Progress on micro-needles transdermal drug delivery system

WAN Zhan; ZHOU Jian; HAN Mei-na; YANG Feng

doi:10.3969/j.issn.1006-0111.2012.02.002

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Volume 30 Issue 2

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2012 > 30(2): 86-88,142

WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002

Citation:

WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002

Progress on micro-needles transdermal drug delivery system

doi: 10.3969/j.issn.1006-0111.2012.02.002

1.
School of Basic Medical Sciences, Hebei North University, Zhangjiakou 075000, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2.
School of Pharmacy, Chongqing Medical University, Chongqing 400331, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China
3.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2011-09-01
Rev Recd Date: 2011-12-06

Abstract

Micro-needles transdermal drug delivery system became the hot spot in the field of transdermal drug delivery system, which had the double advantages in both injection drug delivery and transdermal drug delivery. It also had the merits of fast absorption, continence and painless utility in clinical. Research indicated both transdermal speed and dose of drugs were highly increased when micro-needles transdermal drug delivery system was applied, which especially showed outstanding effects and promise in the preparation of drugs composed of protein, polypeptide, DNA and RNA, etc. Latest developments of micro-needles transdermal drug delivery system were reviewed in this paper. With the development of the industrial arts of the micro-needle, drug delivery technology and application research, micro-needles transdermal drug delivery system would be extensively employed in clinical field.
- Micro-needles,
- transdermal drug delivery,
- application

References

[1]	Henry S, McAllister DV, Allen MG, et al. Microfabricated microneedles : a novel approach to transdermal drug delivery[J]. J Pharmacol Sci,1998,87(8):922.
[2]	Mark RP, Robert L. Transdermal drug delivery[J].Nat Biotechnol,2008,26(11):1261.
[3]	Kalluri H, Banga AK. Transdermal delivery of proteins[J]. AAPS Pharmscitech, 2011.12(1):431.
[4]	Zhu QY,Zarnitsyn VG,Ye L,et al.Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge[J].Proc Natl Acad Sci USA,2009,106(19):7968.
[5]	Kaushik S, Hord AH, Denson DD, et al. Lack of pain associated with microfabricated microneedles[J]. Anesth.Analg,2001,92(2):502.
[6]	Ding Z,Riet V,Romeijn S,et al.Immune modulation by adjuvants combined with diphtheria toxoid administered topically in BALB／c mice after microneedle array pretreatment [J].Pharm Res,2009,26(7):163.
[7]	Sullivan SP, Koutsonanos DG,Del Pilar Martin M, et al.Dissolving polymer microneedle patches for influenza vaccination[J].Nat Med,2010,16(8):915.
[8]	Quan FS,Kim YC, Compans RW,et al. Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles[J].J Controlled Release,2010,147(3):326.
[9]	Hiraishi Y,Nandakumar S,Choi SO,et al.Bacillus Calmette-Guerin vaccination using a microneedle patch[J].Vaccine,2011,29(14):2626.
[10]	Nordquist L,Roxhed N,Griss P,et al.ovel microneedle patches for active insulin delivery are efficientin maintaining glycaemic control:an initial comparison with ubcutaneous administration[J].Pharm Res,2007,24(7):1381.
[11]	Chen HB, Zhu HD,Zheng JN,et al. Iontophoresis-driven penetration of nanovesicles through microneedle induced skin microchannels for enhancing transdermal delivery of insulin[J]. J Controlled Release,2009,139(1):63.
[12]	Gupta J,Felner EI,Prausnitz MR.Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects[J].Diabetes Technol Ther,2011 13(4):451.
[13]	You X,Chang Jong-hyeon,Ju Byeong-Kwon,et al.Rapidly dissolving fibroin microneedles for transdermal drug delivery[J]. Mater Sci Eng.,C 2011,31(8):1632.
[14]	Qin G, Gao Y, Wu Y,et al.Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management[J].Nanomedicine:NBM 2011,doi: 10.1016/j.nano.2011.05.017.
[15]	Harvey AJ,Kaestner SA,Sutter DE,et al.Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs[J].Pharm Res,2011,28(1):107.
[16]	Pearton M, Allender C, Brain K,et al.Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations[J]. Pharm Res,2008,25(2):407.
[17]	Gill HS, Soderholm J,Prausnitz MR,et al.Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine[J]. Gene Ther,2010,17(6):811.
[18]	Chen X,Kask AS,Crichton ML,et al.Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays[J].J Controlled Release,2010,148(3):321.
[19]	Kask AS,Chen X,Marshak JO,et al.DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge[J].Vaccine,2010,28(47):7483.
[20]	Gonzalez-Gonzalez E, Speaker TJ,Hickerson RP,et al.Silencing of reporter gene expression in skin using siRNAs and Expression of plasmid DNA delivered by a soluble protrusion array device[J]. Mol Ther,2010,18(9):1667.
[21]	Donnelly RF,Morrow DI,Fay F,et al.Microneedle-mediated intradermal nanoparticle delivery:potential for enhanced local administration of hydrophobic pre-formed photosensitisers[J].Photodiagnosis Photodyn Ther,2010,7(4):222.
[22]	Ito Y,Murano H,Hamasaki N,et al.Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles[J].Int J Pharm,2011,407(1-2):126.
[23]	Baek C,Han M,Min J,et al.Local transdermal delivery of phenylephine to the anal sphincter muscle using microneedles[J].J Controlled Release,2011,154(2):138.
[24]	Milewski M,Yerramreddy TR,Ghosh P,et al.In vitro permeation of apegylated naltrexone prodrug across microneedle-treated skin[J].J Controlled Release,2010,146(1):37.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Progress on micro-needles transdermal drug delivery system

1. School of Basic Medical Sciences, Hebei North University, Zhangjiakou 075000, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. School of Pharmacy, Chongqing Medical University, Chongqing 400331, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

3. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2011-09-01

Rev Recd Date: 2011-12-06

Key words:

Abstract: Micro-needles transdermal drug delivery system became the hot spot in the field of transdermal drug delivery system, which had the double advantages in both injection drug delivery and transdermal drug delivery. It also had the merits of fast absorption, continence and painless utility in clinical. Research indicated both transdermal speed and dose of drugs were highly increased when micro-needles transdermal drug delivery system was applied, which especially showed outstanding effects and promise in the preparation of drugs composed of protein, polypeptide, DNA and RNA, etc. Latest developments of micro-needles transdermal drug delivery system were reviewed in this paper. With the development of the industrial arts of the micro-needle, drug delivery technology and application research, micro-needles transdermal drug delivery system would be extensively employed in clinical field.

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Reference (24)

[1]	Henry S, McAllister DV, Allen MG, et al. Microfabricated microneedles : a novel approach to transdermal drug delivery[J]. J Pharmacol Sci,1998,87(8):922.
[2]	Mark RP, Robert L. Transdermal drug delivery[J].Nat Biotechnol,2008,26(11):1261.
[3]	Kalluri H, Banga AK. Transdermal delivery of proteins[J]. AAPS Pharmscitech, 2011.12(1):431.
[4]	Zhu QY,Zarnitsyn VG,Ye L,et al.Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge[J].Proc Natl Acad Sci USA,2009,106(19):7968.
[5]	Kaushik S, Hord AH, Denson DD, et al. Lack of pain associated with microfabricated microneedles[J]. Anesth.Analg,2001,92(2):502.
[6]	Ding Z,Riet V,Romeijn S,et al.Immune modulation by adjuvants combined with diphtheria toxoid administered topically in BALB／c mice after microneedle array pretreatment [J].Pharm Res,2009,26(7):163.
[7]	Sullivan SP, Koutsonanos DG,Del Pilar Martin M, et al.Dissolving polymer microneedle patches for influenza vaccination[J].Nat Med,2010,16(8):915.
[8]	Quan FS,Kim YC, Compans RW,et al. Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles[J].J Controlled Release,2010,147(3):326.
[9]	Hiraishi Y,Nandakumar S,Choi SO,et al.Bacillus Calmette-Guerin vaccination using a microneedle patch[J].Vaccine,2011,29(14):2626.
[10]	Nordquist L,Roxhed N,Griss P,et al.ovel microneedle patches for active insulin delivery are efficientin maintaining glycaemic control:an initial comparison with ubcutaneous administration[J].Pharm Res,2007,24(7):1381.
[11]	Chen HB, Zhu HD,Zheng JN,et al. Iontophoresis-driven penetration of nanovesicles through microneedle induced skin microchannels for enhancing transdermal delivery of insulin[J]. J Controlled Release,2009,139(1):63.
[12]	Gupta J,Felner EI,Prausnitz MR.Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects[J].Diabetes Technol Ther,2011 13(4):451.
[13]	You X,Chang Jong-hyeon,Ju Byeong-Kwon,et al.Rapidly dissolving fibroin microneedles for transdermal drug delivery[J]. Mater Sci Eng.,C 2011,31(8):1632.
[14]	Qin G, Gao Y, Wu Y,et al.Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management[J].Nanomedicine:NBM 2011,doi:10.1016/j.nano.2011.05.017.
[15]	Harvey AJ,Kaestner SA,Sutter DE,et al.Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs[J].Pharm Res,2011,28(1):107.
[16]	Pearton M, Allender C, Brain K,et al.Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations[J]. Pharm Res,2008,25(2):407.
[17]	Gill HS, Soderholm J,Prausnitz MR,et al.Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine[J]. Gene Ther,2010,17(6):811.
[18]	Chen X,Kask AS,Crichton ML,et al.Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays[J].J Controlled Release,2010,148(3):321.
[19]	Kask AS,Chen X,Marshak JO,et al.DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge[J].Vaccine,2010,28(47):7483.
[20]	Gonzalez-Gonzalez E, Speaker TJ,Hickerson RP,et al.Silencing of reporter gene expression in skin using siRNAs and Expression of plasmid DNA delivered by a soluble protrusion array device[J]. Mol Ther,2010,18(9):1667.
[21]	Donnelly RF,Morrow DI,Fay F,et al.Microneedle-mediated intradermal nanoparticle delivery:potential for enhanced local administration of hydrophobic pre-formed photosensitisers[J].Photodiagnosis Photodyn Ther,2010,7(4):222.
[22]	Ito Y,Murano H,Hamasaki N,et al.Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles[J].Int J Pharm,2011,407(1-2):126.
[23]	Baek C,Han M,Min J,et al.Local transdermal delivery of phenylephine to the anal sphincter muscle using microneedles[J].J Controlled Release,2011,154(2):138.
[24]	Milewski M,Yerramreddy TR,Ghosh P,et al.In vitro permeation of apegylated naltrexone prodrug across microneedle-treated skin[J].J Controlled Release,2010,146(1):37.

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Progress on micro-needles transdermal drug delivery system

doi: 10.3969/j.issn.1006-0111.2012.02.002

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通讯作者: 陈斌, bchen63@163.com

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