[1] |
FORCINA G C, DIXON S J. GPX4 at the crossroads of lipid homeostasis and ferroptosis[J]. Proteomics, 2019, 19(18):e1800311. |
[2] |
XIE Y C, KANG R, KLIONSKY D J, et al. GPX4 in cell death, autophagy, and disease[J]. Autophagy, 2023, 19(10):2621-2638. |
[3] |
GALLUZZI L, VITALE I, AARONSON S A, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018[J]. Cell Death Differ, 2018, 25(3):486-541. |
[4] |
ZHAO Y C, LI Y Q, ZHANG R F, et al. The role of erastin in ferroptosis and its prospects in cancer therapy[J]. Onco Targets Ther, 2020, 13:5429-5441. |
[5] |
SCHEERER P, BORCHERT A, KRAUSS N, et al. Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4(GPx4)[J]. Biochemistry, 2007, 46(31):9041-9049. |
[6] |
SAVASKAN N E, UFER C, KÜHN H, et al. Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function[J]. Biol Chem, 2007, 388(10):1007-1017. |
[7] |
YANG W S, STOCKWELL B R. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells[J]. Chem Biol, 2008, 15(3):234-245. |
[8] |
YANG W S, SRIRAMARATNAM R, WELSCH M E, et al. Regulation of ferroptotic cancer cell death by GPX4[J]. Cell, 2014, 156(1-2):317-331. |
[9] |
LIU H, FOROUHAR F, LIN A J, et al. Small-molecule allosteric inhibitors of GPX4[J]. Cell Chemical Biology, 2022, 29(12):1680-93. |
[10] |
WEÏWER M, BITTKER J A, LEWIS T A, et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS[J]. Bioorg Med Chem Lett, 2012, 22(4):1822-1826. |
[11] |
CHEN T T, LENG J F, TAN J, et al. Discovery of novel potent covalent glutathione peroxidase 4 inhibitors as highly selective ferroptosis inducers for the treatment of triple-negative breast cancer[J]. J Med Chem, 2023, 66(14):10036-10059. |
[12] |
XU C J, XIAO Z H, WANG J, et al. Discovery of a potent glutathione peroxidase 4 inhibitor as a selective ferroptosis inducer[J]. J Med Chem, 2021, 64(18):13312-13326. |
[13] |
EATON J K, RUBERTO R A, KRAMM A, et al. Diacylfuroxans are masked nitrile oxides that inhibit GPX4 covalently[J]. J Am Chem Soc, 2019, 141(51):20407-20415. |
[14] |
EATON J K, FURST L, RUBERTO R A, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles[J]. Nat Chem Biol, 2020, 16(5):497-506. |
[15] |
SHIMADA K, SKOUTA R, KAPLAN A, et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis[J]. Nat Chem Biol, 2016, 12(7):497-503. |
[16] |
GASCHLER M M, ANDIA A A, LIU H R, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation[J]. Nat Chem Biol, 2018, 14(5):507-515. |