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肝脏是人体内重要的实质器官,在新陈代谢、排毒和天然免疫中发挥关键作用[1-2]。酒精、药物、病毒等是肝损伤的暴露因素,在这些损伤因素的作用下,肝细胞易发生坏死进而导致肝损伤。肝损伤过程中会引发炎症,持续的肝脏炎症将导致肝纤维化,肝纤维化的持续发展将转变为肝硬化,甚至发展为肝癌。信号转导和转录激活因子3(signal transduction and transcriptional activator 3,STAT3)是体内重要的转录因子,在细胞生长、增殖和分化等生物过程中发挥关键作用。研究发现,STAT3的激活与肝损伤、炎症、肝再生、肝纤维化甚至肝癌密切相关。本文综述了STAT3在不同肝病中的研究进展,并讨论了STAT3抑制剂在治疗肝病中的潜在应用前景。
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