氧氟沙星漱口液的研制及稳定性考察
Studies on ofloxacin gargle preparation and its stability
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摘要: 目的: 配制氧氟沙星漱口液, 并考察其稳定性。 方法: 通过参考有关资料确定处方、制备方法, 并采用紫外分光光度法测定其氧氟沙星含量, 采用初均速法考察其稳定性。 结果: 初均速法考察稳定性, 线性关系良好, 预测其室温有效期为t0.9=310d。氧氟沙星回收率为99.6%, RSD=2.0%(n=5)。 结论: 该制剂稳定性良好, 可作为临床辅助治疗药物。Abstract: Objective: To prepare ofloxacin gargle and observe its stability. Methods: Referring to relative literature, the formula and preparing procedure of ofloxacin gargle were established, the stability of the gargle was observed by using initial average rate meth-od. Results: The linear relationship was good in the initial average rate method.The expective effective time at room temperature (t0.9) was was more than 310 days.Ofloxacin's recycle rate was 99.6%. Conclusion: The preparation has good stability, and can be used as clinical therapeutic medicine.
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