Study on the micelle properties of montelukast sodium in aqueous solution
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摘要: 目的 研究具有表面活性的药物孟鲁司特钠的水溶液性质，为其开发成胶束及其相关制剂提供实验依据。 方法 用电导法测定孟鲁司特钠的临界胶束浓度（critical micelle concentration， CMC）并考察温度对CMC的影响；用紫外-可见光分光光度法测定不同浓度孟鲁司特钠水溶液的透光率，并考察加入不同浓度氯化钠对吸光度和透光率的影响；高速离心法考察孟鲁司特钠水溶液形成胶束后的稳定性。 结果 孟鲁司特钠在25℃、30℃、35℃的CMC分别为0.75、0.82、0.90 mmol/L；氯化钠对孟鲁司特钠水溶液吸光度和透光率的影响不仅与氯化钠的浓度有关，还与孟鲁司特钠溶液的自身浓度有关；当孟鲁司特钠水溶液浓度>7.5 mmol/L时可得到澄清溶液且高速离心无沉淀。 结论 孟鲁司特钠为具有表面活性作用的药物，其水溶液的胶束性质易受温度和电解质的影响，可利用此性质将其开发为胶束或混合胶束制剂。Abstract: Objective To study the physicochemical properties of aqueous solution of surface active drug montelukast sodium (MS), which could provide experimental basis for further development of micelle or mixed micelle preparations. Methods Critical micelle concentration (CMC) of MS at different temperatures were determined by conductivity measurements. The absorbance and transmittance of MS aqueous solution were measured by UV at different sodium chloride concentration levels. The micelle stability was evaluated via high speed centrifugal. Results The CMC of MS aqueous solution at 25℃, 30℃, 35℃ were 0.75, 0.82, 0.90 mmol/L. The absorbance and transmittance of MS aqueous solution were affected by the sodium chloride concentration and the concentration of MS itself. It was observed that a clear solution was obtained when MS concentration >7.5 mmol/L and no precipitation was noticed even after high speed centrifugal. Conclusion Montelukast sodium is a surface active drug. Its solubility is related to MS concentration. The solubility is also sensitive to the temperature and the electrolyte concentration. These unique physicochemical properties could be used to develop micelle or mixed micelle pharmaceutical preparations.
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Key words:
- montelukast sodium /
- surface active /
- CMC /
- absorbance /
- transmittance /
- stability
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