CAO Wei-wei, XU Jiang-ping, ZHAO Na-ping, WANG Jing, ZHANG Li. Effects of total aglycone of centella asiatica on depressed rats by chronic unpredicted mild stress[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 121-124. doi: 10.3969/j.issn.1006-0111.2012.02.012
| Citation:
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CAO Wei-wei, XU Jiang-ping, ZHAO Na-ping, WANG Jing, ZHANG Li. Effects of total aglycone of centella asiatica on depressed rats by chronic unpredicted mild stress[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 121-124. doi: 10.3969/j.issn.1006-0111.2012.02.012
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Effects of total aglycone of centella asiatica on depressed rats by chronic unpredicted mild stress
- 1.
Department of Pharmacy, No.411th Hospital of PLA, Shanghai 200081, China
- 2.
Department of Pharmacology, School of Pharmacy, Southern Medical University, Guangzhou 510515, China
- 3.
Department of Pharmacy, Changhai Hospital affiliated to Second military medical university, Shanghai 200433, China
- Received Date: 2011-02-14
- Rev Recd Date:
2011-10-08
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Abstract
Objective To investigate effects of total aglycone of centella asiatica on depressed rats and study plasma levels of adrenocorticotropic hormone (ACTH) and cortisol (CORT). Methods The chronic mild stress depressed rats were produced by long-term unpredicted mild stress. The behavior of rats was detected by open field test. Objective index of anhedonia were sucrose water consumption and preference percentage of sucrose water in liquid consumption test. The levels of plasma ACTH and CORT were measured by radioimmunoassay. Results The depressed rats experienced less squares crossed, rears in the open-field test. Sucrose consumption in the sucrose preference test decreased significantly. The concentration of plasma ACTH and CORT significantly increased in stress-model rats compared to the control rats. The behavioral disorders and the levels of plasma ACTH and CORT of rats were improved by total aglycone of centella asiatica significantly. Conclusion Total aglycone of centella asiatica had anti-depressant effects, and which mechanism might be related to the improvement of hypothalamus-pituitary gland-adrenal glands axis function.
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