盐酸美金刚治疗缺血性脑卒中研究进展

杨世畅; 李雪梅; 王曙霞; 何荆贵

doi:10.3969/j.issn.1006-0111.2018.04.002

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盐酸美金刚治疗缺血性脑卒中研究进展

杨世畅, 李雪梅, 王曙霞, 何荆贵

文章导航 > 药学实践与服务 > 2018 > 36(4): 293-296

杨世畅, 李雪梅, 王曙霞, 何荆贵. 盐酸美金刚治疗缺血性脑卒中研究进展[J]. 药学实践与服务, 2018, 36(4): 293-296. doi: 10.3969/j.issn.1006-0111.2018.04.002

引用本文:

杨世畅, 李雪梅, 王曙霞, 何荆贵. 盐酸美金刚治疗缺血性脑卒中研究进展[J]. 药学实践与服务, 2018, 36(4): 293-296. doi: 10.3969/j.issn.1006-0111.2018.04.002

YANG Shichang, LI Xuemei, WANG Yuxia, HE Jinggui. Progress in the ischemic stroke treatment with memantine hydrochloride[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 293-296. doi: 10.3969/j.issn.1006-0111.2018.04.002

Citation:

YANG Shichang, LI Xuemei, WANG Yuxia, HE Jinggui. Progress in the ischemic stroke treatment with memantine hydrochloride[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 293-296. doi: 10.3969/j.issn.1006-0111.2018.04.002

盐酸美金刚治疗缺血性脑卒中研究进展

doi: 10.3969/j.issn.1006-0111.2018.04.002

解放军总医院, 北京 100853

基金项目: 解放军总医院扶持基金（2016FC-CXYY-1009）

Progress in the ischemic stroke treatment with memantine hydrochloride

The General Hospital of PLA, Beijing 100853, China

摘要: 缺血性脑卒中是临床高发病，也是造成老年人永久残疾的重要原因之一。目前存在的治疗方法窗口期较短，寻找一种有效治疗缺血性脑卒中的药物是近年来研究的重点。盐酸美金刚是N-甲基-D-天冬氨酸受体拮抗剂，可有效缓解阿尔兹海默病的病程，近年来相关研究显示，盐酸美金刚可能具有治疗缺血性脑卒中的作用，综述该方面的研究进展，为相关药物的开发和治疗提供参考。
- 缺血性脑卒中 /
- 盐酸美金刚 /
- N-甲基-D-天冬氨酸受体拮抗剂
Abstract: Ischemic stroke is one of the leading causes of permanent disability in the elderly with high prevalence rate. The therapy window of current treatment is relatively short. Finding an effective treatment for ischemic stroke is the key point of research work. Memantine hydrochloride is an N-methyl-D-aspartate receptor antagonist which could effectively alleviate the course of Alzheimer's disease. Recent studies have shown that memantine may play a role in the treatment of ischemic stroke. Related literatures were reviewed, hoping to provide new ideas for the protective mechanism of memantinein the treatment of ischemic stroke.
- ischemic stroke /
- memantine hydrochloride /
- N-methyl-D-aspartate receptor antagonist

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盐酸美金刚治疗缺血性脑卒中研究进展

doi: 10.3969/j.issn.1006-0111.2018.04.002

解放军总医院, 北京 100853

基金项目: 解放军总医院扶持基金（2016FC-CXYY-1009）

收稿日期: 2018-05-23
修回日期: 2018-06-25

关键词:

缺血性脑卒中 /

盐酸美金刚 /

N-甲基-D-天冬氨酸受体拮抗剂

摘要: 缺血性脑卒中是临床高发病，也是造成老年人永久残疾的重要原因之一。目前存在的治疗方法窗口期较短，寻找一种有效治疗缺血性脑卒中的药物是近年来研究的重点。盐酸美金刚是N-甲基-D-天冬氨酸受体拮抗剂，可有效缓解阿尔兹海默病的病程，近年来相关研究显示，盐酸美金刚可能具有治疗缺血性脑卒中的作用，综述该方面的研究进展，为相关药物的开发和治疗提供参考。