米托蒽醌缓释复合人工骨体外释放度考察
Study on the dissolution of mitoxantrone in mitoxantron-hydroxylapatite ceramic composites in vitro
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摘要: 目的 考察羟基磷灰石陶瓷为药物载体、蜂蜡为阻滞剂制备的不同浓度蜂蜡包裹的米托蒽醌缓释复合人工骨(DHAQ-PHA-WAX)与未包裹蜂蜡的米托蒽醌人工骨(DHAQ-PHA)的体外释药规律。方法 可见分光光度法于660nm处测定包裹与未包裹蜂蜡的米托蒽醌-人工骨每天的释药量。结果 DHAQ-PHA与DHAQ-PHA-WAX的溶出速率有显着差异(P<005)。结论 DHAQ-PHA-WAX可有效地控制药物的释放。
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关键词:
- 羟基磷灰石复合人工骨 /
- 蜂蜡 /
- 米托蒽醌 /
- 溶出速率
Abstract: OBJECTIVE To investigate the drug-releasing regularity in vitro of variable concentration mitoxantrone,which wax in a matoxantrone hydroxylapatite ceramic composite encapsulated with wax (DHAQ-PHA-WAX) and DHAQ-PHA without the wax.hydroxylapatite ceramic was used as drug carrier and wax as inhibitor. METHODS The released drug concentration per-day was determined by visible spectrometry at λ =660nm. RESULTS There was a significant difference (P<0.05) between DHAQ-PHA dissolution velocity and DHAQ-PHA-WAX. CONCLUTION Releasing of DHAQ could be controlled with DHAQ-PHA-WAX.-
Key words:
- hydroxylapatite ceramic composite /
- wax /
- mitoxantrone /
- rate of drug-releasing
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