[1] |
SHANG X F, PAN H, WANG X Z, et al. <italic>Leonurus</italic> <italic>japonicus</italic> Houtt. : ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine[J]. J Ethnopharmacol,2014,152(1):14-32. doi: 10.1016/j.jep.2013.12.052 |
[2] |
Kuang P G, Zhou X F, Zhang F Y, et al. Motherwort and cerebral ischemia[J]. J Tradit Chin Med,1988,8:37-40. |
[3] |
LIU X H, XIN H, HOU A J, et al. Protective effects of leonurine in neonatal rat hypoxic cardiomyocytes and rat infarcted heart[J]. Clin Exp Pharmacol Physiol,2009,36(7):696-703. doi: 10.1111/j.1440-1681.2008.05135.x |
[4] |
LIU X H, CHEN P F, PAN L L, et al. 4-Guanidino-n-butyl syringate (Leonurine, SCM 198) protects H9c2 rat ventricular cells from hypoxia-induced apoptosis[J]. J Cardiovasc Pharmacol,2009,54(5):437-444. doi: 10.1097/FJC.0b013e3181bae160 |
[5] |
FISKUM G, ROSENTHAL R E, VERECZKI V, et al. Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress[J]. J Bioenerg Biomembr,2004,36(4):347-352. doi: 10.1023/B:JOBB.0000041766.71376.81 |
[6] |
LIU X H, PAN L L, CHEN P F, et al. Leonurine improves ischemia-induced myocardial injury through antioxidative activity[J]. Phytomedicine,2010,17(10):753-759. doi: 10.1016/j.phymed.2010.01.018 |
[7] |
LIU X H, PAN L L, DENG H Y, et al. Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4[J]. Free Radic Biol Med,2013,54:93-104. doi: 10.1016/j.freeradbiomed.2012.10.555 |
[8] |
田逸君, 郑怡文, 朱玉平, 等. 雷公藤内酯醇的遗传毒性评价[J]. 药学实践杂志, 2016, 34(3):215-218. doi: 10.3969/j.issn.1006-0111.2016.03.006 |
[9] |
田逸君, 朱玉平, 朱江波, 等. 草苔虫内酯的遗传毒性评价[J]. 癌变畸变突变. 2012, 24(4): 309-312. |
[10] |
国家食品药品监督管理总局. 药物生殖毒性研究技术指导原则[EB/OL]. 2007. https://wenku.baidu.com/view/a9f9c49af78a6529647d5391.html. |
[11] |
OECD. Test Guidance 414. Prenatal Developmental Toxicity Study. In: OECD Guidance for Testing of Chemicals[S]. Paris: Organization for Economic Cooperation & Development, 2001. |
[12] |
国家食品药品监督管理总局. 药物遗传毒性研究技术指导原则[EB/OL]. 2007. https://wenku.baidu.com/view/2e1f1b1985868762caaedd3383c4bb4cf7ecb7a6.html. |
[13] |
周海钧主译. ICH 药品注册的国际技术要求(安全性部分)[M]. 北京: 人民卫生出版社, 2001: 37-61. |
[14] |
OECD. Test Guidance 471. Bacterial Reverse Mutation Test. In: OECD Guidance For Testing of Chemicals.[S] Paris: Organization for Economic Cooperation & Development, 1997. |
[15] |
OECD. Test Guidance 474. Mammalian Erythrocyte Micronucleus Test. In: OECD Guidance for Testing of Chemicals[S]. Paris: Organization for Economic Cooperation & Development, 1997. |
[16] |
OECD. Test Guidance 473. In Vitro Mammalian Chromosome Aberration Test In: OECD Guidance for Testing of Chemicals[S]. Paris: Organization for Economic Cooperation & Development, 1997. |
[17] |
田逸君. 雷公藤内酯醇的遗传毒性研究[D]. 第二军医大学, 2016. |
[18] |
田逸君, 张天宝, 朱玉平, 等. 聚乙二醇修饰降纤酶的遗传毒性评价[J]. 中国新药与临床杂志, 2012, 31(5):281-284. |
[19] |
张培培, 苏敏, 崔佳丽, 等. HPLC-MS/MS法测定Beagle犬血浆中灯盏乙素酶解产物灯盏乙素苷元[C]. 2016年第六届全国药物毒理学年会论文集, 2016. |
[20] |
严婷. 纤溶活性化合物FGFC1的药效学和毒理学的研究[D]. 上海: 上海海洋大学, 2014. |
[21] |
HONG Z Y, YU S S, WANG Z J, et al. SCM-198 ameliorates cognitive deficits, promotes neuronal survival and enhances CREB/BDNF/TrkB signaling without affecting aβ burden in AβPP/PS1 mice[J]. Int J Mol Sci,2015,16(8):18544-18563. doi: 10.3390/ijms160818544 |
[22] |
SONG X J, WANG T C, ZHANG Z C, et al. Leonurine exerts anti-inflammatory effect by regulating inflammatory signaling pathways and cytokines in LPS-induced mouse mastitis[J]. Inflammation,2015,38(1):79-88. doi: 10.1007/s10753-014-0009-9 |
[23] |
HUANG L Q, YANG X, PENG A L, et al. Inhibitory effect of leonurine on the formation of advanced glycation end products[J]. Food Funct,2015,6(2):584-589. doi: 10.1039/C4FO00960F |
[24] |
梁博志, 罗建华, 杨冬花, 等. 益母草碱作用及机制研究进展[J]. 贵阳中医学院学报, 2017, 39(4):93-96. |