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Th2相关炎症因子在湿疹发病中的作用机制

朱聪聪,  潘会君,  朱全刚

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文章导航 > 药学实践与服务  > 2019 >  37(1): 9-13
朱聪聪, 潘会君, 朱全刚. Th2相关炎症因子在湿疹发病中的作用机制[J]. 药学实践与服务, 2019, 37(1): 9-13. doi: 10.3969/j.issn.1006-0111.2019.01.003
引用本文: 朱聪聪, 潘会君, 朱全刚. Th2相关炎症因子在湿疹发病中的作用机制[J]. 药学实践与服务, 2019, 37(1): 9-13. doi: 10.3969/j.issn.1006-0111.2019.01.003
shu
ZHU Congcong, PAN Huijun, ZHU Quangang. Mechanism of Th2 related inflammatory factors in the pathogenesis of eczema[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 9-13. doi: 10.3969/j.issn.1006-0111.2019.01.003
Citation: ZHU Congcong, PAN Huijun, ZHU Quangang. Mechanism of Th2 related inflammatory factors in the pathogenesis of eczema[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 9-13. doi: 10.3969/j.issn.1006-0111.2019.01.003
shu

Th2相关炎症因子在湿疹发病中的作用机制

doi: 10.3969/j.issn.1006-0111.2019.01.003
  • 1.

    上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437;上海市皮肤病医院药剂科, 上海 200443

  • 2.

    上海市皮肤病医院药剂科, 上海 200443

基金项目: 上海市科委资助项目（17401901800）

Mechanism of Th2 related inflammatory factors in the pathogenesis of eczema

  • 1.

    Department of Pharmacy Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China

  • 2.

    Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China

  • 摘要: 湿疹是临床常见的炎症性皮肤病，具有剧烈瘙痒、反复发作等特点。其病因复杂，包括多种内、外因素相互作用。主要发病机制与Th2免疫应答失衡有关，相关的炎症因子更是发挥十分重要的作用。上皮衍生因子胸腺基质淋巴细胞生成素以及白介素-33（IL-33）能够引发Th2免疫失衡，促进IL-4、IL-5、IL-13等炎症因子分泌，后者进一步诱导嗜酸性粒细胞增多、IgE生成。综述Th2相关炎症因子在湿疹发病中的作用机制，对湿疹治疗具有重要意义。
    Abstract: Eczema is a common clinical inflammatory skin disease characterized by severe itching and recurrent attacks.Its etiology is complex, including a variety of internal and external factors.The main mechanism is related to the imbalance of Th2 immune response, and related inflammatory factors play an important role.Epithelial-derived factor like thymic stromal lymphopoietin and interleukin-33 could trigger Th2 immune imbalance and promote the secretion of type inflammatory factors such as interleukin-4, interleukin-5, and interleukin-13.These inflammatory factors will further induce eosinophilic granulocytosis and IgE formation.In this paper, the research progress of mechanism of type 2 related inflammatory factors in eczema were reviewed, which provided the great significance for treatment.
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  • 收稿日期:  2018-09-28
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Th2相关炎症因子在湿疹发病中的作用机制

doi: 10.3969/j.issn.1006-0111.2019.01.003
  • 1. 上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437;上海市皮肤病医院药剂科, 上海 200443
  • 2. 上海市皮肤病医院药剂科, 上海 200443
    • 基金项目:  上海市科委资助项目（17401901800）
  • 收稿日期: 2018-09-28
  • 修回日期: 2018-11-20

摘要: 湿疹是临床常见的炎症性皮肤病，具有剧烈瘙痒、反复发作等特点。其病因复杂，包括多种内、外因素相互作用。主要发病机制与Th2免疫应答失衡有关，相关的炎症因子更是发挥十分重要的作用。上皮衍生因子胸腺基质淋巴细胞生成素以及白介素-33（IL-33）能够引发Th2免疫失衡，促进IL-4、IL-5、IL-13等炎症因子分泌，后者进一步诱导嗜酸性粒细胞增多、IgE生成。综述Th2相关炎症因子在湿疹发病中的作用机制，对湿疹治疗具有重要意义。

English Abstract

朱聪聪, 潘会君, 朱全刚. Th2相关炎症因子在湿疹发病中的作用机制[J]. 药学实践与服务, 2019, 37(1): 9-13. doi: 10.3969/j.issn.1006-0111.2019.01.003
引用本文: 朱聪聪, 潘会君, 朱全刚. Th2相关炎症因子在湿疹发病中的作用机制[J]. 药学实践与服务, 2019, 37(1): 9-13. doi: 10.3969/j.issn.1006-0111.2019.01.003
shu
ZHU Congcong, PAN Huijun, ZHU Quangang. Mechanism of Th2 related inflammatory factors in the pathogenesis of eczema[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 9-13. doi: 10.3969/j.issn.1006-0111.2019.01.003
Citation: ZHU Congcong, PAN Huijun, ZHU Quangang. Mechanism of Th2 related inflammatory factors in the pathogenesis of eczema[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 9-13. doi: 10.3969/j.issn.1006-0111.2019.01.003
shu

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