2012 Vol. 30, No. 3
Display Method:
2012, 30(3): 161-164,228.
doi: 10.3969/j.issn.1006-0111.2012.03.001
Abstract:
The morbidity of chronic diseases such as cardiovascular diseases, which were becoming the main mortality of human death, was increasing steadily. As a result of its multi-induced character, it was impossible to cure those kind of diseases by mono-therapy. Some experts announced the conception of multifunctional tablet called Polypill, which was more convenience, cost-effectiveness and could improve the drug adherence. The development and application prospects of Polypill were reviewed in this paper.
The morbidity of chronic diseases such as cardiovascular diseases, which were becoming the main mortality of human death, was increasing steadily. As a result of its multi-induced character, it was impossible to cure those kind of diseases by mono-therapy. Some experts announced the conception of multifunctional tablet called Polypill, which was more convenience, cost-effectiveness and could improve the drug adherence. The development and application prospects of Polypill were reviewed in this paper.
2012, 30(3): 165-167,225.
doi: 10.3969/j.issn.1006-0111.2012.03.003
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Objective To review the role of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells. Methods The relevant literatures were collected to make a summary of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells. Result and Conclusion Ribosomal Protein S3a played an important role in protein synthesis and also had unique extra-ribosomal functions, such as DNA repair, cell growth and cell differentiation. In recent years, it was found that the expression of Ribosomal Protein S3a was enhancedin tumor cells. It was involved in the regulation of proliferation, differentiation, and apoptosis of tumor cells by affecting the expression of oncogenes and tumor suppressor genes.
Objective To review the role of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells. Methods The relevant literatures were collected to make a summary of Ribosomal Protein S3a in regulation of proliferation, differentiation and apoptosis in tumor cells. Result and Conclusion Ribosomal Protein S3a played an important role in protein synthesis and also had unique extra-ribosomal functions, such as DNA repair, cell growth and cell differentiation. In recent years, it was found that the expression of Ribosomal Protein S3a was enhancedin tumor cells. It was involved in the regulation of proliferation, differentiation, and apoptosis of tumor cells by affecting the expression of oncogenes and tumor suppressor genes.
2012, 30(3): 168-170,202.
doi: 10.3969/j.issn.1006-0111.2012.03.004
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Natural repellent had the characteristic of safety, environmental friendliness, little toxicity and so on. Its research was mainly concentrated on screening the high active constituent. By searching literatures of recent years, the current situation about the formulation of mosquito repellent was summarized, in order to provide scientific basis for the research and development of mosquito repellent formulation.
Natural repellent had the characteristic of safety, environmental friendliness, little toxicity and so on. Its research was mainly concentrated on screening the high active constituent. By searching literatures of recent years, the current situation about the formulation of mosquito repellent was summarized, in order to provide scientific basis for the research and development of mosquito repellent formulation.
2012, 30(3): 171-174,177.
doi: 10.3969/j.issn.1006-0111.2012.03.005
Abstract:
Objective In recent years, with the worsening situation of the international nuclear crisis as well as people prolonged exposure to low doses of radiation in the surrounding environment in daily lives, the research on radio-protective drugs was much more crucial. Natural medicines and ethnic drugs were attended by researchers'eyes for their outstanding advantages such as rich resources, exactly curative effects and lower side effects. The research progress on common natural medicines and their active components as well as ethnic drugs that are usually used as anti-radiation drugs were reviewed in this paper.
Objective In recent years, with the worsening situation of the international nuclear crisis as well as people prolonged exposure to low doses of radiation in the surrounding environment in daily lives, the research on radio-protective drugs was much more crucial. Natural medicines and ethnic drugs were attended by researchers'eyes for their outstanding advantages such as rich resources, exactly curative effects and lower side effects. The research progress on common natural medicines and their active components as well as ethnic drugs that are usually used as anti-radiation drugs were reviewed in this paper.
2012, 30(3): 175-177.
doi: 10.3969/j.issn.1006-0111.2012.03.006
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Because of the urgent needs of the medical advances and clinical diagnosis practice, positron emission tomography drugs were increasingly widely researched and used. The characteristics and the course of the development of positron emission tomography drugs were reviewed at home and abroad. Based on the current status of positron emission tomography drugs in China, the ideas of promoting the research, production and clinical application of positron emission tomography drugs were also discussed in this paper.
Because of the urgent needs of the medical advances and clinical diagnosis practice, positron emission tomography drugs were increasingly widely researched and used. The characteristics and the course of the development of positron emission tomography drugs were reviewed at home and abroad. Based on the current status of positron emission tomography drugs in China, the ideas of promoting the research, production and clinical application of positron emission tomography drugs were also discussed in this paper.
2012, 30(3): 178-181.
doi: 10.3969/j.issn.1006-0111.2012.03.002
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Depression was a common mental disorder. Nowdays, anti-depressants included tricyclic antidepressants, monoamine oxidase inhibitors and reversible selective monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, selective noradrenergic reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, norepinephrine and dopamine reuptake inhibitors. The progress on drug treatment of depression were reviewed in this paper.
Depression was a common mental disorder. Nowdays, anti-depressants included tricyclic antidepressants, monoamine oxidase inhibitors and reversible selective monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, selective noradrenergic reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, norepinephrine and dopamine reuptake inhibitors. The progress on drug treatment of depression were reviewed in this paper.
2012, 30(3): 182-184.
doi: 10.3969/j.issn.1006-0111.2012.03.007
Abstract:
Objective To evaluate the clinical effect of Reduning injection in the pediatric disease. Methods The pertinent literatures on pediatrician using Reduning injection in recent years were reviewed and analyzed. Results and Conclusion Reduning injection had antibacterial and antiviral effect,which could improve the immune system. Reduning injection obtained remarkable effect in the treatment of acute upper respiratory tract infection,Community-acquired pneumonia,capillary bronchitis,herpes angina,acute suppurative tonsillitis,rotavirus enteritis,hand-foot-mouth disease,influenza H1N1,viral encephalitis,epidemic parotitis,varicella and measles,popularize in the clinic.
Objective To evaluate the clinical effect of Reduning injection in the pediatric disease. Methods The pertinent literatures on pediatrician using Reduning injection in recent years were reviewed and analyzed. Results and Conclusion Reduning injection had antibacterial and antiviral effect,which could improve the immune system. Reduning injection obtained remarkable effect in the treatment of acute upper respiratory tract infection,Community-acquired pneumonia,capillary bronchitis,herpes angina,acute suppurative tonsillitis,rotavirus enteritis,hand-foot-mouth disease,influenza H1N1,viral encephalitis,epidemic parotitis,varicella and measles,popularize in the clinic.
Stimulation of NFκB activity by the agonist inhibition from Lipoxin A4, Protectin D1 and Resolvin D1
2012, 30(3): 185-188.
doi: 10.3969/j.issn.1006-0111.2012.03.008
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Objective To examine effect of lipoxin A4 (LXA4), protectin D1 (ProD1) or resolvin D1 (RvD1) on the activity of NFκB and their action mechanism. Methods The CHO cells, stably expressing NFκB luciferase reporter gene, were treated with LPS, HSP70, HMGB1 or S100A4, in the presence or absence of 100 nmol/L of LXA4, ProD1 or RvD1 for 30 minutes. The activity of NFκB was detected with the luciferase assay. The content of tumor necrosis factor α (TNFα) in supernatant was measured by enzyme-1inked immunosorbent assay (ELISA) and the expression of NFκB in the nucleus was detected by immune blotting. Results The activity of NFκB and the level of TNFα in supernatant were significantly upregulated after treatment of the cells with LPS, HSP70, HMGB1 or S100A4, respectively. However, the NFκB activity and concentration of TNFα were lowered in the cells preincubated with LXA4, ProD1 or RvD1 as compared to the stimulated cells. Moreover, the lipids significantly decreased the content of NFκB in the nucleus. Conclusion LXA4, ProD1 or RvD1 could significantly inhibit the ligand-stimulated NFκB activity through interfering with NFκB translocation from cytoplast to nucleus. LXA4, ProD1 and RvD1 showed the potential in the development of new anti-inflammatory therapeutics, which was required further research.
Objective To examine effect of lipoxin A4 (LXA4), protectin D1 (ProD1) or resolvin D1 (RvD1) on the activity of NFκB and their action mechanism. Methods The CHO cells, stably expressing NFκB luciferase reporter gene, were treated with LPS, HSP70, HMGB1 or S100A4, in the presence or absence of 100 nmol/L of LXA4, ProD1 or RvD1 for 30 minutes. The activity of NFκB was detected with the luciferase assay. The content of tumor necrosis factor α (TNFα) in supernatant was measured by enzyme-1inked immunosorbent assay (ELISA) and the expression of NFκB in the nucleus was detected by immune blotting. Results The activity of NFκB and the level of TNFα in supernatant were significantly upregulated after treatment of the cells with LPS, HSP70, HMGB1 or S100A4, respectively. However, the NFκB activity and concentration of TNFα were lowered in the cells preincubated with LXA4, ProD1 or RvD1 as compared to the stimulated cells. Moreover, the lipids significantly decreased the content of NFκB in the nucleus. Conclusion LXA4, ProD1 or RvD1 could significantly inhibit the ligand-stimulated NFκB activity through interfering with NFκB translocation from cytoplast to nucleus. LXA4, ProD1 and RvD1 showed the potential in the development of new anti-inflammatory therapeutics, which was required further research.
2012, 30(3): 189-193.
doi: 10.3969/j.issn.1006-0111.2012.03.009
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Objective To optimize the preparation and study in vitro releasing of SRL-NLC dispersion. Methods Central composite design-response surface methodology was used to optimize dispersion formulation,then in vitro releasing in 0.4% SDS(sodium lauryl sulfate) solution was explored by normal phase dialysis bag method. Results The optimal dispersion had PS(particle size):82.54nm,PI(polydisperity index):0.207, Zeta potential: -18.0 mv,DL (drug-loading): 1.829%, and EE(entrapment efficiency): 91.3%; SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4%SDS solution. Conclusion The optimal formulation had good feasibility and reproducibility, in vitro releasing curve showed SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4% SDS solution.
Objective To optimize the preparation and study in vitro releasing of SRL-NLC dispersion. Methods Central composite design-response surface methodology was used to optimize dispersion formulation,then in vitro releasing in 0.4% SDS(sodium lauryl sulfate) solution was explored by normal phase dialysis bag method. Results The optimal dispersion had PS(particle size):82.54nm,PI(polydisperity index):0.207, Zeta potential: -18.0 mv,DL (drug-loading): 1.829%, and EE(entrapment efficiency): 91.3%; SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4%SDS solution. Conclusion The optimal formulation had good feasibility and reproducibility, in vitro releasing curve showed SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4% SDS solution.
2012, 30(3): 194-196.
doi: 10.3969/j.issn.1006-0111.2012.03.010
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Objective To identify different breeds of Fagopyrum tataricum by differential thermal analysis and near infrared reflectance spectroscopy. Methods TG/DTA and thermal analysis were both used to scan and analyze the thermal map of 11 breeds of F. tartaricum. The experiment conditions included DTA range of ±50 μV, a calefactive rate of 15 ℃/min, an ambience of nitrogen and flow velocity of 50 ml/min. Bruker Vector 22/N-type Fourier transform near infrared spectroscopy was used to scan and analyze of 11 breeds F. tartaricum. Experiment conditions were: integrating sphere diffuse reflectance as measure methods; scan for 64 times; 3 700 ~ 12 000/cm as scan range. Results Both methods could identify the Jiande tartary buckwheat from other breeds. Conclusion Jiande tartary buckwheat was a new cultivar, nutrient value and pharmacological activity of which should be evaluated for promotion.
Objective To identify different breeds of Fagopyrum tataricum by differential thermal analysis and near infrared reflectance spectroscopy. Methods TG/DTA and thermal analysis were both used to scan and analyze the thermal map of 11 breeds of F. tartaricum. The experiment conditions included DTA range of ±50 μV, a calefactive rate of 15 ℃/min, an ambience of nitrogen and flow velocity of 50 ml/min. Bruker Vector 22/N-type Fourier transform near infrared spectroscopy was used to scan and analyze of 11 breeds F. tartaricum. Experiment conditions were: integrating sphere diffuse reflectance as measure methods; scan for 64 times; 3 700 ~ 12 000/cm as scan range. Results Both methods could identify the Jiande tartary buckwheat from other breeds. Conclusion Jiande tartary buckwheat was a new cultivar, nutrient value and pharmacological activity of which should be evaluated for promotion.
2012, 30(3): 197-202.
doi: 10.3969/j.issn.1006-0111.2012.03.011
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Objective To research the pharmacokinetics and relative bioavailability of Nimodipine rapid disintegeating tablet in human body, which was compared with Nimodipine market tablets. Methods 6 cases of health volunteer were divide into two groups randomly , alternately taking rapid disintegeating tablet A and market tablet B of Nimodipine 60mg single dosage orally, HPLC was used to determine the concentration of Nimodipine in blood. Results The main Pharmacokinetics parameters after single oral administration Nimodipine rapid disintegeating tablet A and Nimodipine market tablet B were (256.23±54.64) g/ml, (102.415±36.96) g/ml in Cmax; (0.7049±0.035) h, (1.3317±0.123) h in Tmax; (0.2734±0.031) h, (1.1958±0.141) h in T1/2; (622.77±98.03) g/(ml·h), (354.63±96.24) g/(ml·h) in AUC0 - t, respectively. The bioavailability of rapid disintegeating tablet was 177.27% relative to market tablet. Conclusion Nimodipine rapid disintegeating tablet was capable of releasing rapidly, and had an enhanced bioavailability as compared with market tablet.
Objective To research the pharmacokinetics and relative bioavailability of Nimodipine rapid disintegeating tablet in human body, which was compared with Nimodipine market tablets. Methods 6 cases of health volunteer were divide into two groups randomly , alternately taking rapid disintegeating tablet A and market tablet B of Nimodipine 60mg single dosage orally, HPLC was used to determine the concentration of Nimodipine in blood. Results The main Pharmacokinetics parameters after single oral administration Nimodipine rapid disintegeating tablet A and Nimodipine market tablet B were (256.23±54.64) g/ml, (102.415±36.96) g/ml in Cmax; (0.7049±0.035) h, (1.3317±0.123) h in Tmax; (0.2734±0.031) h, (1.1958±0.141) h in T1/2; (622.77±98.03) g/(ml·h), (354.63±96.24) g/(ml·h) in AUC0 - t, respectively. The bioavailability of rapid disintegeating tablet was 177.27% relative to market tablet. Conclusion Nimodipine rapid disintegeating tablet was capable of releasing rapidly, and had an enhanced bioavailability as compared with market tablet.
2012, 30(3): 203-206,210.
doi: 10.3969/j.issn.1006-0111.2012.03.012
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Objective To design and synthesize novel 1-(1H-benzimidazole-2-yl)urea compounds on the basis of the active site of human acrosin. Methods The compounds were designed by computer modeling and synthesized. Results Ten 1-(1H-benzimidazole-2-yl)urea compounds were designed and synthesized, in vitro anti-acrosin activity were tested. Conclusions The results of in vitro anti-acrosin test showed that all the compounds had better acrosin inhibitory activity than that of the control compound TLCK.Among them compound 8a was the most potent one, with IC50 0.098 9 mmol/L.
Objective To design and synthesize novel 1-(1H-benzimidazole-2-yl)urea compounds on the basis of the active site of human acrosin. Methods The compounds were designed by computer modeling and synthesized. Results Ten 1-(1H-benzimidazole-2-yl)urea compounds were designed and synthesized, in vitro anti-acrosin activity were tested. Conclusions The results of in vitro anti-acrosin test showed that all the compounds had better acrosin inhibitory activity than that of the control compound TLCK.Among them compound 8a was the most potent one, with IC50 0.098 9 mmol/L.
2012, 30(3): 207-210.
doi: 10.3969/j.issn.1006-0111.2012.03.013
Abstract:
Objective To identify the volatile components in rat serum of Shexiang Baoxin Pill (SBP) by gas chromatography couples with mass spectrometry (GC-MS). Methods Serum samples from control and SBP administration rats were deproteinated by adding methanol prior to gas chromatography. The separation was carried out on a Thermo TR-5 ms column (30 m×0.25 mm I.D.). The inlet temperature was set at 220 ℃ and ion source temperature was 250 ℃ with gradient warming. The carrier gas was N2 with a gas flow rate of 1.0 ml/min, and the injection volume was 1μl. The total analysis time was 59min. The data acquisition were performed on Xcalibur workstation. Results Ten components including 6 components from SBP and 4 metabolites were observed from a comprehensive analysis of the chromatography of SBP solution. All the observed components were identified by using the online NIST05 library. Conclusion An integrated method for screening volatile bioactive components in serum after oral administration of SBP was established, which provided helpful information for further mechanism research.
Objective To identify the volatile components in rat serum of Shexiang Baoxin Pill (SBP) by gas chromatography couples with mass spectrometry (GC-MS). Methods Serum samples from control and SBP administration rats were deproteinated by adding methanol prior to gas chromatography. The separation was carried out on a Thermo TR-5 ms column (30 m×0.25 mm I.D.). The inlet temperature was set at 220 ℃ and ion source temperature was 250 ℃ with gradient warming. The carrier gas was N2 with a gas flow rate of 1.0 ml/min, and the injection volume was 1μl. The total analysis time was 59min. The data acquisition were performed on Xcalibur workstation. Results Ten components including 6 components from SBP and 4 metabolites were observed from a comprehensive analysis of the chromatography of SBP solution. All the observed components were identified by using the online NIST05 library. Conclusion An integrated method for screening volatile bioactive components in serum after oral administration of SBP was established, which provided helpful information for further mechanism research.
2012, 30(3): 211-212,215.
doi: 10.3969/j.issn.1006-0111.2012.03.014
Abstract:
Objective To discuss the protection and mechanism of Jianbu Guanjie Capusule( JBGJ capsule) to the knee osteoarthritis of rabbit. Methods Thirty healthy New Zealand rabbits were divided into five groups randomly with parallel control methods.The five groups were model group, positive group, low dose group, middle dose group and high dose group, respectively.The osteoarthropathy of knee joint model was built according to the Japanese KangYan standard.The rabbits were given the drug in the next day after the model establishment. After six weeks, animal serum and slippery membranes were collected to be detected. Results The activity of SOD in serum was improved in the middle, high dose group and positive group, which had significant different with the model group(P<0.05).The nitric oxide (NO) in serum was raised in low, middle and high dose group. The middle dose group had significant different with the model group. Conclusion JBGJ capsule could improve the activity of Superoxide dismutase (SOD) in serum and the level of NO, which could obviously improved the pathological alteration in osteoarthropathy model of rabbit.
Objective To discuss the protection and mechanism of Jianbu Guanjie Capusule( JBGJ capsule) to the knee osteoarthritis of rabbit. Methods Thirty healthy New Zealand rabbits were divided into five groups randomly with parallel control methods.The five groups were model group, positive group, low dose group, middle dose group and high dose group, respectively.The osteoarthropathy of knee joint model was built according to the Japanese KangYan standard.The rabbits were given the drug in the next day after the model establishment. After six weeks, animal serum and slippery membranes were collected to be detected. Results The activity of SOD in serum was improved in the middle, high dose group and positive group, which had significant different with the model group(P<0.05).The nitric oxide (NO) in serum was raised in low, middle and high dose group. The middle dose group had significant different with the model group. Conclusion JBGJ capsule could improve the activity of Superoxide dismutase (SOD) in serum and the level of NO, which could obviously improved the pathological alteration in osteoarthropathy model of rabbit.
Therapeutic effect of Tiotropium bromide on moderate to severe chronic obstructive pulmonary disease
2012, 30(3): 213-215.
doi: 10.3969/j.issn.1006-0111.2012.03.015
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Objective To investigate the effectiveness and safety of the inhalation of tiotropium bromide in the treatment of moderate to severe chronic obstructive pulmonary disease. Methods 35 cases with chronic obstructive pulmonary disease during 2010 June to 2011 November in our department were observed which was used by tiotropium bromide dry powder (Spirva, 18 μg, once daily) . The pulmonary function, average daily use of beta agonists times and cardiopulmonary insufficiency in patients with Plasma brain natriuretic peptide levels(BNP)were compared before treatment and three months after the treatment. The number of admissions three months before treatment and three months after treatment was recorded,and the adverse reaction observed. Results Tiotropium pulmonary function was improved significantly, the number of daily use of beta agonists reduced, peripheral blood BNP decreased obviously, the number of acute exacerbation of seizures became less,no serious adverse reaction occurred. Conclusion Tiotropium bromide was effectiveness and safety in moderate to severe chronic obstructive pulmonary disease.
Objective To investigate the effectiveness and safety of the inhalation of tiotropium bromide in the treatment of moderate to severe chronic obstructive pulmonary disease. Methods 35 cases with chronic obstructive pulmonary disease during 2010 June to 2011 November in our department were observed which was used by tiotropium bromide dry powder (Spirva, 18 μg, once daily) . The pulmonary function, average daily use of beta agonists times and cardiopulmonary insufficiency in patients with Plasma brain natriuretic peptide levels(BNP)were compared before treatment and three months after the treatment. The number of admissions three months before treatment and three months after treatment was recorded,and the adverse reaction observed. Results Tiotropium pulmonary function was improved significantly, the number of daily use of beta agonists reduced, peripheral blood BNP decreased obviously, the number of acute exacerbation of seizures became less,no serious adverse reaction occurred. Conclusion Tiotropium bromide was effectiveness and safety in moderate to severe chronic obstructive pulmonary disease.
2012, 30(3): 216-217.
doi: 10.3969/j.issn.1006-0111.2012.03.016
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Objective To design and synthesize octane-4,5-dione, decane-5,6-dione and dodecane-6, 7-dione with ethyl butyrate, ethyl pentannate and ethyl hexanoate as the corresponding starting materials. Methods TTarget products were synthesized by coupling reaction in the presence of sodium firstly and oxidation reaction with copper acetate secondly. Results octane-4,5-dione,decane-5,6-dione and dodecane-6,7 were synthesized. Conclusions The synthetic method was feasible and simple.
Objective To design and synthesize octane-4,5-dione, decane-5,6-dione and dodecane-6, 7-dione with ethyl butyrate, ethyl pentannate and ethyl hexanoate as the corresponding starting materials. Methods TTarget products were synthesized by coupling reaction in the presence of sodium firstly and oxidation reaction with copper acetate secondly. Results octane-4,5-dione,decane-5,6-dione and dodecane-6,7 were synthesized. Conclusions The synthetic method was feasible and simple.
2012, 30(3): 218-219.
doi: 10.3969/j.issn.1006-0111.2012.03.017
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Objective To study the relationship between steady-state plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose. Methods 148 schizophrenia patients were treated with quetiapine with the same dose (600 mg/d). The clinical efficacy and adverse reactions were evaluated with BPRS and TESS respectively, while the plasma concentration of quetiapine was tested at 2nd, 4th and 8th weekend. Results The plasma concentration of quetiapine had significant difference with the reduced rate of BPRS (P<0.05), but had no difference with the scores of TESS. Conclusions The testing of plasma concentration could help to distinguish the effective and toxic concentration of quetiapine in treatment of schizophrenia, which could help doctors to choose rational dose of quetiapine for each patients.
Objective To study the relationship between steady-state plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose. Methods 148 schizophrenia patients were treated with quetiapine with the same dose (600 mg/d). The clinical efficacy and adverse reactions were evaluated with BPRS and TESS respectively, while the plasma concentration of quetiapine was tested at 2nd, 4th and 8th weekend. Results The plasma concentration of quetiapine had significant difference with the reduced rate of BPRS (P<0.05), but had no difference with the scores of TESS. Conclusions The testing of plasma concentration could help to distinguish the effective and toxic concentration of quetiapine in treatment of schizophrenia, which could help doctors to choose rational dose of quetiapine for each patients.
2012, 30(3): 220-221.
doi: 10.3969/j.issn.1006-0111.2012.03.018
Abstract:
Objective To establish the best manufacturing technology of compound Fructus crataegi granule. Method The craft of manufacturing between swing prilling and atomizing prilling was studied. The output , properties, solution in water and total flavonoids were taken as test index. Result The output reached 130 kg, the granule was hole shape, uniformly sized and good fluidity after adopting the atomizing prilling. Conclusion The atomizing prilling was better than swing prilling in manufacturing.
Objective To establish the best manufacturing technology of compound Fructus crataegi granule. Method The craft of manufacturing between swing prilling and atomizing prilling was studied. The output , properties, solution in water and total flavonoids were taken as test index. Result The output reached 130 kg, the granule was hole shape, uniformly sized and good fluidity after adopting the atomizing prilling. Conclusion The atomizing prilling was better than swing prilling in manufacturing.
2012, 30(3): 222-225.
doi: 10.3969/j.issn.1006-0111.2012.03.019
Abstract:
Objective To establish and optimize a simple, rapid, reliable, high sensitive and high selective method for the determination of fluoxetine hydrochloride in plasma by high-performance liquid chromatographic (HPLC) so as to monitor the clinical drug use. Methods The plasma samples were deproteined by acetonitrile. Separation was performed on a Hypersil ODS2 column(5 μm, 4.6 mm×200 mm). The mobile phase contained acetonitrile-25 mmol/ L phosphate buffer(pH6.5)(34:66). The flow rate and sample volume injected were 1.2 ml/min and 20 μl, respectively. Detection wavelength was 227 nm. Results The calibration curve of fluoxetine hydrochloride in plasma was linear in the concentration range of 0.5~50 ng/ml and coefficient was 0.996 9. The intra-assay precision did not exceed 8.06% and inter-assay precision did not exceed 10.46% for low, medium and high quality samples, respectively. The average recovery of the described method was 91.7%,97.06% and 100.75%, respectively. Conclusion In comparison with previous work, the improved chromatographic method was more economical, less polluted and better protected column, besides simple preparation of plasma samples, high reproducibility, and high selectivity.
Objective To establish and optimize a simple, rapid, reliable, high sensitive and high selective method for the determination of fluoxetine hydrochloride in plasma by high-performance liquid chromatographic (HPLC) so as to monitor the clinical drug use. Methods The plasma samples were deproteined by acetonitrile. Separation was performed on a Hypersil ODS2 column(5 μm, 4.6 mm×200 mm). The mobile phase contained acetonitrile-25 mmol/ L phosphate buffer(pH6.5)(34:66). The flow rate and sample volume injected were 1.2 ml/min and 20 μl, respectively. Detection wavelength was 227 nm. Results The calibration curve of fluoxetine hydrochloride in plasma was linear in the concentration range of 0.5~50 ng/ml and coefficient was 0.996 9. The intra-assay precision did not exceed 8.06% and inter-assay precision did not exceed 10.46% for low, medium and high quality samples, respectively. The average recovery of the described method was 91.7%,97.06% and 100.75%, respectively. Conclusion In comparison with previous work, the improved chromatographic method was more economical, less polluted and better protected column, besides simple preparation of plasma samples, high reproducibility, and high selectivity.
2012, 30(3): 226-228.
doi: 10.3969/j.issn.1006-0111.2012.03.020
Abstract:
Objective To establish an HPLC method for the determination of Tectoridin and Tectorigenin in Flos Puerariae lobata. Method The separation was performed on Agilent -C18 column(4.6 mm×250 mm,5 μm),using a mobile phase with methanol-acetonitrile-water(2∶1∶2). Flow rate was 1.0ml/min,the detection wavelength was set at 264 nm. Column temperature was ambient temperature. Result The linear range of tectoridin was 2.0 ~120.0 μg/ml,r=0.999 8.The average recovery was 99.7%,RSD was 1.9%;The linear range of tectorigenin was 0.8 ~80.0 μg/ml,r=0.998 6.The average recovery was 99.4%,RSD was 1.7%. Conclusion The method was simple ,accurate,reliable with a good repeatability,which could be used to determinate of tectoridin and tectorigenin in Flos Puerariae lobata.
Objective To establish an HPLC method for the determination of Tectoridin and Tectorigenin in Flos Puerariae lobata. Method The separation was performed on Agilent -C18 column(4.6 mm×250 mm,5 μm),using a mobile phase with methanol-acetonitrile-water(2∶1∶2). Flow rate was 1.0ml/min,the detection wavelength was set at 264 nm. Column temperature was ambient temperature. Result The linear range of tectoridin was 2.0 ~120.0 μg/ml,r=0.999 8.The average recovery was 99.7%,RSD was 1.9%;The linear range of tectorigenin was 0.8 ~80.0 μg/ml,r=0.998 6.The average recovery was 99.4%,RSD was 1.7%. Conclusion The method was simple ,accurate,reliable with a good repeatability,which could be used to determinate of tectoridin and tectorigenin in Flos Puerariae lobata.
2012, 30(3): 229-231.
doi: 10.3969/j.issn.1006-0111.2012.03.021
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Objective To discuss the managed method of second order drug storeroom inventory under "zero inventory" model, and take advantages of "zero inventory" management, find the countermeasure, and ensure clinic drug use. Methods The model of "zero inventory"was introduced, and compared the inventory quantity, drug varieties and capital turnover rate before and after that zero inventory management was implemented. Results After zero inventory management was implemented, the varieties of drug in our hospital reduced to 200 from original more than 1 100, the drug inventory and the sum of money decreased obviously, the turnover rate rose substantially. Average capital turnover rate increased from 111% to 220.3%, and average capital turnover rate of outpatient pharmacy increased from 136.5% to 253.9%. Conclusion After implement of zero inventory management, the structure of inventory was optimized, the drug amount of inventory was decreased, the efficiency of medicines purchase was increased, the level of management was improved and the cost of hospital working was reduced.
Objective To discuss the managed method of second order drug storeroom inventory under "zero inventory" model, and take advantages of "zero inventory" management, find the countermeasure, and ensure clinic drug use. Methods The model of "zero inventory"was introduced, and compared the inventory quantity, drug varieties and capital turnover rate before and after that zero inventory management was implemented. Results After zero inventory management was implemented, the varieties of drug in our hospital reduced to 200 from original more than 1 100, the drug inventory and the sum of money decreased obviously, the turnover rate rose substantially. Average capital turnover rate increased from 111% to 220.3%, and average capital turnover rate of outpatient pharmacy increased from 136.5% to 253.9%. Conclusion After implement of zero inventory management, the structure of inventory was optimized, the drug amount of inventory was decreased, the efficiency of medicines purchase was increased, the level of management was improved and the cost of hospital working was reduced.
2012, 30(3): 232-234,238.
doi: 10.3969/j.issn.1006-0111.2012.03.022
Abstract:
Objective To discuss the situation and feature of the medical information spreading in China. Methods A quantitative questionnaire survey for 200 general individuals from Beijing and Wuhan, and 80 doctors in Beijing, Hubei, Jiangsu and Guangdong was done to discuss the channels and efficiency of medical information spreading. Conclusion People need to get medical information imminently. There are 5 main channels and methods, which had advantages and disadvantages. The spreading efficiency was limited.
Objective To discuss the situation and feature of the medical information spreading in China. Methods A quantitative questionnaire survey for 200 general individuals from Beijing and Wuhan, and 80 doctors in Beijing, Hubei, Jiangsu and Guangdong was done to discuss the channels and efficiency of medical information spreading. Conclusion People need to get medical information imminently. There are 5 main channels and methods, which had advantages and disadvantages. The spreading efficiency was limited.
2012, 30(3): 235-238.
doi: 10.3969/j.issn.1006-0111.2012.03.023
Abstract:
Objective To investigate the application of electronic prescriptions data in prescribing behavior research. Methods 2010 annual electronic prescription information diagnosis of peptic ulcer were collected in a district-level central hospital, SPSS(version18.0 ) was used to statistical analysis. Results Total amount of prescription prescribed by attending physicians were significantly different with residencies and chief physicians; Total amount and the total number of prescription without medical insurance were higher than those with medical insurance; there was a linear relationship among prescription total amount and medical insurance, patient age, the number constituent ratio of imported drugs, the number constituent ratio of own-expense drugs, the amount constituent ratio of own-expense drugs. Conclusion Attending physicians should be the focus group by outpatient consumption control interventions, medical insurance policies could not restrict at own-expense medicines prescription, electronic prescriptions data could be used in prescribing behavior research combined with treatment guidelines.
Objective To investigate the application of electronic prescriptions data in prescribing behavior research. Methods 2010 annual electronic prescription information diagnosis of peptic ulcer were collected in a district-level central hospital, SPSS(version18.0 ) was used to statistical analysis. Results Total amount of prescription prescribed by attending physicians were significantly different with residencies and chief physicians; Total amount and the total number of prescription without medical insurance were higher than those with medical insurance; there was a linear relationship among prescription total amount and medical insurance, patient age, the number constituent ratio of imported drugs, the number constituent ratio of own-expense drugs, the amount constituent ratio of own-expense drugs. Conclusion Attending physicians should be the focus group by outpatient consumption control interventions, medical insurance policies could not restrict at own-expense medicines prescription, electronic prescriptions data could be used in prescribing behavior research combined with treatment guidelines.
2012, 30(3): 239-240.
doi: 10.3969/j.issn.1006-0111.2012.03.001
Abstract:
Objective To improve the level of management of outpatient pharmacy in our hospital.Methods Power builder 6.5 software and data-mining technology were applied based on original hospital information system, the outpatient pharmacy information system was continuously upgraded.Results and Conclusions The working efficiency of outpatient pharmacy was greatly improved by the information system. The patient's waiting time was shortened,and the incidence of error was greatly reduced.
Objective To improve the level of management of outpatient pharmacy in our hospital.Methods Power builder 6.5 software and data-mining technology were applied based on original hospital information system, the outpatient pharmacy information system was continuously upgraded.Results and Conclusions The working efficiency of outpatient pharmacy was greatly improved by the information system. The patient's waiting time was shortened,and the incidence of error was greatly reduced.
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