RP-HPLC法测定盐酸恩丹西酮氯化钠注射液的含量
Determination of ondansetron hydrochloride in natrium chloride infusion by a reversed-phase high performance liquid chromatography
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摘要: 目的 建立反相高效液相色谱法测定盐酸恩丹西酮氯化钠注射液含量的方法。方法 采用ODS反相柱,流动相为甲醇-0.02M磷酸二氢钾 (58:42,pH=6.0),检测波长为 308nm.结果 盐酸昂丹司琼在辅料中的回收率为 100.14%,日内与日间精密度分别为 0.41%与 0.54%.结论 本法准确、快捷,适用于测定盐酸恩丹西酮氯化钠注射液的含量。Abstract: OBJECTIVE To establish a new method to determin ondansetron in a natrium chloride infusion.METHLDS A reversed phase high performance liquid chromatography was employed. The mobile phase was composed of methanol and 0.02M KH2PO4 solution(58:42,pH=6.0).ODS was the stable phase.RESULTS Recovery was 100.14%.Between-day and Within-day precision was 0.41% and 0.54% respectively.CONCLUSION The method was rapid and correct.It is suitable for the determination of ondansetron in natrium chloride infusion.
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Key words:
- ondansetron /
- determination /
- RP-HPLC
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