Studies on the therapeutical effect of Yangwei granules for experimental gastric ulcer
-
摘要: 目的 研究养胃颗粒对实验性鼠胃溃疡的治疗作用。 方法 分别采用水浸应激性大鼠胃溃疡、乙酸烧灼性大鼠胃溃疡、吲哚美辛致小鼠胃溃疡、利血平致小鼠胃溃疡等4种胃溃疡动物模型，考察养胃颗粒对胃溃疡的治疗作用；采用乙酸引起小鼠扭体反应动物模型，考察养胃颗粒的镇痛作用。 结果 养胃颗粒灌胃给药对4种模型动物的胃溃疡均具有较好的保护效果，可以减轻胃黏膜损伤程度，降低溃疡指数，抑制溃疡形成，减少溃疡发生率；对乙酸引起小鼠扭体反应模型动物具有较好的镇痛效果，可以减少乙酸引起小鼠扭体反应的扭体次数。 结论 养胃颗粒具有明显的治疗实验性胃溃疡的作用，可以用于胃及十二指肠等消化性溃疡的治疗。Abstract: Objective To study the therapeutic effects of Yangwei granules on experimental gastric ulcer. Methods Four animal models of experimental gastric ulcer included water immersion stress and acetic acid induced gastric ulcer in rats, indomethacin and reserpine induced gastric ulcer in mice were used to observe the therapeutical effects of Yangwei granules on experimental gastric ulcer. The animal model of acetic acid induced writhing reaction test in mice was used to observe the analgesia effect. Results Yangwei granules of gavage administration had good protection effect on four animal models of experimental gastric ulcer. It reduced the degree of gastric mucosa damage and the ulcer index, inhibited the ulcer formation and lowered the ulcer incidence. It also had significant analgesic effect with reduced numbers of writhing reaction in mice model induced by acetic acid. Conclusion Yangwei granules had noticeable therapeutic effects for experimental gastric ulcer. It can be used to treat gastric and duodenal peptic ulcers.
-
Key words:
- Yangwei granules /
- experimental gastric ulcer /
- therapeutic effect
-
[1] 都兴东.养胃颗粒对胃溃疡模型鼠的治疗作用研究[J].医药导报,2006,25(11):1125-1126. [2] 朱斌,蒋平,杨阳,等.养胃颗粒对大鼠的长期毒性试验[J].中国医院药学杂志,2014,34(3):181-186. [3] 蒋平,杨阳,孙阳,等.养胃颗粒灌胃给药对小鼠的急性毒性实验[J].时珍国医国药,2014,25(4):841-843. [4] 蒋平,赵娜娜,陈晓,等.养胃颗粒对大鼠脏器的安全性评价[J].中国临床药理学杂志,2014,30(7):626-628. [5] 陈伟良,伍振峰,邓中银,等.中医药在抗胃溃疡研究应用中的现状与进展[J].中国实验方剂学杂志,2013,19(8):362-367. [6] 王凌娟,张雯.胃溃疡及实验性胃溃疡模型[J].中国烧伤创疡杂志,2000,12(2):66-69 [7] 涂朝勇,田徽,王建,等.路边菊水煎液抗实验性胃溃疡的研究[J].时珍国医国药,2009,20(10):2595-2596. [8] 徐晶晶,黄萍,吴清和,等.胃疡宁丸抗实验性胃溃疡的药效及机制研究[J].中国中药杂志,2013,38(5):736-739. [9] 李剑婷,黎红,刘婕英,等.养胃护膜颗粒对实验性胃溃疡作用的研究[J].哈尔滨医药,2013,33(4):253-254. [10] 沈鸿,张英华,田甲丽,等.胃舒安胶囊对动物实验性胃溃疡的影响[J].中国实验方剂学杂志,2010,16(13):174-176. [11] 曹春然,周建平,王志斌.胃平片的主要药效学研究[J].中国实验方剂学杂志,2006,12(11):47-49. [12] 陈灏珠.内科学[M].4版.北京:人民卫生出版社,1996,349-360. [13] KIM JJ,KIM N,LEE BH,et al.Risk factors for development and recurrence of peptic ulcer disease[J].Taehan Sohwagi Hakhoe chi,2010,56(4):220-228. [14] 廖承谱.浅析胃溃疡动物模型及机理[J].大众科技,2017,19(10):76-78. [15] 方尔笠,许宏俐,薛德彬,等.益气化瘀煎剂抗大鼠胃溃疡作用及其机制的探讨[J].中国中西医结合消化杂志,2001,9(4):208-210. [16] 卢文丽,方肇勤,潘志强,等.6种胃溃疡小鼠模型的征候特征及比较[J].上海中医药杂志,2007,41(8):63-68. [17] 孙敬方.动物实验方法学[M].北京:人民卫生出版社,2002,473-493. [18] 卢文丽,方肇勤,侯俐,等.常见胃溃疡模型小鼠胃组织病理变化及差异[J].中华中医药学刊,2008,26(3):551-555. [19] 王英.冰乙酸性大鼠胃溃疡模型制作方法比较[J].实用诊断与治疗杂志,2007,21(7):505-506. [20] 通拉嘎,梅红,其木格,等.大鼠乙酸型胃溃疡模型的建立与评价[J].中国民族民间医药,2017,26(11):49-51,55. -
点击查看大图
计量
- 文章访问数: 2881
- HTML全文浏览量: 443
- PDF下载量: 315
- 被引次数: 0
下载:
