GAO Yue, YANG Ling, WU Rong. Study on pharmacokinetics and relative bioavailability of nimodipine orally disintegrating tablet[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 197-202. doi: 10.3969/j.issn.1006-0111.2012.03.011
Citation:
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GAO Yue, YANG Ling, WU Rong. Study on pharmacokinetics and relative bioavailability of nimodipine orally disintegrating tablet[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 197-202. doi: 10.3969/j.issn.1006-0111.2012.03.011
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Study on pharmacokinetics and relative bioavailability of nimodipine orally disintegrating tablet
- Received Date: 2010-04-14
- Rev Recd Date:
2010-07-16
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Abstract
Objective To research the pharmacokinetics and relative bioavailability of Nimodipine rapid disintegeating tablet in human body, which was compared with Nimodipine market tablets. Methods 6 cases of health volunteer were divide into two groups randomly , alternately taking rapid disintegeating tablet A and market tablet B of Nimodipine 60mg single dosage orally, HPLC was used to determine the concentration of Nimodipine in blood. Results The main Pharmacokinetics parameters after single oral administration Nimodipine rapid disintegeating tablet A and Nimodipine market tablet B were (256.23±54.64) g/ml, (102.415±36.96) g/ml in Cmax; (0.7049±0.035) h, (1.3317±0.123) h in Tmax; (0.2734±0.031) h, (1.1958±0.141) h in T1/2; (622.77±98.03) g/(ml·h), (354.63±96.24) g/(ml·h) in AUC0 - t, respectively. The bioavailability of rapid disintegeating tablet was 177.27% relative to market tablet. Conclusion Nimodipine rapid disintegeating tablet was capable of releasing rapidly, and had an enhanced bioavailability as compared with market tablet.
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Proportional views
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