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盐酸美金刚改善缺血性脑卒中患者神经认知功能的回顾性研究

杨世畅,  何荆贵,  周素月,  李雪梅

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文章导航 > 药学实践与服务  > 2018 >  36(5): 457-460
杨世畅, 何荆贵, 周素月, 李雪梅. 盐酸美金刚改善缺血性脑卒中患者神经认知功能的回顾性研究[J]. 药学实践与服务, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
引用本文: 杨世畅, 何荆贵, 周素月, 李雪梅. 盐酸美金刚改善缺血性脑卒中患者神经认知功能的回顾性研究[J]. 药学实践与服务, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
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YANG Shichang, HE Jinggui, ZHOU Suyue, LI Xuemei. The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
Citation: YANG Shichang, HE Jinggui, ZHOU Suyue, LI Xuemei. The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
shu

盐酸美金刚改善缺血性脑卒中患者神经认知功能的回顾性研究

doi: 10.3969/j.issn.1006-0111.2018.05.017

  • 解放军总医院, 北京 100853

基金项目: 科技部重点课题（2017YFC1307700）；军队保健专项课题（17BJZ39）

The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke

  • The General Hospital of PLA, Beijing 100853, China

  • 摘要: 目的 探讨盐酸美金刚（简称"美金刚"）改善缺血性脑卒中患者神经认知功能的效果。 方法 对2016年6月至12月于解放军总医院干部诊疗科进行治疗的缺血性脑卒中患者进行回顾性研究，根据其是否规律服用美金刚，分为美金刚组和非美金刚组，对两组患者的年龄、性别、BMI、随访时间及神经认知功能评分进行统计，神经认知功能评分采用蒙特利尔认知评估量表（MoCA）。 结果 两组患者的年龄、BMI、随访时间均无明显差异。初诊时，美金刚组MoCA评分（19.19±3.23），非美金刚组评分（18.47±3.03），P=0.651；2周时，美金刚组（21.06±2.62），非美金刚组（19.19±2.87），P=0.038；4周时，美金刚组（23.50±2.00），非美金刚组（21.30±2.16），P=0.002；末次随访时，美金刚组（24.69±2.09），非美金刚组（23.22±2.08），P=0.031。 结论 美金刚可有效改善缺血性脑卒中患者的神经认知功能。
    Abstract: Objective To investigate the effect of memantine hydrochloride on improving neurocognitive function in patients with ischemic stroke. Methods Patients with hemorrhagic stroke who were treated in the officer consultation department of General Hospital of PLA from June to December 2016 were retrospectively studied. According to whether or not they were taking memantine, the patients were divided into the memantine group and the control group. The data including age, sex, BMI, follow-up time, the neurocognitive function score were collected. The neurocognitive function score was assessed by the Montreal Cognitive Assessment Scale (MoCA). Results There was no significant difference in age, BMI, and follow-up time between the two groups. The MoCA score was(19.19±3.23) in memantine group, (18.47±3.03) in control group, P=0.651;(21.06±2.62)in memantine group,(19.19±2.87) in control group,P=0.038 at 2 weeks;(23.50±2.00) in memantine group,(21.30±2.16) in control group,P=0.002 at 4 weeks;At the last follow-up, memantine group was(24.69±2.09), control group was (23.22±2.08), P=0.031. Conclusion Memantine could effectively improve neurocognitive function in patients with ischemic stroke.
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  • 收稿日期:  2018-05-23
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盐酸美金刚改善缺血性脑卒中患者神经认知功能的回顾性研究

doi: 10.3969/j.issn.1006-0111.2018.05.017
  • 解放军总医院, 北京 100853
    • 基金项目:  科技部重点课题（2017YFC1307700）；军队保健专项课题（17BJZ39）
  • 收稿日期: 2018-05-23
  • 修回日期: 2018-06-27

摘要: 目的 探讨盐酸美金刚（简称"美金刚"）改善缺血性脑卒中患者神经认知功能的效果。 方法 对2016年6月至12月于解放军总医院干部诊疗科进行治疗的缺血性脑卒中患者进行回顾性研究，根据其是否规律服用美金刚，分为美金刚组和非美金刚组，对两组患者的年龄、性别、BMI、随访时间及神经认知功能评分进行统计，神经认知功能评分采用蒙特利尔认知评估量表（MoCA）。 结果 两组患者的年龄、BMI、随访时间均无明显差异。初诊时，美金刚组MoCA评分（19.19±3.23），非美金刚组评分（18.47±3.03），P=0.651；2周时，美金刚组（21.06±2.62），非美金刚组（19.19±2.87），P=0.038；4周时，美金刚组（23.50±2.00），非美金刚组（21.30±2.16），P=0.002；末次随访时，美金刚组（24.69±2.09），非美金刚组（23.22±2.08），P=0.031。 结论 美金刚可有效改善缺血性脑卒中患者的神经认知功能。

English Abstract

杨世畅, 何荆贵, 周素月, 李雪梅. 盐酸美金刚改善缺血性脑卒中患者神经认知功能的回顾性研究[J]. 药学实践与服务, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
引用本文: 杨世畅, 何荆贵, 周素月, 李雪梅. 盐酸美金刚改善缺血性脑卒中患者神经认知功能的回顾性研究[J]. 药学实践与服务, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
shu
YANG Shichang, HE Jinggui, ZHOU Suyue, LI Xuemei. The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
Citation: YANG Shichang, HE Jinggui, ZHOU Suyue, LI Xuemei. The retrospective study of the improvement of memantine hydrochloride on neurocognitive function in patients with ischemic stroke[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(5): 457-460. doi: 10.3969/j.issn.1006-0111.2018.05.017
shu

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