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19F核磁共振定量法测定含氟漱口液中氟化钠的含量

华俊杰,  朱海菲,  李育

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文章导航 > 药学实践与服务  > 2019 >  37(6): 518-520
华俊杰, 朱海菲, 李育. 19F核磁共振定量法测定含氟漱口液中氟化钠的含量[J]. 药学实践与服务, 2019, 37(6): 518-520. doi: 10.3969/j.issn.1006-0111.2019.06.009
引用本文: 华俊杰, 朱海菲, 李育. 19F核磁共振定量法测定含氟漱口液中氟化钠的含量[J]. 药学实践与服务, 2019, 37(6): 518-520. doi: 10.3969/j.issn.1006-0111.2019.06.009
shu
HUA Junjie, ZHU Haifei, LI Yu. Determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 518-520. doi: 10.3969/j.issn.1006-0111.2019.06.009
Citation: HUA Junjie, ZHU Haifei, LI Yu. Determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 518-520. doi: 10.3969/j.issn.1006-0111.2019.06.009
shu

19F核磁共振定量法测定含氟漱口液中氟化钠的含量

doi: 10.3969/j.issn.1006-0111.2019.06.009

  • 海军军医大学药学院 上海 200433

Determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR

  • School of Pharmacy, Naval Medical University, Shanghai 200433, China

  • 摘要: 目的 建立19F核磁共振技术测定含氟漱口液中氟化钠含量的方法。 方法 采用19F核磁共振技术，以三氟乙酸作为内标物，使用300MHz核磁共振波谱仪，在25℃下采集样品的19F核磁共振谱，建立内标标准曲线，用于氟化钠定量分析。 结果 氟化钠在0.1~0.8 mg/ml范围内，线性关系良好，回归方程为A=1.1392C-0.0013，r=0.99995；低、中、高3个浓度的平均回收率分别为99.36%、99.31%、99.65%，RSD分别为0.51%、0.35%、0.54%，含氟漱口液中氟化钠的平均含量为99.30%。 结论 研究建立的19F核磁共振方法准确度、精密度较好，能够快速、准确地测定含氟漱口液中氟化钠的含量。
    Abstract: Objective To establish a method for the determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR technique. Methods The 19F-NMR technique was used to establish the relevant standard curve with trifluoroacetic acid as the internal standard.The 19F-NMR spectrum of the sample was collected at 25℃ using a 300 MHz NMR spectrometer. Results The linear relationship of sodium fluoride was good in the range of 0.1-0.8 mg/ml.The regression equation was A=1.1392C-0.0013,r=0.99995.The average recovery of low,medium and high concentration levels were 99.36%,99.31.% and 99.65%,respectively,and RSD was 0.51%,0.35% and 0.54% respectively.The average content of sodium fluoride in the fluoride mouthwash was 99.30%. Conclusion The method was accurate and precise which could be used to determine the sodium fluoride in fluoride-containing mouthwash.
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  • 收稿日期:  2019-04-12
  • 修回日期:  2019-07-20

19F核磁共振定量法测定含氟漱口液中氟化钠的含量

doi: 10.3969/j.issn.1006-0111.2019.06.009
  • 海军军医大学药学院 上海 200433
  • 收稿日期: 2019-04-12
  • 修回日期: 2019-07-20

摘要: 目的 建立19F核磁共振技术测定含氟漱口液中氟化钠含量的方法。 方法 采用19F核磁共振技术，以三氟乙酸作为内标物，使用300MHz核磁共振波谱仪，在25℃下采集样品的19F核磁共振谱，建立内标标准曲线，用于氟化钠定量分析。 结果 氟化钠在0.1~0.8 mg/ml范围内，线性关系良好，回归方程为A=1.1392C-0.0013，r=0.99995；低、中、高3个浓度的平均回收率分别为99.36%、99.31%、99.65%，RSD分别为0.51%、0.35%、0.54%，含氟漱口液中氟化钠的平均含量为99.30%。 结论 研究建立的19F核磁共振方法准确度、精密度较好，能够快速、准确地测定含氟漱口液中氟化钠的含量。

English Abstract

华俊杰, 朱海菲, 李育. 19F核磁共振定量法测定含氟漱口液中氟化钠的含量[J]. 药学实践与服务, 2019, 37(6): 518-520. doi: 10.3969/j.issn.1006-0111.2019.06.009
引用本文: 华俊杰, 朱海菲, 李育. 19F核磁共振定量法测定含氟漱口液中氟化钠的含量[J]. 药学实践与服务, 2019, 37(6): 518-520. doi: 10.3969/j.issn.1006-0111.2019.06.009
shu
HUA Junjie, ZHU Haifei, LI Yu. Determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 518-520. doi: 10.3969/j.issn.1006-0111.2019.06.009
Citation: HUA Junjie, ZHU Haifei, LI Yu. Determination of sodium fluoride in fluoride-containing mouthwash by 19F-NMR[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(6): 518-520. doi: 10.3969/j.issn.1006-0111.2019.06.009
shu

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