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Volume 30 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(5): 357-360

HE Ai-ming, WANG Yi-hui, LIN Shi-ming. The effect of Fructus Mume water extract on experimental ulcerative colitis in mice[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 357-360. doi: 10.3969/j.issn.1006-0111.2012.05.011
Citation: HE Ai-ming, WANG Yi-hui, LIN Shi-ming. The effect of Fructus Mume water extract on experimental ulcerative colitis in mice[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 357-360. doi: 10.3969/j.issn.1006-0111.2012.05.011
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The effect of Fructus Mume water extract on experimental ulcerative colitis in mice

doi: 10.3969/j.issn.1006-0111.2012.05.011
  • 1.

    Department of biology and chemistry, Fuqing branch of Fujian normal university, Fuqing 350300, China

  • 2.

    Department of pharmacology, Fuqing health school of Fujian Province, Fuqing 350300, China

  • Received Date: 2012-01-17
  • Rev Recd Date: 2012-03-20
  • Objective To study the effect of Fructus Mume(FM) on superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in ulcerative colitis in mouse. Methods The mouse model of ulcerative colitis was set up by giving 3% dextran sulfate sodium(DSS) solution to the mouse as free drinking water, the normal group, model group were given 0.33 ml 0.9%Nacl, while FM high, middle and low dose groups were given the designed dosage by intragastric administration once a day, and last for 10 days. The occult blood test, observation of stool and the disease activity score (DAI) were observed. The colonic tissue morphology score was observed by visual inspection combined with microscope;SOD activity and MDA content of the lesions colon tissue were determined. Results The groups of FM high and middle dose had loose stools but no visible blood. DAI of all groups had decreased. There was significant difference (P< 0.01) in DAI between middle and high dose groups with model group. In the colonic mucosal pathological changes, FM high dose group had no severe mucosal erosion, ulcer, mucosal hyperemia and edema degree of light. In the determination of the activity of SOD value, FM high dose group, compared with the model group was significant difference (P< 0.01), higher than that in the model group. FM middle dose group compared with the normal group was significant difference (P< 0.05). There were no significant difference between FM high dose group and normal group. The measured MDA content, FM high dose group compared with the model group was significant difference (P< 0.01), which was lower than that in the model group. Conclusions Free radicals were closely related to UC colonic tissue damage, which participated in UC pathological process. FM had obvious therapeutic effect on UC, and it might play a therapeutic role by enhancing the lesion tissue SOD activity and lower MDA content in UC.
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    [2] 吴邱保.加味乌梅丸与柳氮磺毗啶治疗慢性溃疡性结肠炎的疗效比较[J].广东医学院学报,2006,24(5):487.
    [3] 郭洪波,罗玉梅,王静波.乌梅汤加减治疗溃疡性结肠炎44例[J].新中医,2007,39(1):44.
    [4] 董少群,李耀清.乌梅丸加减治疗慢性非特异性溃疡性结肠炎64例[J].河南医药信息,2002,10(17):45.
    [5] 王璐,张红宇,王莉.乌梅及其炮制品大鼠长期毒性研究[J].云南中医中药杂志,2010,31(10):67.
    [6] 易先国,李卫,吴海港,等.香连滴丸对溃疡性结肠炎模型小鼠疗效试验[J].中国兽医杂志,2010,46(11):28.
    [7] 张涛,施斌,陈建永,等.溃疡性结肠炎大鼠结肠黏膜CINC-1及其受体CXCR2的表达及意义[J].世界华人消化杂志,2009,17(1):78.
    [8] 刘颖,王莹.甘草酸二铵抗大鼠溃疡性结肠炎作用及抗炎机制研究[J].中国新药杂志,2007,16(14):2027.
    [9] 刘诗权,于皆平,冉宗学.银杏叶萃取物抗肝纤维化作用的实验研究[J].中华临床医药,2002,3(11):1.
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The effect of Fructus Mume water extract on experimental ulcerative colitis in mice

doi: 10.3969/j.issn.1006-0111.2012.05.011
  • 1. Department of biology and chemistry, Fuqing branch of Fujian normal university, Fuqing 350300, China
  • 2. Department of pharmacology, Fuqing health school of Fujian Province, Fuqing 350300, China
  • Received Date: 2012-01-17
  • Rev Recd Date: 2012-03-20

Abstract: Objective To study the effect of Fructus Mume(FM) on superoxide dismutase(SOD) activity and malondialdehyde(MDA) content in ulcerative colitis in mouse. Methods The mouse model of ulcerative colitis was set up by giving 3% dextran sulfate sodium(DSS) solution to the mouse as free drinking water, the normal group, model group were given 0.33 ml 0.9%Nacl, while FM high, middle and low dose groups were given the designed dosage by intragastric administration once a day, and last for 10 days. The occult blood test, observation of stool and the disease activity score (DAI) were observed. The colonic tissue morphology score was observed by visual inspection combined with microscope;SOD activity and MDA content of the lesions colon tissue were determined. Results The groups of FM high and middle dose had loose stools but no visible blood. DAI of all groups had decreased. There was significant difference (P< 0.01) in DAI between middle and high dose groups with model group. In the colonic mucosal pathological changes, FM high dose group had no severe mucosal erosion, ulcer, mucosal hyperemia and edema degree of light. In the determination of the activity of SOD value, FM high dose group, compared with the model group was significant difference (P< 0.01), higher than that in the model group. FM middle dose group compared with the normal group was significant difference (P< 0.05). There were no significant difference between FM high dose group and normal group. The measured MDA content, FM high dose group compared with the model group was significant difference (P< 0.01), which was lower than that in the model group. Conclusions Free radicals were closely related to UC colonic tissue damage, which participated in UC pathological process. FM had obvious therapeutic effect on UC, and it might play a therapeutic role by enhancing the lesion tissue SOD activity and lower MDA content in UC.

HE Ai-ming, WANG Yi-hui, LIN Shi-ming. The effect of Fructus Mume water extract on experimental ulcerative colitis in mice[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 357-360. doi: 10.3969/j.issn.1006-0111.2012.05.011
Citation: HE Ai-ming, WANG Yi-hui, LIN Shi-ming. The effect of Fructus Mume water extract on experimental ulcerative colitis in mice[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 357-360. doi: 10.3969/j.issn.1006-0111.2012.05.011
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