing, YAN Airong. Preparation of micronized nimodipine push-pull osmotic pump tablets[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008

Citation:

CHAI Liqing, YAN Airong. Preparation of micronized nimodipine push-pull osmotic pump tablets[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008

尼莫地平微粉化物双层渗透泵控释片的制备

doi: 10.3969/j.issn.1006-0111.2017.01.008

山西省人民医院药学部, 山西太原 030012

Preparation of micronized nimodipine push-pull osmotic pump tablets

Shanxi Provincial People's Hospital, Taiyuan 030012, China

摘要: 目的制备尼莫地平微粉化物双层渗透泵控释片。方法以尼莫地平为模型药物，将微粉化增溶技术应用于控释双层渗透泵剂型中，设计并制备体外控释12 h的尼莫地平双层渗透泵片，采用相似因子法（f₂）对不同处方释药行为的相似性进行评价，并对处方进行优化。结果成功制备了尼莫地平微粉化物双层渗透泵控释片，零级释放特征明显，符合渗透泵的释药机制。结论将微粉化增溶技术与控释双层渗透泵技术相结合，显著提高了难溶性药物尼莫地平的体外释放，成功制备了控释制剂。
- 尼莫地平 /
- 微粉化 /
- 双层渗透泵片 /
- 释放度 /
- 相似因子法
Abstract: Objective To prepare micronized nimodipine push-pull osmotic pump (PPOP) controlled release tablets. Methods The nimodipine as a model drug, micronization technique was applied to the PPOP method. Designed and prepared the controlled release of the nimodipine tablet for 12 hours in vitro. The factor f₂ was used to evaluate the similarities of different dissolution profiles, and the optimal formulation was performed. Results The micronized nimodipine PPOP controlled release tablets were successfully prepared with excellent zero-order release characteristics. The PPOP tablet's release behavior was close to the zero-order release equation (r=0.998 4). Conclusions The controlled-release formulation was prepared successfully. Micronized technique combined with the PPOP method significantly increased the release of the nimodipine tablet, the poorly soluble drug, in vitro.
- nimodipine /
- micronization /
- push-pull osmotic pump tablets /
- release /
- factor f₂

[1]	Thombre AG,Appel LE,Chidlaw M,et al.Osmotic drug delivery using swellable-core technology[J].J Control Release,2004, 94(1):75-89.
[2]	Langley MS,Sorkin EM.Nimodipine:a view of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in cerebra vascular disease[J].Drugs,1989,37(5):669-699.
[3]	姜红,金少红.固体药物制剂的溶出度比较[J].中国药事,2000,14(5):326-328.
[4]	夏锦辉,刘昌孝.固体药物制剂的体外溶出度的统计学评价分析[J].中国药学杂志,2000,35(2):130-131.

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尼莫地平微粉化物双层渗透泵控释片的制备

doi: 10.3969/j.issn.1006-0111.2017.01.008

山西省人民医院药学部, 山西太原 030012

收稿日期: 2015-08-25
修回日期: 2016-05-03

关键词:

尼莫地平 /

微粉化 /

双层渗透泵片 /

释放度 /

相似因子法

摘要: 目的制备尼莫地平微粉化物双层渗透泵控释片。方法以尼莫地平为模型药物，将微粉化增溶技术应用于控释双层渗透泵剂型中，设计并制备体外控释12 h的尼莫地平双层渗透泵片，采用相似因子法（f₂）对不同处方释药行为的相似性进行评价，并对处方进行优化。结果成功制备了尼莫地平微粉化物双层渗透泵控释片，零级释放特征明显，符合渗透泵的释药机制。结论将微粉化增溶技术与控释双层渗透泵技术相结合，显著提高了难溶性药物尼莫地平的体外释放，成功制备了控释制剂。