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Volume 30 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(2): 100-102

LIU Tao-fang, TANG Hua, GONG Wei, SUN Peng, LIU Bao-shu, LI Ling, ZHANG Wen. Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 100-102. doi: 10.3969/j.issn.1006-0111.2012.02.006
Citation: LIU Tao-fang, TANG Hua, GONG Wei, SUN Peng, LIU Bao-shu, LI Ling, ZHANG Wen. Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 100-102. doi: 10.3969/j.issn.1006-0111.2012.02.006
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Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida

doi: 10.3969/j.issn.1006-0111.2012.02.006

  • Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2011-05-27
  • Rev Recd Date: 2012-01-01
  • Objective To study the chemical constituents of the South China Sea gorgonian Muriceopsis flavida. Methods The compounds were isolated and purified by repeated column chromatographies including normal-phase silica gel, Sephadex LH-20 and semi-preparative RP-HPLC. The structures were elucidated by the physicochemical evidences and spectra data. The in vitro bio-activities of the compounds were assessed by an agar diffusion test. Results Two sesquiterpenes were isolated and indentified as menverins C (1) and D (2). The two compounds showed different levels of antimicrobial activity in bioassay in vitro. In particular, compounds 1 and 2 displayed considerable growth inhibition toward bacterium Bacillus migaterium and the alga Chlorella fusca, respectively. Conclusions This was the first report of menverins C (1) and D (2) from the genus Muriceopsis. The antimicrobial activity of both compounds suggested a possible ecological role of these metabolites in the chemical defensive strategy of the gorgonian.
  • [1] 黄宗国. 中国海洋生物种类与分布[M]. 北京: 海洋出版社, 2008: 300.
    [2] 邱蕴绮, 漆淑华, 张 偲. 柳珊瑚中甾醇类化合物及其生物活性研究进展[J]. 中草药, 2009, 40(6): 985.
    [3] 张 文, 郭跃伟. 海洋生物柳珊瑚的化学成分及生物活性研究进展[J]. 中国天然药物, 2003, 1(2): 69.
    [4] Blunt JW, Copp BR, Hu WP, et al. Marine natural products[J]. Nat Prod Rep, 2011, 28(2): 196.
    [5] Zhang W, Guo YW, Gu YC. Secondary metabolites from the South China Sea invertebrates: chemistry and biological activity[J]. CurrMed Chem, 2006, 13 (17): 2041.
    [6] Kokke WCMC, Bihlin L, Fenical W, et al. Novel dinoflagaellate 4α-methylated sterols from four Caribbean gorgonians[J]. Phytochemistry, 1982, 21 (4): 881.
    [7] Zhang W, Guo YW, Mollo E, et al. Junceellonoids A and B, two new briarane diterpenoids from the Chinese gorgonian Junceella fragilis ridley[J]. Helv Chim Acta, 2004, 87(9): 2341.
    [8] Zhang W, Huang H, Ding Y, et al. Three new polyoxygented steroids from the species of the South China Sea gorgonian Muricella flexuosa and Menella verrucosa brundin[J]. Helv Chim Acta, 2006, 89(4): 813.
    [9] Zhang W, Guo YW, Mollo E, et al. Acanthovagasteroids A-D, four new 19-hydroxylated steroids from the South China Sea gorgonian Acanthogorgia vagae aurivillius[J]. J Nat Prod, 2004, 67 (12): 2083.
    [10] Zhang W, Guo YW, Gavagnin M, et al. Suberoretisteroids A-E, five new uncommon polyoxygenated steroid 24-ketals from the Hainan gorgonian Suberogorgia reticulata[J]. Helv Chim Acta, 2005, 88 (1): 87.
    [11] 徐圆缘, 李 玲, 易杨华, 等. 块花柳珊瑚化学成分的研究[J]. 第二军医大学学报, 2010, 31 (4): 421.
    [12] 刘桃芳, 汤 华, 李 玲, 等. 中国南海紫柳珊瑚中过氧化甾醇类化学成分的研究[J]. 第二军医大学学报, 2011, 32(5): 469.
    [13] Zhang W, Guo YW, Ernesto M, et al. Menverins A-D, new highly oxygenated guaiane lactones from Hainan gorgonian Menella verrucosa[J]. Helv Chim Acta, 2004, 87: 2919.
    [14] Li L, Wang CY, Mollo H, et al. Futher highly oxygenated guaiane lactones from the South China Sea gorgonian Menella sp[J]. Helv Chim Acta, 2008, 91(1): 111.
    [15] 郭 奇, 魏玉西, 王长云, 等. 枝网刺柳珊瑚Echinogorgia sassapo reticulate (Esper)的化学成分研究[J]. 中国海洋药物杂志, 2010, 29 (1): 32.
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Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida

doi: 10.3969/j.issn.1006-0111.2012.02.006
  • Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2011-05-27
  • Rev Recd Date: 2012-01-01

Abstract: Objective To study the chemical constituents of the South China Sea gorgonian Muriceopsis flavida. Methods The compounds were isolated and purified by repeated column chromatographies including normal-phase silica gel, Sephadex LH-20 and semi-preparative RP-HPLC. The structures were elucidated by the physicochemical evidences and spectra data. The in vitro bio-activities of the compounds were assessed by an agar diffusion test. Results Two sesquiterpenes were isolated and indentified as menverins C (1) and D (2). The two compounds showed different levels of antimicrobial activity in bioassay in vitro. In particular, compounds 1 and 2 displayed considerable growth inhibition toward bacterium Bacillus migaterium and the alga Chlorella fusca, respectively. Conclusions This was the first report of menverins C (1) and D (2) from the genus Muriceopsis. The antimicrobial activity of both compounds suggested a possible ecological role of these metabolites in the chemical defensive strategy of the gorgonian.

LIU Tao-fang, TANG Hua, GONG Wei, SUN Peng, LIU Bao-shu, LI Ling, ZHANG Wen. Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 100-102. doi: 10.3969/j.issn.1006-0111.2012.02.006
Citation: LIU Tao-fang, TANG Hua, GONG Wei, SUN Peng, LIU Bao-shu, LI Ling, ZHANG Wen. Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 100-102. doi: 10.3969/j.issn.1006-0111.2012.02.006
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