Abstract: Objective :To assess the drug utilization and tendency of progress of oral hypoglycemic agents in our hospital and to provide references for rational administration clinically. Methods :DDDs,sales quantities,sales expenses and the ratio of sales expenses sequencing to that of DDDs in our hospital during the period of 2003-2005 were analyzed statistically with the method of DDDs analysis. Results :The top two antidiabetic drugs according to DDDs were melbine （dimethyl diguanide） and gliclazide three successive years.The DDDs of acarbose increased dramatically.Which blood glucose regulatsry drugs ranked lower,the ratio of sales expenses sequencing to that of DDDs of glipizide and gliclazide controlled release pellets was equal or about,whereas that of rosiglitazone,acarbose （glucobay） and glimepiride was less than 1. Conclusion :The study shows that the drug utilization of oral hypoglycemic agents in our hospital is basically rational and is in accordance with the trend of advancement and drug therapeutic strategies of diabetes mellitus.