Observation on the clinical curative effect of edaravone combined with ginkgo diterpene lactone on acute cerebral infarction
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摘要: 目的 研究依达拉奉联合银杏二萜内酯葡胺注射液治疗急性脑梗死（ACI）的临床疗效，探讨治疗ACI更为有效的治疗方案。 方法 收集2014年1月至2015年1月于解放军463医院神经内科住院治疗的ACI患者100例，根据随机数字表法将患者分为观察组和对照组，每组各50例，观察组在常规治疗基础上加用依达拉奉和银杏二萜内酯葡胺注射液，对照组在常规治疗基础上加用银杏二萜内酯葡胺注射液。两组均连续治疗14 d，于治疗前、后采用神经功能评分比较，观察两组患者的临床疗效、不良反应和治疗满意度，并进行统计分析。 结果 治疗前两组的神经功能缺损（NIHSS）评分无显著差异（P>0.05）。治疗后观察组的NIHSS评分明显优于对照组（P<0.05）。观察组总有效率为90%，对照组为66%，差异有统计学意义（P<0.05）。两组发生的主要不良反应有皮疹、恶心、头晕，且不良反应发生率无明显差异（P>0.05）。观察组患者的治疗满意度为94%，对照组为84%，差异有统计学意义（P<0.05）。 结论 在ACI常规治疗基础上，加用依达拉奉和银杏二萜内酯葡胺注射液，能够显著改善ACI患者的神经功能，提高治疗满意度，值得在临床推广使用。Abstract: Objective To analyze the effect of edaravone combined with ginkgo diterpene lactone in treatment of acute cerebral infarction (ACI) and discuss the better clinical treatment to ACI. Methods 100 cases of ACI and who accepted treatments in our hospital were selected as the research objects in January 2014 to January 2015.50 patients as observation group were given the treatment of edaravone and ginkgo diterpene lactone at the same time,while other 50 patients as control group were merely given the treatment of ginkgo diterpene lactone.At the same time,both groups were given treatment of conventional therapy.The total neurological function,effective rate,adverse reactions,and the treatment satisfaction of both groups before and after the treatment were observed. Results There were no significant different of NIHSS score of two groups before treatment (P>0.05).After treatment,NIHSS score of the observation group was significantly lower than the control group (P<0.05).The total effective rate of observation group was 90%,which was significantly higher than the control group (66%,P<0.05).The main adverse reactions were rash,nausea,dizziness of two groups,and there were no significant different of adverse reactions rate of two groups through the treatment (P>0.05).The treatment of patients with satisfaction rate of observation group was 94%,which was significantly higher than control group (84%,P<0.05). Conclusion Edaravone combined with ginkgo diterpene lactone had a good effect on improving nerve function of ACI patients,which could improve the treatment of patients with satisfaction,high security,and could be recommended in clinical.
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